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Geocillin (Carbenicillin Indanyl Sodium) - Summary

 

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GEOCILLIN SUMMARY

GEOCILLIN®
carbenicillin indanyl sodium
TABLETS
For Oral Use

Geocillin, a semisynthetic penicillin, is the sodium salt of the indanyl ester of Geopen® (carbenicillin disodium).

Geocillin (carbenicillin indanyl sodium) is indicated in the treatment of acute and chronic infections of the upper and lower urinary tract and in asymptomatic bacteriuria due to susceptible strains of the following organisms:

   Escherichia coli

   Proteus mirabilis

   Morganella morganii (formerly Proteus morganii)

   Providencia rettgeri (formerly Proteus rettgeri)

   Proteus vulgaris

  Pseudomonas

  Enterobacter

  Enterococci

Geocillin is also indicated in the treatment of prostatitis due to susceptible strains of the following organisms:

  Escherichia coli

    Enterococcus (S. faecalis)

   Proteus mirabilis

   Enterobacter sp.

WHEN HIGH AND RAPID BLOOD AND URINE LEVELS OF ANTIBIOTIC ARE INDICATED, THERAPY WITH GEOPEN (CARBENICILLIN DISODIUM) SHOULD BE INITIATED BY PARENTERAL ADMINISTRATION FOLLOWED, AT THE PHYSICIAN'S DISCRETION, BY ORAL THERAPY.

NOTE: Susceptibility testing should be performed prior to and during the course of therapy to detect the possible emergence of resistant organisms which may develop.

To reduce the development of drug-resistant bacteria and maintain effectiveness of Geocillin and other antibacterial drugs, Geocillin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

GEOCILLIN NEWS HIGHLIGHTS

Published Studies Related to Geocillin (Carbenicillin)

Randomized trial comparing oral ciprofloxacin plus penicillin V with amikacin plus carbenicillin or ceftazidime for empirical treatment of febrile neutropenic cancer patients. [1995.10]

Ceftazidime with or without vancomycin vs. cephalothin, carbenicillin and gentamicin as the initial therapy of the febrile neutropenic pediatric cancer patient. [1988.03]

Inhaled ceftazidime compared with gentamicin and carbenicillin in older patients with cystic fibrosis infected with Pseudomonas aeruginosa. [1987.07]

Development and validation of an LC method for the quantitation of carbenicillin in human serum. [1994.06]

Adverse reactions to prolonged treatment with high doses of carbenicillin and ureidopenicillins. [1991.01]

more>>

Clinical Trials Related to Geocillin (Carbenicillin)

Zithromax EV in Community-Acquired Pneumonia (CAP) [Completed]

Study Comparing the Safety and Efficacy of Tigecycline With Ampicillin-Sulbactam or Amoxicillin-Clavulanate to Treat Skin Infections [Recruiting]

Prospective Comparison of Ampicillin / Amoxicillin Versus Ceftriaxone for the Treatment of Salmonella Infections in AIDS Patients [Completed]

The Efficacy of Prophylactic Antibiotic Administration During Breast Cancer Surgery in Overweight Patients. [Recruiting]

Management of Early Onset Neonatal Septicaemia: Selection of Optimal Antibacterial Regimen for Empiric Treatment [Completed]

more>>

Page last updated: 2007-02-12

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