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Flonase (Fluticasone Propionate Nasal) - Summary

 
 



FLONASE SUMMARY

Fluticasone propionate, the active component of FLONASE Nasal Spray, is a synthetic corticosteroid.

FLONASE Nasal Spray is indicated for the management of the nasal symptoms of seasonal and perennial allergic and nonallergic rhinitis in adults and pediatric patients 4 years of age and older.

Safety and effectiveness of FLONASE Nasal Spray in children below 4 years of age have not been adequately established.

 


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NEWS HIGHLIGHTS

Media Articles Related to Flonase (Fluticasone Nasal)

Hay Fever (Allergic Rhinitis)
Source: MedicineNet Allergic Cascade Specialty [2015.08.18]
Title: Hay Fever (Allergic Rhinitis)
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 8/18/2015 12:00:00 AM

Chronic Rhinitis and Post-Nasal Drip
Source: MedicineNet Eustachian Tube Problems Specialty [2015.01.26]
Title: Chronic Rhinitis and Post-Nasal Drip
Category: Diseases and Conditions
Created: 7/13/1998 12:00:00 AM
Last Editorial Review: 1/26/2015 12:00:00 AM

more news >>

Published Studies Related to Flonase (Fluticasone Nasal)

Efficacy, dose reduction, and resistance to high-dose fluticasone in patients with eosinophilic esophagitis. [2014]
esophagitis (EoE) and analyzed esophageal transcriptomes to identify mechanisms... CONCLUSIONS: Daily administration of a high dose of FP induces histologic

Fluticasone impact on airway dendritic cells in smokers: a randomized controlled trial. [2013]
DCs in smokers are unknown... CONCLUSIONS: Resistance to ICS monotherapy in smokers might in part be due to

An integrated analysis of the efficacy of fluticasone furoate nasal spray versus placebo on the nasal symptoms of perennial allergic rhinitis. [2013]
Intranasal corticosteroids are widely prescribed for the treatment of perennial allergic rhinitis (PAR). The aim of this analysis was to determine whether the beneficial effects of once-daily (q.d.) fluticasone furoate nasal spray (FFNS) effectively improved individual nasal symptoms of PAR...

MP29-02 (a novel intranasal formulation of azelastine hydrochloride and fluticasone propionate) in the treatment of seasonal allergic rhinitis: a randomized, double-blind, placebo-controlled trial of efficacy and safety. [2012]
Many patients with allergic rhinitis (AR) have uncontrolled symptoms despite available treatment options. This study was designed to evaluate the efficacy and safety of MP29-02 (a novel intranasal formulation of fluticasone propionate [FP] and azelastine [AZ] hydrochloride), compared with monotherapy with FP, AZ, and placebo sprays for the treatment of seasonal allergic rhinitis (SAR)...

Efficacy in asthma of once-daily treatment with fluticasone furoate: a randomized, placebo-controlled trial. [2011.10.06]
ABSTRACT: BACKGROUND: Fluticasone furoate (FF) is a novel long-acting inhaled corticosteroid (ICS). This double-blind, placebo-controlled randomized study evaluated the efficacy and safety of FF 200 mcg or 400 mcg once daily, either in the morning or in the evening, and FF 200 mcg twice daily (morning and evening), for 8 weeks in patients with persistent asthma... CONCLUSIONS: FF at total daily doses of 200 mcg or 400 mcg was significantly more effective than placebo. FF 400 mcg once daily in the evening had similar efficacy to FF 200 mcg twice daily and all FF regimens had a safety tolerability profile generally similar to placebo. This indicates that inhaled FF is an effective and well tolerated once-daily treatment for mild-to-moderate asthma. TRIAL REGISTRATION: NCT00398645.

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Clinical Trials Related to Flonase (Fluticasone Nasal)

Effect of Flovent Discus vs QVAR vs Pulmicort Flexhaler on Short Term Growth [Recruiting]
Children with mild persistent asthma that have asthma symptoms once or twice a week and use a daily controller, while children with mild intermittent asthma rarely have asthma symptoms and do not use a daily controller. Inhaled corticosteroids are the standard treatment for mild peristent asthma. The purpose of this study is to measure children rate of growth while on different inhaled corticosteroids.

A 12-Month Study Comparing Fluticasone Propionate/Salmeterol (ADVAIR) DISKUS Combination Product 250/50mcg Twice Daily To Fluticasone Propionate (FLOVENT) DISKUS 250 Mcg Twice Daily In Symptomatic Patients With Asthma [Completed]
This purpose of this study is to show the superiority and long term safety and efficacy of adding a long acting beta agonist (salmeterol) to constant dose of an inhaled corticosteroid (fluticasone propionate) in symptomatic subjects with asthma. The 12-month assessment of asthma control will provide key information on the efficacy and safety of the combination therapy. The safety measure will be an assessment of adverse events

Single Dose Crossover Study of Patient Preference for Unscented Nasonex« Nasal Spray Versus Scented Flonase« Nasal Spray (Study P04207) [Completed]
This was a one-day single dose trial conducted to compare patient's preference for Nasonex« (mometasone) versus Flonase« nasal spray. Each patient was randomized to take one dose (2 sprays in each nostril) of Nasonex or Flonase. Thirty minutes later, each patient was to take one dose of the opposite medication. Questionnaires were given to each patient after each drug dose to evaluate patient product preference.

Single Dose Crossover Study of Patient Preference for Unscented Nasonex« Nasal Spray Versus Scented Flonase« Nasal Spray (Study P04208) [Completed]
This was a one-day single dose trial conducted to compare patient's preference for Nasonex« (mometasone) versus Flonase« nasal spray. Each patient was randomized to take one dose (2 sprays in each nostril) of Nasonex or Flonase. Thirty minutes later, each patient was to take one dose of the opposite medication. Questionnaires were given to each patient after each drug dose to evaluate patient product preference.

Sensitivity of Pharmacokinetics to Differences in Aerodynamic Particle Size Distribution [Recruiting]
When a drug company first develops a drug, the company has to show the Food and Drug Administration (FDA) that the drug is safe and effective. If FDA concludes that the drug is safe and effective, FDA approves the drug. The company can then sell the drug, which the company does using "trade name." Only the drug company that developed the "trade name" drug is allowed to sell it. However, other drug companies can create their own version of the "trade name" drug, which usually happens after the patents for the "trade name" product run out. These drugs, often called "generic drugs," potentially will be less expensive for the patient. In order to sell generic drugs, drug companies must show that their generic version is the same as the "trade name" drug in a number of ways. For example, they generally have to show that their product is intended to be used to treat the same diseases or conditions, that it has the same label, and that the product has the same active ingredient as the "trade name" drug. The generic company also has to show that generic product is "bioequivalent" to the trade name drug, meaning that the generic product gets to the part of the body where the drug works at the same rate that the trade name drug does. How to show how much drug gets to the part of the body where it works, and how fast, depends on the type of product the drug is. The primary aim of this research study is to aid the FDA in finding methods to ensure that the versions of generic drugs that are inhaled (for example, drugs used to treat asthma) are bioequivalent to the trade name drug. As a part of the research study, pharmacokinetic (PK) studies (studies measuring drug levels in the blood over time after inhalation) will be done using three different versions of fluticasone propionate (FP, a drug routinely used in asthmatic patients) administered using a dry powder inhaler (DPI, an inhalation device that delivers the drug as a dry powder). The results from this study will help FDA ensure that generic products are the same as the trade name drugs.

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Reports of Suspected Flonase (Fluticasone Nasal) Side Effects

Drug Ineffective (24)Epistaxis (12)Nasal Discomfort (8)Headache (8)Tendonitis (7)Pneumonia (7)Back Pain (6)Plantar Fasciitis (6)Peripheral Coldness (5)Palmar Fasciitis (5)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 30 ratings/reviews, Flonase has an overall score of 8.33. The effectiveness score is 8.67 and the side effect score is 9.07. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Flonase review by 46 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   allergies
Dosage & duration:   2 sprays in each nostril (dosage frequency: as needed) for the period of still taking it
Other conditions:   Mostly sinus pressure
Other drugs taken:   Claratin
  
Reported Results
Benefits:   This spray clears the nasal passages to promote free breathing. I've tried over the counter remedies but they are harsh and you end up practically addicted to them. This works much the same way but is non-addictive and need only be used when symptoms hit. I have used this same product when I've had a head cold and achieved the same results. I'm pretty sure that's not what it's intended for but whenever I've got sinus pressure, I take this product.
Side effects:   I've experienced no side effects.
Comments:   Simply shake the bottle, and use 2 sprays in each nostril daily.

 

Flonase review by 30 year old male patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   sinus allergy
Dosage & duration:   2 sprays daily (dosage frequency: daily) for the period of 2 weeks
Other conditions:   None
Other drugs taken:   None
  
Reported Results
Benefits:   Relief for my nasal clogging and breaht normally. Works great!
Side effects:   I've experienced no side effects, although there was some mild headache during the first day of use- this could have been due to other reasons.
Comments:   Moved to a new area with a lot of trees / greenry and experiecing temporary allergies while there. got prescribed flonase with dosage described above, and felt much better.

 

Flonase review by 20 year old female patient

  Rating
Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   allergies
Dosage & duration:   50 mcg twice per nostril (dosage frequency: once a day) for the period of 2 months
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   Effective inrelieving runny or clogged nose due to allergies, stops itchy,swelling and watering eyes.
Side effects:   Only lasted for 8 hours max, I was given specific instructions not to use more than once a day, so I still had to rely on over-the-counter pills after the 8 hours were up. Caused asthma in cold, dry weather and a very, very scratchy throat, as in physically having to scratch at my throat to relieve it. Worsened a pre-existing eczema condition.
Comments:   Used 2 pumps per nostril, once a day to relieve everyday allergies.

See all Flonase reviews / ratings >>

Page last updated: 2015-08-18

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