Zinc acetate as the dihydrate is a salt of zinc used to inhibit the absorption of copper in patients with Wilson's disease.
Zinc acetate therapy is indicated for maintenance treatment of patients with Wilsons disease who have been initially treated with a chelating agent (See PRECAUTIONS: Monitoring Patients).
Published Studies Related to Galzin (Zinc Acetate)
The effect of zinc acetate and magnolia bark extract added to chewing gum on
volatile sulfur-containing compounds in the oral cavity. 
sugar-free chewing gum for two hours... CONCLUSION: Chewing gum containing zinc acetate and magnoliabark extract can
A randomized controlled trial of oral zinc in acute pneumonia in children aged between 2 months to 5 years. [2011.09]
OBJECTIVE: To evaluate the effectiveness and safety of zinc supplementation as adjuvant in treatment of pneumonia... CONCLUSIONS: Though well tolerated; the addition of zinc does not improve symptom duration or cure rate in acute bacterial pneumonia in under-five children.
Zinc lozenges as cure for the common cold--a review and hypothesis. 
A 7-day reduction in duration of common colds was shown by Eby et al.Due to inadequate lozenge iZn very few
of more than 40 different brands of zinc lozenges on the US market are expected
to have any effect on the duration or severity of common colds.
Duration and severity of symptoms and levels of plasma interleukin-1 receptor antagonist, soluble tumor necrosis factor receptor, and adhesion molecules in patients with common cold treated with zinc acetate. [2008.03.15]
BACKGROUND: Zinc lozenges have been used for treatment of the common cold; however, the results remain controversial... CONCLUSION: Administration of zinc lozenges was associated with reduced duration and severity of cold symptoms. We related the improvement in cold symptoms to the antioxidant and anti-inflammatory properties of zinc.
Duration and Severity of Symptoms and Levels of Plasma Interleukin-1 Receptor Antagonist, Soluble Tumor Necrosis Factor Receptor, and Adhesion Molecules in Patients with Common Cold Treated with Zinc Acetate. [2008.02.15]
Background. @nbsp; Zinc lozenges have been used for treatment of the common cold; however, the results remain controversial...
Clinical Trials Related to Galzin (Zinc Acetate)
Efficacy and Safety Study of Zinc Acetate to Treat Wilson's Disease in Japan. [Completed]
The purpose of this study is to determine whether Zinc Acetate is effective and safe in the
treatment of Wilson's disease among Japanese.
Efficacy and Safety, Long-term Study of Zinc Acetate to Treat Wilson's Disease in Japan. [Completed]
The purpose of this long-term study is to determine whether Zinc Acetate is effective and
safe in the treatment of Wilson's disease among Japanese.
The Impact of Zinc Supplementation on Left Ventricular Function in Nonischemic Cardiomyopathy [Completed]
Heart failure affects over 5. 3 million Americans and, while other cardiovascular diseases
have enjoyed a reduction in mortality rates over the last decade, the mortality from heart
failure continues to rise. Thus, identifying novel therapies that can reduce heart
failure development and/or progression are warranted. Unifying to most cardiomyopathic
processes is an impaired handling of reactive oxygen species (ROS)[2-4]. Reactive oxygen
species are generated as byproducts of inflammation and oxidative stress that occur in the
setting of normal myocardial aerobic metabolism. Metallothionein, glutathione reductase,
and superoxide dismutase are major antioxidants in the myocardium that help combat oxidative
stress and prevent myocardial damage. In certain clinical settings, including cardiac
ischemia, diabetes, and heavy metal excess (copper, iron), myocardial oxidative stress
levels are greatly increased. When pro-oxidant levels exceed myocardial antioxidant
capabilities, ROS-induced membrane, protein, and DNA inactivation can lead to the
development of cardiac dysfunction.
One means of preventing the development or progression of cardiomyopathy is to reduce
oxidative stress through up-regulation of intramyocardial antioxidants. Murine studies of
cardiomyopathy have shown that oral administration of zinc acetate may succeed as an
indirect myocardial anti-oxidant because zinc sufficiently up-regulates the intramyocardial
production of superoxide dismutase (a zinc-dependant anti-oxidant enzyme) and
metallothionein (a "super antioxidant") [5-8]. Zinc also directly reduces prooxidant Cu
levels by reducing gastrointestinal zinc absorption. However, to date, no studies have
examined the impact of zinc acetate supplementation in subjects with cardiomyopathy and
systolic failure on antioxidant capacity and remodeling.
The hypothesis of this pilot study is that administration of oral zinc acetate to humans
with cardiomyopathy will lead to an up-regulation of myocardial anti-oxidant
capabilities,leading to a favorable reduction in oxidative stress. This study will provide
preliminary data to support a randomized, placebo-controlled trial of zinc therapy in heart
failure as a means of improving or preventing the progression of systolic dysfunction in
subjects with mild-moderate heart failure.
Zinc Homeostasis and Kinetics in Children With Cystic Fibrosis (CF) [Completed]
Zinc deficiency has occasionally been reported in CF, but the need for additional zinc is
unclear. We will examine the effect of additional zinc supplements on zinc absorption, zinc
excretion, zinc balance and zinc kinetics in children with CF. Twelve children with CF will
receive additional zinc, and twelve will not. We will also compare the children with CF to
12 healthy children without CF. We hypothesize that children with CF will have poor zinc
absorption and high zinc excretion, leading to poor zinc balance and abnormal zinc kinetics.
We hypothesize that those children with CF who are given zinc supplements will have higher
zinc balance and more normal zinc kinetics than those without supplementation, and that zinc
balance and zinc kinetics will be similar to healthy children.
Safety, Pharmacokinetics and Acceptability of PC-1005 for Vaginal Use [Active, not recruiting]
This Phase 1 clinical trial will evaluate MIV-150, a third generation non-nucleoside reverse
transcriptase inhibitor, co-formulated with a potentially potent agent, zinc acetate for the
prevention of HIV infection in women. This is the first in-human of PC-1005 (MIV-150/zinc
acetate in a carrageenan gel), the first study in which females will be exposed to MIV-150,
the first time MIV-150 will be administered topically, and the first time MIV-150 will be
PATIENT REVIEWS / RATINGS / COMMENTS
Based on a total of 2 ratings/reviews, Galzin has an overall score of 5. The effectiveness score is 6 and the side effect score is 7. The scores are on ten point scale: 10 - best, 1 - worst.
Galzin review by care giver of 6 year old male patient
|Overall rating:|| || |
|Effectiveness:|| || Moderately Effective|
|Side effects:|| || No Side Effects|
|Condition / reason:|| || Mucus in stool|
|Dosage & duration:|| || 5 ml (dosage frequency: 12 months) for the period of 6 days|
|Other conditions:|| || fever|
|Other drugs taken:|| || Cepodem|
|Benefits:|| || recoverd from loose motions. nothing more to add. thanks nothing more to add. thanks nothing more to add. thanks nothing more to add. thanks nothing more to add. thanks nothing more to add. thanks|
|Side effects:|| || none. nothing more to add. thanks nothing more to add. thanks nothing more to add. thanks nothing more to add. thanks nothing more to add. thanks nothing more to add. thanks|
|Comments:|| || Cepodem for 5 days. nothing more to add. thanks nothing more to add. thanks nothing more to add. thanks nothing more to add. thanks nothing more to add. thanks nothing more to add. thanks|
Galzin review by 43 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Moderately Effective|
|Side effects:|| || Severe Side Effects|
|Condition / reason:|| || Wilson Diseaes|
|Dosage & duration:|| || 150 mg taken 3 times for the period of 4 years|
|Other conditions:|| || Vomitting and nausea|
|Other drugs taken:|| || Gluzin|
|Benefits:|| || My daughter and I both suffer from Wilson Disease, we had taken Galzin for more than five years. But my daughter had especially bad stomach nausea and vomitting. We had made the switch over to Gluzin for a year now, and she no longer has any upset stomach.|
|Side effects:|| || Galzin has bad GI effects, upset stomach, vomitting, and LONG wait before and after meals.|
|Comments:|| || Took 50 MG three times a day.|
Page last updated: 2013-02-10