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Fosrenol (Lanthanum Carbonate Hydrate) - Drug Interactions, Contraindications, Overdosage, etc


Rx only

Manufactured for Shire US Inc.

Wayne, PA 19087, USA


Revision Date: 9/2005

247 0107 002


Diagnostic Tests:

Abdominal x-rays of patients taking lanthanum carbonate may have a radio-opaque appearance typical of an imaging agent.


There is no experience with FOSRENOL® overdosage. Lanthanum carbonate was not acutely toxic in animals by the oral route. No deaths and no adverse effects occurred in mice, rats or dogs after single oral doses of 2000 mg/kg. In clinical trials, daily doses up to 4718 mg/day of lanthanum were well tolerated in healthy adults when administered with food, with the exception of GI symptoms. Given the topical activity of lanthanum in the gut, and the excretion in feces of the majority of the dose, supportive therapy is recommended for overdosage.


None known.

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