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Flonase (Fluticasone Propionate Nasal) - Summary

 
 



FLONASE SUMMARY

FLONASE®
(fluticasone propionate)
Nasal Spray, 50 mcg

For Intranasal Use Only. SHAKE GENTLY BEFORE USE.

Fluticasone propionate, the active component of FLONASE Nasal Spray, is a synthetic corticosteroid having the chemical name S-(fluoromethyl)6(alpha),9-difluoro-11(beta)-17-dihydroxy -16(alpha)-methyl-3-oxoandrosta-1,4-diene-17(beta)-carbothioate, 17-propionate.

FLONASE Nasal Spray is indicated for the management of the nasal symptoms of seasonal and perennial allergic and nonallergic rhinitis in adults and pediatric patients 4 years of age and older.

Safety and effectiveness of FLONASE Nasal Spray in children below 4 years of age have not been adequately established.


See all Flonase indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Flonase (Fluticasone Nasal)

Over-the-Counter Flonase Allergy Relief Approved
Source: MedicineNet Hay Fever Specialty [2014.07.29]
Title: Over-the-Counter Flonase Allergy Relief Approved
Category: Health News
Created: 7/29/2014 11:00:00 AM
Last Editorial Review: 7/29/2014 12:00:00 AM

Chronic Rhinitis and Post-Nasal Drip
Source: MedicineNet Indoor Allergens Specialty [2013.11.27]
Title: Chronic Rhinitis and Post-Nasal Drip
Category: Diseases and Conditions
Created: 7/13/1998 12:00:00 AM
Last Editorial Review: 11/27/2013 12:00:00 AM

Sublingual Immunotherapy Effective in Cat-allergic Patients
Source: Medscape Allergy & Clinical Immunology Headlines [2014.12.12]
Oral immunotherapy has once again been found safe and effective in patients with cat-induced allergic rhinitis and asthma.
Medscape Medical News

more news >>

Published Studies Related to Flonase (Fluticasone Nasal)

Efficacy, dose reduction, and resistance to high-dose fluticasone in patients with eosinophilic esophagitis. [2014]
esophagitis (EoE) and analyzed esophageal transcriptomes to identify mechanisms... CONCLUSIONS: Daily administration of a high dose of FP induces histologic

Fluticasone impact on airway dendritic cells in smokers: a randomized controlled trial. [2013]
DCs in smokers are unknown... CONCLUSIONS: Resistance to ICS monotherapy in smokers might in part be due to

An integrated analysis of the efficacy of fluticasone furoate nasal spray versus placebo on the nasal symptoms of perennial allergic rhinitis. [2013]
Intranasal corticosteroids are widely prescribed for the treatment of perennial allergic rhinitis (PAR). The aim of this analysis was to determine whether the beneficial effects of once-daily (q.d.) fluticasone furoate nasal spray (FFNS) effectively improved individual nasal symptoms of PAR...

MP29-02 (a novel intranasal formulation of azelastine hydrochloride and fluticasone propionate) in the treatment of seasonal allergic rhinitis: a randomized, double-blind, placebo-controlled trial of efficacy and safety. [2012]
Many patients with allergic rhinitis (AR) have uncontrolled symptoms despite available treatment options. This study was designed to evaluate the efficacy and safety of MP29-02 (a novel intranasal formulation of fluticasone propionate [FP] and azelastine [AZ] hydrochloride), compared with monotherapy with FP, AZ, and placebo sprays for the treatment of seasonal allergic rhinitis (SAR)...

Efficacy in asthma of once-daily treatment with fluticasone furoate: a randomized, placebo-controlled trial. [2011.10.06]
ABSTRACT: BACKGROUND: Fluticasone furoate (FF) is a novel long-acting inhaled corticosteroid (ICS). This double-blind, placebo-controlled randomized study evaluated the efficacy and safety of FF 200 mcg or 400 mcg once daily, either in the morning or in the evening, and FF 200 mcg twice daily (morning and evening), for 8 weeks in patients with persistent asthma... CONCLUSIONS: FF at total daily doses of 200 mcg or 400 mcg was significantly more effective than placebo. FF 400 mcg once daily in the evening had similar efficacy to FF 200 mcg twice daily and all FF regimens had a safety tolerability profile generally similar to placebo. This indicates that inhaled FF is an effective and well tolerated once-daily treatment for mild-to-moderate asthma. TRIAL REGISTRATION: NCT00398645.

more studies >>

Clinical Trials Related to Flonase (Fluticasone Nasal)

A 12-Month Study Comparing Fluticasone Propionate/Salmeterol (ADVAIR) DISKUS Combination Product 250/50mcg Twice Daily To Fluticasone Propionate (FLOVENT) DISKUS 250 Mcg Twice Daily In Symptomatic Patients With Asthma [Active, not recruiting]
This purpose of this study is to show the superiority and long term safety and efficacy of adding a long acting beta agonist (salmeterol) to constant dose of an inhaled corticosteroid (fluticasone propionate) in symptomatic subjects with asthma. The 12-month assessment of asthma control will provide key information on the efficacy and safety of the combination therapy. The safety measure will be an assessment of adverse events

A 12-Month Study Comparing Fluticasone Propionate/Salmeterol (ADVAIR) DISKUS Combination Product 250/50mcg BID To Fluticasone Propionate (FLOVENT) DISKUS 250 Mcg BID In Symptomatic Subjects With Asthma [Active, not recruiting]
This purpose of this study is to show the superiority and long term safety and efficacy of adding a long acting beta agonist (salmeterol) to constant dose of an inhaled corticosteroid (fluticasone propionate) in symptomatic subjects with asthma. The 12-month assessment of asthma control will provide key information on the efficacy and safety of the combination therapy. The safety measure will be an assessment of adverse events

Single Dose Pharmacokinetics of Intranasal Fluticasone Delivered by a Fixed Combination With Azelastine (MP29 02) in Comparison to Two Different Fluticasone Nasal Sprays [Recruiting]
The primary objective is to assess the effect of azelastine hydrochloride (AZE) on the relative bioavailability (AUC0-∞) of fluticasone propionate (FLU) when administered as fixed AZE-FLU combination product (TEST) compared to a similar formulation without containing AZE (i. e. FLU alone in the MP29-02 vehicle; REF).

The secondary objectives are to compare the relative bioavailability (AUC0-∞) of FLU when administered either as fixed AZE-FLU combination product (TEST) or as marketed FLU product, Fluticasone Propionate Nasal Spray, Roxane Laboratories (COMP); To compare the effects of AZE on other pharmacokinetic parameters of FLU (AUC0 tlast, CL/f, Cmax, tmax, t½); To assess adverse events.

Study HZA106829: Efficacy/Safety Study of Fluticasone Furoate/Vilanterol (GW642444) in Adult and Adolescent Asthmatics [Recruiting]
The purpose of the study is to compare the efficacy and safety of fluticasone furoate/vilanterol (GW642444) inhalation powder administered once daily each evening with fluticasone furoate inhalation powder administered alone once daily each evening in adolescent and adult subjects 12 years of age and older with persistent bronchial asthma over a 24-week period.

Repeat Dose Study of Fluticasone Propionate/Salmeterol Versus Fluticasone Propionate + Salmeterol In Asthmatics [Completed]
A new formulation of Fluticasone propionate/Salmeterol comparing a lower dose of fluticasone propionate and salmeterol was compared with concurrent administration of fluticasone propionate and salmeterol. Administration occurred over 14 days and tolerability, PK (pharmacokinetic) and PD (pharmacodynamic) measurements were performed.

more trials >>

Reports of Suspected Flonase (Fluticasone Nasal) Side Effects

Drug Ineffective (24)Epistaxis (12)Nasal Discomfort (8)Headache (8)Tendonitis (7)Pneumonia (7)Back Pain (6)Plantar Fasciitis (6)Peripheral Coldness (5)Palmar Fasciitis (5)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 30 ratings/reviews, Flonase has an overall score of 8.33. The effectiveness score is 8.67 and the side effect score is 9.07. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Flonase review by 46 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   allergies
Dosage & duration:   2 sprays in each nostril (dosage frequency: as needed) for the period of still taking it
Other conditions:   Mostly sinus pressure
Other drugs taken:   Claratin
  
Reported Results
Benefits:   This spray clears the nasal passages to promote free breathing. I've tried over the counter remedies but they are harsh and you end up practically addicted to them. This works much the same way but is non-addictive and need only be used when symptoms hit. I have used this same product when I've had a head cold and achieved the same results. I'm pretty sure that's not what it's intended for but whenever I've got sinus pressure, I take this product.
Side effects:   I've experienced no side effects.
Comments:   Simply shake the bottle, and use 2 sprays in each nostril daily.

 

Flonase review by 30 year old male patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   sinus allergy
Dosage & duration:   2 sprays daily (dosage frequency: daily) for the period of 2 weeks
Other conditions:   None
Other drugs taken:   None
  
Reported Results
Benefits:   Relief for my nasal clogging and breaht normally. Works great!
Side effects:   I've experienced no side effects, although there was some mild headache during the first day of use- this could have been due to other reasons.
Comments:   Moved to a new area with a lot of trees / greenry and experiecing temporary allergies while there. got prescribed flonase with dosage described above, and felt much better.

 

Flonase review by 20 year old female patient

  Rating
Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   allergies
Dosage & duration:   50 mcg twice per nostril (dosage frequency: once a day) for the period of 2 months
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   Effective inrelieving runny or clogged nose due to allergies, stops itchy,swelling and watering eyes.
Side effects:   Only lasted for 8 hours max, I was given specific instructions not to use more than once a day, so I still had to rely on over-the-counter pills after the 8 hours were up. Caused asthma in cold, dry weather and a very, very scratchy throat, as in physically having to scratch at my throat to relieve it. Worsened a pre-existing eczema condition.
Comments:   Used 2 pumps per nostril, once a day to relieve everyday allergies.

See all Flonase reviews / ratings >>

Page last updated: 2014-12-12

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