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Glucagen (Glucagon) - Summary

 


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GLUCAGEN SUMMARY

GlucaGen®  (glucagon [rDNA origin] for injection)

GlucaGen® [glucagon (rDNA origin) for injection] manufactured by Novo Nordisk A/S is produced by expression of recombinant DNA in a saccharomyces cerevisiae vector with subsequent purification.

For the treatment of hypoglycemia: GlucaGen® is used to treat severe hypoglycemic (low blood sugar) reactions which may occur in patients with diabetes treated with insulin.

Because GlucaGen® depletes glycogen stores, the patient should be given supplemental carbohydrates as soon as he/she awakens and is able to swallow, especially children or adolescents.

Medical evaluation is recommended for all patients who experience severe hypoglycemia.

For use as a diagnostic aid: GlucaGen® is indicated for use during radiologic examinations to temporarily inhibit movement of the gastrointestinal tract. Glucagon is as effective for this examination as are the anticholinergic drugs. However, the addition of the anticholinergic agent may result in increased side effects. Because GlucaGen depletes glycogen stores, the patient should be given oral carbohydrates as soon as the procedure is completed.


See all Glucagen indications & dosage >>

GLUCAGEN NEWS HIGHLIGHTS

Published Studies Related to Glucagen (Glucagon)

Miglitol suppresses the postprandial increase in interleukin 6 and enhances active glucagon-like peptide 1 secretion in viscerally obese subjects. [2008.09]

Glucagon-like peptide-1 inhibits blood-brain glucose transfer in humans. [2008.02]

Exogenous glucagon effects on health and reproductive performance of lactating dairy cows with mild fatty liver. [2007.12]

Glucagon-like peptide-1 (7-36) amide response to low versus high glycaemic index preloads in overweight subjects with and without type II diabetes mellitus. [2007.12]

Glucagon-like peptide 1 (GLP-1) suppresses ghrelin levels in humans via increased insulin secretion. [2007.10.04]

more >>

Clinical Trials Related to Glucagen (Glucagon)

A Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamic Activity of Very Low Dose-Glucagon in Subjects With Type 1 Diabetes Mellitus [Completed]

Influence of Glucagon Inhibition in Relation to the Anti-Diabetic Effect of Glucagon-Like Peptide-1 (GLP-1) in Patients With Type 2 Diabetes Mellitus [Active, not recruiting]

GIP, GLP-1 and GLP-2 in Type 2 Diabetic Hyperglucagonemia [Recruiting]

Glucagon in the Treatment of Hypoglycemia in Newborn Infants of Diabetic Mothers [Recruiting]

The Role of Amylin and Glucagon in T1DM [Completed]

more >>

Page last updated: 2008-11-03

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