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Furadantin (Nitrofurantoin) - Indications and Dosage



Furadantin is specifically indicated for the treatment of urinary tract infections when due to susceptible strains of Escherichia coli, enterococci, Staphylococcus aureus, and certain susceptible strains of Klebsiella and Enterobacter species.
Nitrofurantoin is not indicated for the treatment of pyelonephritis or perinephric abscesses.
Nitrofurantoins lack the broader tissue distribution of other therapeutic agents approved for urinary tract infections.  Consequently, many patients who are treated with Furadantin are predisposed to persistence or reappearance of bacteriuria.  Urine specimens for culture and susceptibility testing should be obtained before and after completion of therapy.  If persistence or reappearance of bacteriuria occurs after treatment with Furadantin, other therapeutic agents with broader tissue distribution should be selected.  In considering the use of Furadantin, lower eradication rates should be balanced against the increased potential for systemic toxicity and for the development of antimicrobial resistance when agents with broader tissue distribution are utilized. 


Furadantin should be given with food to improve drug absorption and, in some patients, tolerance.


50-100 mg four times a day -- the lower dosage level is recommended for uncomplicated urinary tract infections.

Pediatric Patients:

5-7 mg/kg of body weight per 24 hours, given in four divided doses (contraindicated under one month of age).
The following table is based on an average weight in each range receiving 5 to 6 mg/kg of body weight per 24 hours, given in four divided doses.  It can be used to calculate an average dose of Furadantin Oral Suspension (25 mg/5 mL) for pediatric patients (one 5-mL teaspoon of Furadantin Oral Suspension contains 25 mg of nitrofurantoin):

Body Weight
No. Teaspoonfuls
4 Times Daily
15 to 26
7 to 11
1/2 (2.5 mL)
27 to 46
12 to 21
1 (5 mL)
47 to 68
22 to 30
1 1/2 (7.5 mL)
69 to 91
31 to 41
2 (10 mL)

Therapy should be continued for one week or for at least 3 days after sterility of the urine is obtained.  Continued infection indicates the need for reevaluation.
For long-term suppressive therapy in adults, a reduction of dosage to 50-100 mg at bedtime may be adequate.  For long-term suppressive therapy in pediatric patients, doses as low as 1 mg/kg per 24 hours, given in a single dose or in two divided doses, may be adequate.  SEE WARNINGS SECTION REGARDING RISKS ASSOCIATED WITH LONG TERM THERAPY.


Furadantin Oral Suspension is available in:
NDC 59630-450-08  glass amber bottle of 230 mL
Avoid exposure to strong light which may darken the drug.  It is stable when stored between 20˚-25˚C (68˚-77˚F); excursions permitted to 15˚-30˚C (59˚-86˚F) [See USP Controlled Room Temperature].  Protect from freezing.  It should be dispensed in glass amber bottles.
Keep out of reach of children.
Rx only.

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