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Ganirelix (Ganirelix Acetate) - Summary



Ganirelix Acetate Injection is a synthetic decapeptide with high antagonistic activity against naturally occurring gonadotropin-releasing hormone (GnRH).

Ganirelix Acetate Injection is indicated for the inhibition of premature LH surges in women undergoing controlled ovarian hyperstimulation.

See all Ganirelix indications & dosage >>


Media Articles Related to Ganirelix

Study suggests same-sex couples face more obstacles to infertility treatment
Source: Fertility News From Medical News Today [2015.08.24]
Same-sex couples encounter more obstacles to treatment for infertility than opposite-sex couples, suggests a new study that was presented at the 110th Annual Meeting of the American Sociological...

Study of cholesterol in cells offers clues on infertility and early puberty
Source: Cholesterol News From Medical News Today [2015.06.18]
Cells use cholesterol to make the steroid hormones that trigger puberty and support pregnancy. Now, a new study of this may help find causes of infertility and early puberty.

Cycling and risk for erectile dysfunction, infertility, prostate cancer
Source: Erectile Dysfunction / Premature Ejaculation News From Medical News Today [2014.07.08]
Cycling is a popular activity that offers clear health benefits, but there is an ongoing controversy about whether men who ride have a higher risk of urogenital disorders such as erectile...

Infertility Pictures Slideshow: Which Treatment Is Right for You?
Source: MedicineNet Turner Syndrome Specialty [2014.05.01]
Title: Infertility Pictures Slideshow: Which Treatment Is Right for You?
Category: Slideshows
Created: 12/10/2010 5:53:00 PM
Last Editorial Review: 5/1/2014 12:00:00 AM

Source: MedicineNet Celiac Disease Specialty [2013.07.15]
Title: Infertility
Category: Diseases and Conditions
Created: 11/17/2004 12:00:00 AM
Last Editorial Review: 7/15/2013 12:00:00 AM

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Published Studies Related to Ganirelix

A randomized trial of microdose leuprolide acetate protocol versus luteal phase ganirelix protocol in predicted poor responders. [2011.06.30]
We performed a randomized trial to compare IVF outcomes in 54 poor responder patients undergoing a microdose leuprolide acetate (LA) protocol or a GnRH antagonist protocol incorporating a luteal phase E(2) patch and GnRH antagonist in the preceding menstrual cycle.

The effect of cetrorelix vs. ganirelix on pregnancy outcome using minimal gonadotropin stimulation in women with elevated day 3 serum follicle stimulating hormone levels. [2009]
CONCLUSIONS: The trend for lower pregnancy rates with ganirelix vs. cetrorelix seen in women with diminished egg reserve is consistent with the findings of a study performed in women with normal egg reserve using a normal gonadotropin stimulation regimen. It is not clear if the adverse effect is on the endometrium or the embryo.

Treatment with the GnRH antagonist ganirelix prevents premature LH rises and luteinization in stimulated intrauterine insemination: results of a double-blind, placebo-controlled, multicentre trial. [2006.03]
BACKGROUND: This study was designed to assess whether the use of ganirelix in women undergoing stimulated IUI could prevent the occurrence of premature LH rises and luteinization (LH+progesterone rises)... CONCLUSIONS: Treatment with ganirelix effectively prevents premature LH rises, luteinization in subjects undergoing stimulated IUI. Low-dose rFSH regimen combined with a GnRH antagonist may be an alternative treatment option for subjects with previous proven luteinization or in subjects who would otherwise require insemination when staff are not working.

LH suppression following different low doses of the GnRH antagonist ganirelix in polycystic ovary syndrome. [2005.12]
Elevated LH concentration is a common feature in polycystic ovary syndrome (PCOS). This study was designed to establish whether elevated LH levels in PCOS might be suppressed to normal range values by the administration of different low doses of GnRH antagonist, which subsequently might reverse the anovulatory status of these patients...

Prospective, randomized trial comparing cetrorelix acetate and ganirelix acetate in a programmed, flexible protocol for premature luteinizing hormone surge prevention in assisted reproductive technologies. [2005.07]
OBJECTIVE: To compare the safety and efficacy of single-dose cetrorelix acetate (3 mg) and daily ganirelix acetate (0.25 mg) in the inhibition of premature LH surge in women undergoing cycle-programmed ovarian stimulation before Assisted Reproductive Technology (ART).CONCLUSION(S): Cetrorelix and ganirelix effectively prevented LH surges in oral contraceptive (OC) pill-programmed, flexible protocols, with similar safety profiles and PRs; however, cetrorelix required significantly fewer injections, increasing patient convenience.

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Page last updated: 2015-08-24

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