DOSAGE AND ADMINISTRATION:
Furadantin should be given with food to improve drug absorption and, in some patients, tolerance.
Adults:
50-100 mg four times a day -- the lower dosage level is recommended for uncomplicated urinary tract infections.
Pediatric Patients:
5-7 mg/kg of body weight per 24 hours, given in four divided doses (contraindicated under one month of age).
The following table is based on an average weight in each range receiving 5 to 6 mg/kg of body weight per 24 hours, given in four divided doses. It can be used to calculate an average dose of Furadantin Oral Suspension (25 mg/5 mL) for pediatric patients (one 5-mL teaspoon of Furadantin Oral Suspension contains 25 mg of nitrofurantoin):
Body Weight
| No. Teaspoonfuls
|
Pounds
| Kilograms
| 4 Times Daily
|
15 to 26
| 7 to 11
| 1/2 (2.5 mL)
|
27 to 46
| 12 to 21
| 1 (5 mL)
|
47 to 68
| 22 to 30
| 1 1/2 (7.5 mL)
|
69 to 91
| 31 to 41
| 2 (10 mL)
|
Therapy should be continued for one week or for at least 3 days after sterility of the urine is obtained. Continued infection indicates the need for reevaluation.
For long-term suppressive therapy in adults, a reduction of dosage to 50-100 mg at bedtime may be adequate. For long-term suppressive therapy in pediatric patients, doses as low as 1 mg/kg per 24 hours, given in a single dose or in two divided doses, may be adequate. SEE WARNINGS SECTION REGARDING RISKS ASSOCIATED WITH LONG TERM THERAPY.
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