GENTAK® Gentamicin sulfate is a water soluble antibiotic of the aminoglycoside group.
Gentamicin sulfate ophthalmic ointment is a sterile ointment for ophthalmic use. Each gram contains gentamicin sulfate equivalent to 3 mg gentamicin in a base of white petrolatum and mineral oil, with methylparaben and propylparaben as preservatives.
Gentamicin is obtained from cultures of Micromonospora purpurea. It is a mixture of the sulfate salts of gentamicin C1, C2, and C1A. All three components appear to have similar antimicrobial activities. Gentamicin sulfate occurs as a white to buff powder and is soluble in water and insoluble in alcohol.
Gentamicin sulfate ophthalmic ointment is indicated in the topical treatment of ocular bacterial infections including conjunctivitis, keratitis, keratoconjunctivitis, corneal ulcers, blepharitis, blepharonconjunctivitis, acute meibomianitis, and dacryocystitis, caused by susceptible strains of the following microorganisms:
Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus pneumoniae, Enterobacter aerogenes, Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Neisseria gonorrhoeae, Pseudomonas aeruginosa, and Serratia marcescens.
Published Studies Related to Gentak (Gentamicin Ophthalmic)
Effects of intracameral triamcinolone and gentamicin injections following cataract surgery. [2011.07]
CONCLUSION: Intracameral injections of triamcinolone acetonide and gentamicin appear to be a promising treatment option for the control of post-operative inflammation following cataract surgery.
Use of povidone-iodine drop instead of sub-conjunctival injection of dexamethasone and gentamicin combination at the end of phacoemulsification cataract surgery. [2010.04]
To evaluate the use of 5% povidone-iodine drop with subconjunctival injection of dexamethasone and gentamicin combination at the completion of phacoemulsification cataract surgery. This prospective randomized study was conducted at the department of Ophthalmology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh during the period of July, 2005 to June 2006...
Side effects of postoperative administration of methylprednisolone and gentamicin into the posterior sub-Tenon's space. [2007.05]
PURPOSE: To assess the incidence of postoperative emetic side effects after the administration of methylprednisolone and gentamicin into the posterior sub-Tenon's space at the end of routine cataract surgery. SETTING: St. Luke's Hospital, Gwardamangia, Malta... CONCLUSIONS: The administration of methylprednisolone and gentamicin in the posterior sub-Tenon's space was related to a high incidence of side effects including nausea, vomiting, and headache. All adverse effects were self-limiting.
Intravitreal gentamicin-induced macular infarction: SD-OCT features. [2011.08.04]
A 75-year-old woman developed acute-onset endophthalmitis following phacoemulsification in the left eye. She was treated with intravitreal injections of vancomycin, ceftazidime, and gentamicin... This case demonstrates SD-OCT features in macular infarction following intravitreal gentamicin, specifically changes involving the inner retina with a relatively intact outer retina.
Severe ocular reactions after neonatal ocular prophylaxis with gentamicin ophthalmic ointment. [2011.02]
In this study, we report 4 infants who developed severe ocular reactions after neonatal ocular prophylaxis with gentamicin ophthalmic ointment during a period of erythromycin ophthalmic ointment shortage.
Clinical Trials Related to Gentak (Gentamicin Ophthalmic)
Gentamicin Treatment Prior to Schwannoma Surgery - Residual Function [Recruiting]
The purpose of the study is to determine whether vestibular and postural compensation
following schwannoma surgery is improved by ablating remaining vestibular function prior to
surgery, through gentamicin injections in the middle ear.
Local Gentamicin Application to Reduce Postoperative Infection Rate [Completed]
The majority of elderly patients with a displaced fracture of the proximal femur are now
treated with a hemiarthroplasty. Prosthetic joint infection is a devastating complication,
and the infection rate is high in this group of elderly patients. Local application of
gentamicin produces high antibiotic concentrations in the wound. The aim of this study is to
determine whether locally administered collagen-gentamicin in the joint perioperatively in
addition to routine IV prophylaxis with beta-lactam antibiotics can reduce the early
postoperative infection rate (< 4 weeks postoperative)after hemiarthroplasty in proximal
Gentamicin Bladder Instillation Trial [Recruiting]
Recurrent UTIs are common among patients on IC. These create significant patient morbidity
and healthcare burden. In desperation, many physicians prescribe prophylactic oral or
intravesical antibiotics. This practice is common among our Gillette clinic patients.
However, the benefit is unclear and the risks are not insignificant. As such, practice
variation is significant. In order to better define the evidence for or against gentamicin
bladder irrigation and thus inform clinical practice both locally at our Gillette urology
clinic and for practitioners at large we will pursue the following specific aims:
1. Compare rates of symptomatic urinary tract infection and asymptomatic bacteriuria among
a population of Gillette patients on IC with and without gentamicin bladder
2. Compare antibiotic resistance rates among a population of Gillette patients on IC with
and without gentamicin bladder instillation.
Pharmacokinetic (PK) and Pharmacodynamic (PD) Modeling of Ampicillin and Gentamicin in Peripartum Patients [Not yet recruiting]
This study proposes to compare the metabolism of Ampicillin and Gentamicin by pregnant women
to that of non-pregnant women; the placental transfer over time; and the subsequent
metabolism of the transferred drug(s) in the neonate.
Topical Gentamicin Cream Versus Alternating Gentamicin and Mupirocin Cream in Peritoneal Dialysis [Not yet recruiting]
Catheter-related infection, namely exit site infection and peritonitis, is the commonest
complication of peritoneal dialysis. This complication causes significant morbidity and
mortality in patients requiring peritoneal dialysis. Topical application of mupirocin 2%
cream was first proven to be effective in reduction of staphylococcus-related catheter
infection in 1990s. Subsequent randomized trial published in 2005 showed that gentamicin
cream was superior to mupirocin 2% cream in reducing both Gram's positive and Gram's
negative related catheter infection. However, a retrospective report published in 2007 puts
the use of prophylactic antibiotic cream into a question. It reported an emergency of
non-tuberculous mycobacterial infection in a dialysis center in Hong Kong after practising
prophylactic application of gentamicin cream at the catheter exit site. The following
prospective, randomized and open-label study aims to find out an optimal regimen of topical
antibiotic prophylaxis in patients requiring peritoneal dialysis.
Page last updated: 2011-12-09