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Forane (Isoflurane) - Drug Interactions, Contraindications, Overdosage, etc



Drug Interactions

Isoflurane potentiates the muscle relaxant effect of all muscle relaxants, most notably nondepolarizing muscle relaxants, and MAC (minimum alveolar concentration) is reduced by concomitant administration of NO. See CLINICAL PHARMACOLOGY


In the event of overdosage, or what may appear to be overdosage, the following action should be taken:

Stop drug administration, establish a clear airway, and initiate assisted or controlled ventilation with pure oxygen.


Known sensitivity to FORANE (isoflurane, USP) or to other halogenated agents. Known or suspected genetic susceptibility to malignant hyperthermia.


  1. J.C. Sill, et al, Anesthesiology 66:273-279, 1987
  2. R.F. Hickey, et al, Anesthesiology 68:21-30, 1988
  3. C.W. Buffington, et al, Anesthesiology 66:280-292, 1987
  4. S. Reiz, et al, Anesthesiology 59:91-97, 1983
  5. S. Slogoff and A.S. Keats, Anesthesiology 70:179-188, 1989
  6. K.J. Tuman, et al, Anesthesiology 70:189-198, 1989
  7. D.T. Mangano, Editorial Views, Anesthesiology 70:175-178, 1989

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