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Forane (Isoflurane) - Side Effects and Adverse Reactions



Adverse reactions encountered in the administration of FORANE (isoflurane, USP) are in general dose dependent extensions of pharmacophysiologic effects and include respiratory depression, hypotension and arrhythmias.

Shivering, nausea, vomiting and ileus have been observed in the postoperative period.

As with all other general anesthetics, transient elevations in white blood count have been observed even in the absence of surgical stress. See WARNINGS for information regarding malignant hyperthermia and elevated carboxyhemoglobin levels.

During marketing, there have been rare reports of mild, moderate and severe (some fatal) postoperative hepatic dysfunction and hepatitis.

FORANE (isoflurane, USP) has also been associated with perioperative hyperkalemia (see WARNINGS).

Post-Marketing Events

The following adverse events have been identified during post-approval use of FORANE (isoflurane, USP). Due to the spontaneous nature of these reports, the actual incidence and relationship of FORANE (isoflurane, USP) to these events cannot be established with certainty.

 Cardiac Disorders: Cardiac arrest

Hepatobiliary Disorders: Hepatic necrosis, Hepatic failure


Below is a sample of reports where side effects / adverse reactions may be related to Forane. The information is not vetted and should not be considered as verified clinical evidence.

Possible Forane side effects / adverse reactions in 2 year old male

Reported by a physician from Greece on 2011-10-14

Patient: 2 year old male

Reactions: Kounis Syndrome

Suspect drug(s):
    Indication: General Anaesthesia

Rocuronium Bromide
    Indication: General Anaesthesia

Other drugs received by patient: Cefazolin; Midazolam HCL; Fentanyl

Possible Forane side effects / adverse reactions in 29 year old male

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-08-09

Patient: 29 year old male

Reactions: Hyperthermia Malignant, Cardiac Arrest

Suspect drug(s):

Other drugs received by patient: Oxygen; Fentanyl; Nitrous Oxide

See index of all Forane side effect reports >>

Drug label data at the top of this Page last updated: 2011-12-15

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