Myelosuppression, paresthesias, and severe rash were the principal toxicities seen when a single dose as high as 5700 mg/m2 was administered by intravenous infusion over 30 minutes every 2 weeks to several patients in a dose-escalation study.
CONTRAINDICATIONS
Gemzar is contraindicated in patients with a known hypersensitivity to gemcitabine.