Gabitril (Tiagabine Hydrochloride) - Summary

GABITRIL SUMMARY

GABITRIL®
(tiagabine hydrochloride)
Tablets

GABITRIL (tiagabine HCl) is an antiepilepsy drug available as 2 mg, 4 mg, 12 mg, 16 mg tablets for oral administration. Its chemical name is (-)-(R)-1-[4,4-Bis(3-methyl-2-thienyl)-3-butenyl]nipecotic acid hydrochloride, its molecular formula is C₂₀H₂₅NO₂S₂HCl, and its molecular weight is 412.0. Tiagabine HCl is a white to off-white, odorless, crystalline powder. It is insoluble in heptane, sparingly soluble in water, and soluble in aqueous base.

GABITRIL (tiagabine hydrochloride) is indicated as adjunctive therapy in adults and children 12 years and older in the treatment of partial seizures.

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GABITRIL NEWS HIGHLIGHTS

Media Articles Related to Gabitril (Tiagabine)

Tiagabine May Be Useful Insomnia Treatment for Adults
Source: Medscape Pharmacotherapy Headlines [2004.06.11]

Clue to Cause of Epileptic Seizures Discovered
Source: MedicineNet Seizure Specialty [2008.11.25]

Researchers Find Relationship Between Brain Fluid And Adult Seizures
Source: Tropical Diseases News From Medical News Today [2008.11.06]

Common Sedative Linked To Deaths In Patients With Prolonged Seizures
Source: Epilepsy News From Medical News Today [2008.10.29]

UCB's Vimpat® Approved By U.S. FDA As Adjunctive Therapy For Partial Onset Seizures In Adults
Source: Epilepsy News From Medical News Today [2008.10.29]

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Published Studies Related to Gabitril (Tiagabine)

Tiagabine for social anxiety disorder. [2007.06]

Tiagabine does not attenuate alcohol-induced activation of the human reward system. [2007.05]

Comparison of the cognitive effects of tiagabine and carbamazepine as monotherapy in newly diagnosed adult patients with partial epilepsy: pooled analysis of two long-term, randomized, follow-up studies. [2006.07]

Long-term effects of tiagabine monotherapy on cognition and mood in adult patients with chronic partial epilepsy. [2006.06]

Tiagabine is associated with sustained attention during sleep restriction: evidence for the value of slow-wave sleep enhancement? [2006.04.01]

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Clinical Trials Related to Gabitril (Tiagabine)

Study To Evaluate The Effects Of Gabitril™ In Patients With Social Anxiety Disorder [Completed]

Effectiveness of Tiagabine for Cocaine Dependence in Methadone-Maintained Individuals - 1 [Completed]

Switching From an SSRI to Tiagabine(GABITRIL) in Order to Alleviate SSRI Induced Sexual Dysfunction [Completed]

Evaluate the Safety of GABITRIL in Adults With Generalized Anxiety Disorder [Completed]

Study to Evaluate the Safety and Efficacy of GABITRIL Treatment in Adults With Generalized Anxiety Disorder. [Completed]

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