Most adverse reactions are caused by the drug’s mineralocorticoid activity (retention of sodium and water) and include hypertension, edema, cardiac enlargement, congestive heart failure, potassium loss, and hypokalemic alkalosis.
When fludrocortisone is used in the small dosages recommended, the glucocorticoid side effects often seen with cortisone and its derivatives are not usually a problem; however the following untoward effects should be kept in mind, particularly when fludrocortisone is used over a prolonged period of time or in conjunction with cortisone or a similar glucocorticoid.
Musculoskeletal —muscle weakness, steroid myopathy, loss of muscle mass, osteoporosis, vertebral compression fractures, aseptic necrosis of femoral and humeral heads, pathologic fracture of long bones, and spontaneous fractures.
Gastrointestinal —peptic ulcer with possible perforation and hemorrhage, pancreatitis, abdominal distention, and ulcerative esophagitis.
Dermatologic —impaired wound healing, thin fragile skin, bruising, petechiae and ecchymoses, facial erythema, increased sweating, subcutaneous fat atrophy, purpura, striae, hyperpigmentation of the skin and nails, hirsutism, acneiform eruptions, and hives; reactions to skin tests may be suppressed.
Neurological —convulsions, increased intracranial pressure with papilledema (pseudotumor cerebri) usually after treatment, vertigo, headache, and severe mental disturbances.
Endocrine —menstrual irregularities; development of the cushingoid state; suppression of growth in children; secondary adrenocortical and pituitary unresponsiveness, particularly in times of stress (e.g., trauma, surgery, or illness); decreased carbohydrate tolerance; manifestations of latent diabetes mellitus; and increased requirements for insulin or oral hypoglycemic agents in diabetics.
Ophthalmic —posterior subcapsular cataracts, increased intraocular pressure, glaucoma, and exophthalmos.
Metabolic —hyperglycemia, glycosuria, and negative nitrogen balance due to protein catabolism.
Allergic Reactions —allergic skin rash, maculopapular rash, and urticaria.
Other adverse reactions that may occur following the administration of a corticosteroid are necrotizing angiitis, thrombophlebitis, aggravation or masking of infections, insomnia, syncopal episodes, and anaphylactoid reactions.
REPORTS OF SUSPECTED FLORINEF SIDE EFFECTS / ADVERSE REACTIONS
Below is a sample of reports where side effects / adverse reactions may be related to Florinef. The information is not vetted and should not be considered as verified clinical evidence.
Possible Florinef side effects / adverse reactions in 86 year old female
Reported by a consumer/non-health professional from United States on 2012-05-09
Patient: 86 year old female
Reactions: Death, Haemorrhage, International Normalised Ratio Increased, Anaemia, Deep Vein Thrombosis, Cardiac Failure Congestive
Adverse event resulted in: death, life threatening event, hospitalization
Dosage: 2.5 mg of coumadin 3 days a week and 5 mg on the other 4 days of the week.
Indication: Deep Vein Thrombosis
Dosage: taken off:20apr12
Other drugs received by patient: Cozaar; Coenzyme Q10; Vitamin D; Simvastatin; Insulin; Pepcid; Vitamin B Complex CAP; Iron Supplement
Possible Florinef side effects / adverse reactions in 98 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-23
Patient: 98 year old male weighing 81.5 kg (179.3 pounds)
Reactions: Swelling, Hypertension
Dosage: 0.1mg once daily po
Administration route: Oral
Dosage: 10mg three times daily po
Administration route: Oral