(ceftazidime for injection)
For Intravenous or Intramuscular Use
Ceftazidime is a semisynthetic, broad-spectrum, beta-lactam antibiotic for parenteral administration.
FORTAZ is indicated for the treatment of patients with infections caused by susceptible strains of the designated organisms in the following diseases:
- Lower Respiratory Tract Infections, including pneumonia, caused by
spp.; Haemophilus influenzae,
including ampicillin-resistant strains; Klebsiella
spp.; Proteus mirabilis; Escherichia coli; Serratia
spp.; Streptococcus pneumoniae;
- Skin and Skin Structure Infections caused by
Pseudomonas aeruginosa; Klebsiella
spp.; Escherichia coli; Proteus
spp.; Staphylococcus aureus
(methicillin-susceptible strains); and
(group A beta-hemolytic streptococci).
- Urinary Tract Infections, both complicated and uncomplicated, caused by
Pseudomonas aeruginosa; Enterobacter
- Bacterial Septicemia caused by
Pseudomonas aeruginosa, Klebsiella
spp., Haemophilus influenzae, Escherichia coli, Serratia
spp., Streptococcus pneumoniae,
- Bone and Joint Infections caused by
Pseudomonas aeruginosa, Klebsiella
- Gynecologic Infections, including endometritis, pelvic cellulitis, and other infections of the female genital tract caused by
- Intra-abdominal Infections, including peritonitis caused by
Escherichia coli, Klebsiella
(methicillin-susceptible strains) and polymicrobial infections caused by aerobic and anaerobic organisms and
spp. (many strains of
- Central Nervous System Infections, including meningitis, caused by
Neisseria meningitidis. Ceftazidime has also been used successfully in a limited number of cases of meningitis due to
FORTAZ may be used alone in cases of confirmed or suspected sepsis. Ceftazidime has been used successfully in clinical trials as empiric therapy in cases where various concomitant therapies with other antibiotics have been used.
FORTAZ may also be used concomitantly with other antibiotics, such as aminoglycosides, vancomycin, and clindamycin; in severe and life-threatening infections; and in the immunocompromised patient. When such concomitant treatment is appropriate, prescribing information in the labeling for the other antibiotics should be followed. The dose depends on the severity of the infection and the patient's condition.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of FORTAZ and other antibacterial drugs, FORTAZ should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Media Articles Related to Fortaz (Ceftazidime)
FDA approves new antibacterial drug Avycaz
Source: Urology / Nephrology News From Medical News Today [2015.02.27]
The U.S. Food and Drug Administration has approved Avycaz (ceftazidime-avibactam), a new antibacterial drug product, to treat adults with complicated intra-abdominal infections (cIAI), in...
FDA Approves Antibiotic Combo
Source: MedPageToday.com - medical news plus CME for physicians [2015.02.27]
(MedPage Today) -- Ceftazidime-avibactam approved for complicated abdominal and urinary tract infections.
Published Studies Related to Fortaz (Ceftazidime)
Nebulized ceftazidime and amikacin in ventilator-associated pneumonia caused by Pseudomonas aeruginosa. [2011.07.01]
RATIONALE: In experimental pneumonia, nebulization of antibiotics provides high lung tissue concentrations and rapid bacterial killing. OBJECTIVES: To assess the efficacy and safety of nebulized ceftazidime and amikacin in ventilator-associated pneumonia caused by Pseudomonas aeruginosa... CONCLUSIONS: Nebulization and intravenous infusion of ceftazidime and amikacin provide similar efficiency for treating ventilator-associated pneumonia caused by Pseudomonas aeruginosa. Nebulization is efficient against intermediate strains and may prevent per-treatment acquisition of antibiotic resistance.
Continuous vs thrice-daily ceftazidime for elective intravenous antipseudomonal therapy in cystic fibrosis. [2009.10]
BACKGROUND/AIM: We hypothesized that a continuous 24-h infusion of 100 mg/kg per day ceftazidime (treatment C) would result in equivalent or even superior anti-infectious efficacy in chronic Pseudomonus aeruginosa (PA) infection in patients with cystic fibrosis (CF) in comparison to the usual application of 200 mg/kg per day ceftazidime in three doses (treatment T)... CONCLUSION: We conclude that continuous or thrice-daily dosing of intravenous ceftazidime, both combined with once-daily tobramycin, are equally effective application regimens for elective antipseudomonal therapy in clinically stable patients with CF.
Piperacillin/tazobactam plus ceftazidime versus sulbactam/ampicillin plus aztreonam as empirical therapy for fever in severely neutropenic pediatric patients. [2009.04]
CONCLUSIONS: PIPC/TAZ+CAZ and SBT/ABPC+AZT are effective and safe for initial empirical treatment of febrile episodes in neutropenic pediatric patients. The clinical efficacy of SBT/ABPC+AZT is equivalent or superior to that of PIPC/TAZ+CAZ, the effect of which is already proven against febrile neutropenia. Therefore, SBT/ABPC+AZT may be a treatment of choice for febrile neutropenia in pediatric cancer patients.
A randomized, double-blind trial comparing ceftobiprole medocaril with vancomycin plus ceftazidime for the treatment of patients with complicated skin and skin-structure infections. [2008.03.01]
BACKGROUND: A randomized, double-blind, multicenter trial involving patients with a broad range of complicated skin and skin-structure infections due to either gram-positive or gram-negative bacteria was conducted to compare ceftobiprole monotherapy with treatment with vancomycin plus ceftazidime... CONCLUSIONS: Ceftobiprole monotherapy is as effective as vancomycin plus ceftazidime for treating patients with a broad range of complicated skin and skin-structure infections and infections due to gram-positive and gram-negative bacteria.
Piperacillin/tazobactam vs ceftazidime in the treatment of neutropenic fever in patients with acute leukemia or following autologous peripheral blood stem cell transplantation: a prospective randomized trial. [2006.02]
Piperacillin/tazobactam was compared with ceftazidime for the empirical treatment of febrile neutropenia in patients with acute leukemia or following autologous peripheral blood stem cell transplantation. Owing to inclusion criteria, it was possible for the same patient to be randomized several times.
Clinical Trials Related to Fortaz (Ceftazidime)
A Study to Assess the Levels of Two Antibiotics in the Blood When Given Together and Separately [Recruiting]
This is a randomised study divided into 2 parts. Part A investigates the effect of
prolonged dosing (ten days) with Avibactam and Ceftazidime when given together and how this
will effect how much Avibactam and Ceftazidime enters the blood. Part B investigates how
much Avibactam (NXL104) and Ceftazidime enter the blood when Avibactam and Ceftazidine are
given separately or together intravenously.
Study to Assess the Concentration of Avibactam and Ceftazidime in Epithelial Lining Fluid and Plasma [Recruiting]
Ceftazidime-Avibactam for the Treatment of Infections Due to Ceftazidime Resistant Pathogens [Not yet recruiting]
To Evaluate the Effects of Ceftazidime-Avibactam and Best Available Therapy in patients with
complicated urinary tract infections and complicated intra-abdominal infections.
Adverse Drug Reactions of Different Brands of Ceftazidime Injection [Active, not recruiting]
The purpose of this study is to understand whether generic ceftazidime causes different
adverse drug reaction incidence from the brand drug.
Daptomycin + Meropenem Versus Ceftazidime in the Treatment of Nosocomial Spontaneous Bacterial Peritonitis [Recruiting]
PATIENT REVIEWS / RATINGS / COMMENTS
Based on a total of 1 ratings/reviews, Fortaz has an overall score of 8. The effectiveness score is 10 and the side effect score is 6. The scores are on ten point scale: 10 - best, 1 - worst.
Fortaz review by 50 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Highly Effective|
|Side effects:|| || Moderate Side Effects|
|Condition / reason:|| || UTI|
|Dosage & duration:|| || 250 mg bid taken as directed for the period of 7days|
|Other conditions:|| || none|
|Other drugs taken:|| || none|
|Benefits:|| || got rid of the uti, however, it took longer than d-mannose a non-prescription otc natural sugar which also had no side-effects|
|Side effects:|| || vaginal yeast infection which required treatment|
|Comments:|| || This drug got rid of the infection, however, since that time I have discovered d-mannose from the health food store it works faster and does not have any side effects, is cheaper, no doctor visit required|
Page last updated: 2015-02-27