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Flomax (Tamsulosin Hydrochloride) - Summary

 


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FLOMAX SUMMARY

Tamsulosin hydrochloride is an antagonist of alpha1A adrenoceptors in the prostate.

FLOMAX® (tamsulosin HCl) capsules are indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH). FLOMAX capsules are not indicated for the treatment of hypertension.


See all Flomax indications & dosage >>

FLOMAX NEWS HIGHLIGHTS

Media Articles Related to Flomax (Tamsulosin)

Advisory: If You Have Taken Flomax(R), Tell Your Ophthalmologist BEFORE Having Cataract Surgery
Source: Hypertension News From Medical News Today [2009.06.12]
The results of a new study reinforce an advisory that patients taking Flomax® (Tamsulosin) to treat prostate enlargement and urinary problems should inform their ophthalmologist about their use of this drug before undergoing eye surgery. The advisory was issued by the American Academy of Ophthalmology (Academy) and the

Flomax Linked to Cataract Surgery Risks
Source: MedicineNet Benign Prostatic Hyperplasia Specialty [2009.05.20]
Title: Flomax Linked to Cataract Surgery Risks
Category: Health News
Created: 5/20/2009
Last Editorial Review: 5/20/2009

Postoperative PSA And PSA Velocity Identify Presence Of Prostate Cancer After Various Surgical Interventions For Benign Prostatic Hyperplasia
Source: Prostate / Prostate Cancer News From Medical News Today [2009.06.22]
UroToday.com - Men undergoing surgical interventions for BPH are still at risk for subsequent development of prostate cancer (CaP) due to residual tissue. It is suggested that PSA decreases approximately 0.1-0.3ng/ml for every 1g of prostate tissue removed. In the online edition of Urology, Dr.

Benign Prostatic Hyperplasia
Source: MedicineNet Prostatitis Specialty [2008.06.23]
Title: Benign Prostatic Hyperplasia
Category: Diseases and Conditions
Created: 12/31/1997
Last Editorial Review: 6/23/2008

Tadalafil May Effectively Treat Symptoms Of BPH-LUTS In Addition To Erectile Dysfunction
Source: Erectile Dysfunction / Premature Ejaculation News From Medical News Today [2009.04.27]
Tadalafil may improve lower urinary tract symptoms in men with benign prostatic hyperplasia (BPH). Researchers from Nashville, Dallas, San Antonia and Indianapolis presented these findings during the 104th Annual Scientific Meeting of the American Urological Association (AUA).

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Published Studies Related to Flomax (Tamsulosin)

Effects of serum PSA on efficacy of tolterodine extended release with or without tamsulosin in men with LUTS, including OAB. [2008.11]
OBJECTIVES: To evaluate the efficacy of tolterodine extended release (ER), tamsulosin [generic for Flomax], and tolterodine ER plus tamsulosin in men with symptoms of overactive bladder and benign prostatic hyperplasia stratified by prostate-specific antigen (PSA) level... CONCLUSIONS: The results of our study have shown that tolterodine ER was efficacious in men with lower urinary tract symptoms, including overactive bladder, who had lower PSA levels (<1.3 ng/mL).

Tamsulosin facilitates earlier clearance of stone fragments and reduces pain after shockwave lithotripsy for renal calculi: results from an open-label randomized study. [2008.11]
OBJECTIVES: To evaluate the role of tamsulosin [generic for Flomax] in the clearance of fragments after extracorporeal shock wave lithotripsy (ESWL) to treat renal calculi... CONCLUSIONS: The results of our study have shown that tamsulosin facilitates earlier clearance of fragments after ESWL to renal calculi and helps reduce the severity of the pain. It tended to facilitate spontaneous clearance of steinstrasse; however, this requires additional evaluation.

Extended-release tolterodine with or without tamsulosin in men with lower urinary tract symptoms and overactive bladder: effects on urinary symptoms assessed by the International Prostate Symptom Score. [2008.11]
OBJECTIVE: To evaluate the efficacy of tolterodine extended-release (ER) plus tamsulosin [generic for Flomax] on lower urinary tract symptoms (LUTS) as assessed by changes in the International Prostate Symptom Score (IPSS) in men who met symptom entry criteria for both overactive bladder (OAB) and benign prostatic hyperplasia (BPH) trials... CONCLUSIONS: In this distinct clinical research population of men who met traditional symptom entry criteria for both OAB and BPH trials, tolterodine ER + tamsulosin was significantly more effective than placebo in treating storage LUTS, including OAB symptoms. Tamsulosin monotherapy produced significant improvements in voiding LUTS.

Efficacy and safety of extended-release oxybutynin in combination with tamsulosin for treatment of lower urinary tract symptoms in men: randomized, double-blind, placebo-controlled study. [2008.09]
OBJECTIVE: To evaluate the efficacy and tolerability of extended-release oxybutynin in combination with the alpha1-blocker tamsulosin [generic for Flomax] in reducing lower urinary tract symptoms in men... CONCLUSION: In men with substantial storage symptoms, combination therapy with tamsulosin and extended-release oxybutynin demonstrated greater efficacy than and comparable safety and tolerability to tamsulosin monotherapy.

Effect of tolterodine extended release with or without tamsulosin on measures of urgency and patient reported outcomes in men with lower urinary tract symptoms. [2008.09]
PURPOSE: We evaluated the efficacy of tolterodine extended release and/or tamsulosin [generic for Flomax] on micturition related urgency episodes, urgency severity and patient reported outcomes in men who met entry criteria for prostatic enlargement and overactive bladder trials... CONCLUSIONS: Treatment with tolterodine extended release plus tamsulosin significantly improved urgency variables and patient reported outcomes in men meeting entry criteria for overactive bladder and prostatic enlargement trials.

more studies >>

Clinical Trials Related to Flomax (Tamsulosin)

Efficacy and Safety Study of Dutasteride and Tamsulosin Followed by Counseling on Flexible Dosing of Tamsulosin on as Needed Basis, to Treat Benign Prostatic Hyperplasia (BPH) [Active, not recruiting]
This study will investigate the efficacy and safety of treatment with Dutasteride (0. 5mg), administered once daily for one year in combination with Tamsulosin (0. 4mg), administered once daily for 3 months, followed by counseling on flexible dosing of Tamsulosin on an as needed basis, on the improvement of symptoms and clinical outcome in men with moderate to severe symptomatic benign prostatic hyperplasia (BPH). At each scheduled visit (3, 6, and 9 months), the subject will be counseled on withdrawal of Tamsulosin. After randomization, study visits are every 13 weeks for up to 53 Weeks. (Including Screening, (up to 7 clinic visits)

A Study With Combination Treatment (Tamsulosin Hydrochloride and Solifenacin Succinate) in Male Patients With LUTS/BPH [Completed]
The study will examine the efficacy,safety and tolerability of combination therapy of tamsulosin and solifenacin compared to placebo and monotherapy of tamsulosin and solifenacin in the treatment of males with LUTS associated with BPH.

The Efficacy of Tamsulosin in the Treatment of Ureteral Stones in Emergency Department Patients [Completed]
The purpose of this study is to determine the efficacy of the α-adrenergic antagonist tamsulosin in the treatment of adult emergency department (ED) patients with ureteral colic secondary to lower ureteral calculus. We hypothesize that there will be no difference in outcomes for subjects treated with and without tamsulosin.

An Effectiveness and Safety Study Comparing Oxybutynin Chloride Plus FLOMAX (Tamsulosin HCl) and Placebo Plus FLOMAX (Tamsulosin HCl) for the Treatment of Lower Urinary Tract Symptoms. [Completed]
The purpose of this study is to evaluate the safety and effectiveness of oxybutynin extended release tablets 10 mg plus tamsulosin HCl 0. 4 mg in the treatment of lower urinary tract symptoms as measured by change of the total International Prostate Symptom Score (I-PSS) from baseline to Week 12 or the Final Visit.

A Study To Compare Giving AVODART And FLOMAX Together Or In A Combination Capsule In The Fed And Fasted State [Completed]
AVODART and tamsulosin are to treat benign prostatic hyperplasia. Studies show that when given together, there is more improvement in symptoms than either drug alone. In this study, we are looking to see if the drugs work the same in the body when giving AVODART and FLOMAX at the same time compared to when they are given in a combination capsule in a fed and fasted state. This study will be in healthy adult males.

more trials >>

FLOMAX PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 1 ratings/reviews, Flomax has an overall score of 8. The effectiveness score is 8 and the side effect score is 6. The scores are on ten point scale: 10 - best, 1 - worst.
 

Flomax review by 48 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   kidney pain, difficult urination
Dosage & duration:   0.4 milligram (mg) once a day taken once a day for the period of One week was enough
Other conditions:   Chronic Fatigue Syndrome
Other drugs taken:   Antidepressants (wellbutrin, lexapro)
  
Reported Results
Benefits:   As near as we can tell, this drug (which is intended for men with enlarged prostates) relaxed ureter muscles, relieving the sensation of kidney stone pain, and also relaxed bladder muscles that had caused painful urination.
Side effects:   It made me drowsy all week; also sporadic dizziness. Chronic nasal congestion (stuffy nose) was also unpleasant.
Comments:   Once kidney stones were ruled out as the cause, the choices were to "wait it out," or to try this medication. Directions were pretty straightforward---take the pill after a meal; don't drive if feeling dizzy or drowsy; drink plenty of water.

See all Flomax reviews / ratings >>

Page last updated: 2009-06-22

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