FORANE SUMMARY
FORANE (isoflurane, USP), a nonflammable liquid administered by vaporizing, is a general inhalation anesthetic drug.
FORANE (ISOFLURANE) is indicated for the following:
FORANE (isoflurane, USP) may be used for induction and maintenance of general anesthesia. Adequate data have not been developed to establish its application in obstetrical anesthesia.
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NEWS HIGHLIGHTS
Published Studies Related to Forane (Isoflurane)
Hypotensive anaesthesia with remifentanil combined with desflurane or isoflurane
in tympanoplasty or endoscopic sinus surgery: a randomised, controlled trial. [2008] loss, and recovery during tympanoplasty or endoscopic sinus surgery... CONCLUSION: Although desflurane and isoflurane both enabled good surgical
A comparison of equine recovery characteristics after isoflurane or isoflurane
followed by a xylazine-ketamine infusion. [2008] 30 kg... CONCLUSIONS: Under the conditions of this study, infusion of XYL and KET does not
Emergence and recovery in children after desflurane and isoflurane anaesthesia:
effect of anaesthetic duration. [2006] would be less marked with desflurane in comparison with isoflurane... CONCLUSIONS: The rate of recovery in children after exposure to desflurane was
Prophylactic nebulized lidocaine attenuates hyperdynamic response to abrupt mask
inhalation of isoflurane in adults. [2004] volatile anesthetic administration... CONCLUSION: Prophylactic ultrasonically nebulized lidocaine (2 mg/kg) obtunds the
Multicenter randomized comparison of the efficacy and safety of xenon and
isoflurane in patients undergoing elective surgery. [2003] CONCLUSION: This first randomized controlled multicenter trial on the use of
Clinical Trials Related to Forane (Isoflurane)
Sevoflurane vs. Isoflurane for Low-Flow General Anaesthesia for Abdominal Surgery [Completed]
Two groups of patients are going to have abdominal surgery with low-flow general
anaesthesia. Group A (sevoflurane group, experimental group) will use volatile anaesthetic
sevoflurane. Group B (isoflurane group, control group) will use volatile anaesthetic
isoflurane. It will be observed differences between volatile anaesthetic sevoflurane and
volatile anaesthetic isoflurane for providing low-flow general anaesthesia for abdominal
surgery. Duration of this randomised controled trial will be approximately 2 months.
Estimated sample size will be 82 persons (41 in sevoflurane group and 41 in isoflurane
group).
Post Anesthesia Emergence and Behavioral Changes in Children Undergoing MRI [Recruiting]
Children who receive general anesthesia may become agitated (emergence delirium) in the
recovery period. This occurs more often after inhalational anesthetics, particularly
sevoflurane and desflurane than after propofol. However, agitation after anesthesia in
children may be difficult to distinguish from pain; accordingly studies are ideally designed
during MRI to obviate the contribution of pain during emergence. Airway complications have
been reported after LMA and isoflurane more commonly than with IV propofol and nasal prongs.
Whether the airway complications were due to the LMA or the isoflurane was unclear.
Therefore, this study was designed to study the incidence of 1. agitation after sevoflurane
compared with IV propofol and 2. airway complications after LMA or nasal prongs.
Isoflurane at Subanesthetic Concentrations - 6 [Completed]
The purpose of this study is to conduct experiments to examine subjective and reinforcing
effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug
abusers and preference procedures will be used to assess reinforcing effects. To test the
hypothesis that isoflurane at subanesthetic concentrations does not reduce cold-water
immersion pain in healthy volunteers.
Isoflurane During Cardiopulmonary Bypass [Recruiting]
There is no clinical way of assessing the depth of anaesthesia while patients are on the
heart-lung machine. A new method of measuring the depth of anaesthesia using brainwaves
called the Bispectral index (BIS) has been developed and its use in cardiac surgery is now
widespread. However BIS is also altered by patients body temperature. As cooling is common
during heart surgery the use of BIS to measure the depth of anaesthesia during heart-lung
bypass remains controversial. This study aims to find out what depth of anaesthesia is
produced according to BIS during heart lung bypass using a standard anaesthetic technique
that utilises the anaesthetic isoflurane.
Effects of Subanesthetic Concentrations of Isoflurane/Nitrous Oxide - 3 [Completed]
The purpose of this study is to conduct experiments to examine subjective and reinforcing
effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug
abusers and preference procedures will be used to assess reinforcing effects. To evaluate
the acute and residual effects of subanesthetic concentrations of isoflurane/nitrous oxide
combinations in healthy volunteers.
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