DOSAGE AND ADMINISTRATION
Dosage and Schedule
Basic dosing information for Fluzone and Fluzone High-Dose, and their respective age indications, are presented in Table 1 and Table 2.
Table 1: Fluzone
| Vaccination Status and Age |
Dose/Route |
Schedule |
| Previously unvaccinated or incompletely vaccinated with an influenza vaccine (ie, no previous dose or vaccinated for the first time in the last influenza season and received only 1 dose) |
|
|
| 6 through 35 months |
0.25 mL/Intramuscular |
2 doses at least 1 month apart |
| 36 months through 8 years |
0.5 mL/Intramuscular |
2 doses at least 1 month apart |
| Previously vaccinated with an influenza vaccine (ie, received two doses last influenza season or one or more doses at any time before last season) |
|
|
| 6 through 35 months |
0.25 mL/Intramuscular |
1 dose |
| 36 months through 8 years |
0.5 mL/Intramuscular |
1 dose |
|
Any vaccination status
|
|
|
| 9 years and older |
0.5 mL/Intramuscular |
1 dose |
Table 2: Fluzone High-Dose
| Any vaccination status |
Dose/Route |
Schedule |
| 65 years and older |
0.5 mL/Intramuscular |
1 dose |
Administration
Inspect Fluzone and Fluzone High-Dose syringes and vials visually for particulate matter and/or discoloration prior to administration. If either of these conditions exist, the vaccine should not be administered.
Shake the syringe or single-dose vial before administering the vaccine and shake the multi-dose vial each time before withdrawing a dose of vaccine.
The vaccine should not be injected into the gluteal region or into areas where there may be a major nerve trunk. For needle length, refer to the Advisory Committee on Immunization Practices (ACIP) recommendations. (1)
If Fluzone or Fluzone High-Dose are to be given at the same time as another injectable vaccine(s), the vaccine(s) should always be administered at separate injection sites.
Pediatrics
The preferred sites for intramuscular injections are the anterolateral aspect of the thigh in infants (6-12 months of age) or the deltoid muscle of the upper arm in children (12 months through 17 years of age).
Adults 18 years of age and older
Fluzone should be administered as a single intramuscular dose preferably in the deltoid muscle.
Adults 65 years of age and older
Fluzone High-Dose should be administered as a single intramuscular dose preferably in the deltoid muscle.
DOSAGE FORMS AND STRENGTHS
Sterile suspension for intramuscular injection is supplied in 5 presentations: 4 presentations of Fluzone (including 2 dosage strengths in pre-filled syringes) and 1 presentation of Fluzone High-Dose in a pre-filled syringe. Dosage strengths of the 3 different pre-filled syringes are distinguished by different colored plungers.
Fluzone
Sterile suspension for intramuscular injection supplied in 4 presentations:
1) Prefilled syringe, 0.25 mL, pediatric dose, for 6 through 35 months of age, distinguished by a pink syringe plunger rod.
2) Prefilled syringe, 0.5 mL, for 36 months of age and older, distinguished by a clear syringe plunger rod.
3) Single-dose vial, 0.5 mL, for 36 months of age and older.
4) Multi-dose vial, 5 mL, for 6 months of age and older, contains thimerosal as a preservative. [See
Description
.]
Each 0.25 mL dose of Fluzone contains influenza split virus antigens that are formulated to contain a total of 22.5 mcg of influenza virus hemagglutinin, 7.5 mcg each from the 3 influenza virus strains in the vaccine. Each 0.5 mL dose of Fluzone contains influenza split virus antigens formulated to contain a total of 45 mcg of influenza virus hemagglutinin, 15 mcg each from the 3 influenza virus strains in the vaccine. [See
Description. ]
Fluzone High-Dose
Sterile suspension for intramuscular injection supplied in prefilled syringes, 0.5 mL, for adults 65 years of age and older, distinguished by a gray syringe plunger rod.
Each 0.5 mL dose of Fluzone High-Dose contains influenza split virus antigens that are formulated to contain a total of 180 mcg of influenza virus hemagglutinin, 60 mcg each from the 3 influenza virus strains in the vaccine. [See
Description. ]
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