NEWS HIGHLIGHTSMedia Articles Related to Flector (Diclofenac Topical)
New Use For Safety Reflector Technology In Detecting Bioterror Threats
Source: Bio-terrorism / Terrorism News From Medical News Today [2013.04.13]
Tiny versions of the reflectors on sneakers and bicycle fenders that help ensure the safety of runners and bikers at night are moving toward another role in detecting bioterrorism threats and diagnosing everyday infectious diseases, scientists said...
Keratosis Pilaris
Source: MedicineNet Atopic Dermatitis Specialty [2012.06.04]
Title: Keratosis Pilaris
Category: Diseases and Conditions
Created: 8/4/2008 12:00:00 AM
Last Editorial Review: 6/4/2012 12:00:00 AM
Published Studies Related to Flector (Diclofenac Topical)
Randomized, open-label, 5-way crossover study to evaluate the pharmacokinetic/pharmacodynamic interaction between furosemide and the non-steroidal anti-inflammatory drugs diclofenac and ibuprofen in healthy volunteers. [2011.08]
OBJECTIVE: Nonsteroidal anti-inflammatory drugs (NSAIDs) can induce renal complications in patients taking loop diuretics. This study investigated the pharmacokinetic/pharmacodynamic effects and safety profile of orally administered diclofenac sodium, ibuprofen and diclofenac epolamine topical patch (DETP) on furosemide in healthy adult subjects... CONCLUSIONS: Pharmacodynamic effects were seen with oral diclofenac (urine output) and ibuprofen (urine sodium excretion). Furosemide also affected plasma and urine pharmacokinetic profiles. Pharmacologic effects of DETP on furosemide were not observed under these conditions. Additional research is warranted to delineate the potential interactions of other NSAIDs with furosemide and other loop diuretics.
Comparison of topical 3% diclofenac sodium gel and 5% imiquimod cream for the treatment of actinic keratoses. [2011.07]
BACKGROUND: There is a wide spectrum of treatments available for actinic keratosis (AK). Topical diclofenac sodium and imiquimod are two topical treatments, which are noninvasive, easily applied, well-tolerated and effective. AIM: To compare the effects of topical 3% diclofenac sodium plus hyaluranon (DFS) gel, 5% imiquimod (IMQ) cream, and base cream (BC) in patients with AK... CONCLUSIONS: Although DFS and IMQ each had considerable efficacy in the treatment of AK, the efficacy of DFS seemed to decrease after cessation of treatment. (c) The Author(s). CED (c) 2011 British Association of Dermatologists.
A new topical formulation enhances relative diclofenac bioavailability in healthy male subjects. [2011.06]
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: * Therapy with topical non-steroidal anti-inflammatory drugs (NSAIDs) relies on the ability of the active drug to penetrate the skin in sufficiently high amounts to exert a clinical effect, which is linked to the specific galenic properties of the formulation. WHAT THIS STUDY ADDS: * This phase 1 study characterizes the transdermal penetration and plasma exposure of different dose levels with galenic differences of a novel topical diclofenac formulation under development and indicates greater diclofenac penetration through the skin when compared with a commercially available formulation. AIMS: To evaluate the relative plasma and tissue availability of diclofenac after repeated topical administration of a novel diclofenac acid-based delivery system under development (DCF100C)... CONCLUSION: DCF100C formulations were safe and facilitated greater diclofenac penetration through the skin compared with the commercial comparator. DCF100C represents a promising alternative to oral and topical diclofenac treatments that warrants further development. (c) 2011 The Authors. British Journal of Clinical Pharmacology (c) 2011 The British Pharmacological Society.
A comparative subjective assessment study of PENNSAID(R) and Voltaren Gel(R), two topical formulations of diclofenac sodium. [2011.05]
Osteoarthritis (OA) is a chronic degenerative joint disease that is debilitating for many individuals... Mean subjective responses to topical diclofenac solution with DMSO were also more favorable for most items in the questionnaire, and more subjects preferred or highly preferred topical diclofenac solution with DMSO over diclofenac sodium gel.
Effect of preemptive topical diclofenac on postoperative pain relief after photorefractive keratectomy. [2011.04]
PURPOSE: To assess the prophylactic effect of preoperative application of topical diclofenac on postoperative pain control in patients having photorefractive keratectomy (PRK). SETTING: Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran. DESIGN: Randomized masked clinical trial... CONCLUSION: Administration of a single drop of topical diclofenac 0.1% 2 hours before PRK seemed to increase the efficacy of postoperative pain management in a clinically and statistically significant manner. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned. Copyright (c) 2011 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.
Clinical Trials Related to Flector (Diclofenac Topical)
A Study Comparing Diclofenac Sodium Gel 3% to Solaraze� Gel 3% in the Treatment of Actinic Keratosis [Recruiting]
The objective of this study is to compare the relative efficacy and safety of the test
formulation diclofenac sodium gel 3% (Taro Pharmaceuticals Inc.) to the marketed formulation
Solaraze® (diclofenac sodium) Gel 3% (Fougera Pharms) in the treatment of actinic keratosis.
Both the test and reference formulations will also be compared to a placebo formulation to
test for superiority.
Effects of Pennsaid on Clinical Neuropathic Pain [Recruiting]
The purpose of this study is to see if the drug Pennsaid (Diclofenac) can help reduce pain
felt by people with chronic nerve pain. The drug will be used 2-4 times each day for 2
weeks.
The U. S. Food and Drug Administration (FDA) has approved Pennsaid to treat osteoarthritis
(bone pain), but the FDA has not approved Pennsaid to treat neuropathic (nerve) pain.
The research study will compare Pennsaid to placebo.
Treatment Study Topical NSAID, PENNSAID and Effect on Coagulation Values in Patients With Osteoarthritis Knee Pain Taking Warfarin [Recruiting]
Open-label active treatment Phase III study of PENNSAID (diclofenac sodium solution topical)
to determine the effects on coagulation parameters, (PT, PTT, INR) in 2 subgroups of
patients who have moderate to severe osteoarthritis (OA) pain of the knee currently on a
stable dose of warfarin and are:
- equal to 55 or > and < than or equal to 74 years of age;
- or equal to 75 years of age and above
The objective of this study is to see if the use of PENNSAID (a topical NSAID) to treat your
OA knee pain will not interfere with your current anticoagulant therapy or change your
laboratory values from their baseline values.
Comparison of the Effect of Etoricoxib and Diclofenac on Early Morning Activity in Rheumatoid Arthritis (RA) [Not yet recruiting]
The purpose of this study is to explore the effect of Etoricoxib compared to Diclofenac on
physical activity in RA subjects with early morning pain and stiffness.
Efficacy of Diclofenac on Pain During Endometrial Sampling [Recruiting]
Abnormal uterine bleeding is common in Thai women. Traditionally, because of a larger number
of patients, the diagnosis of its cause is performed via fractional curettage under local
anesthesia such as paracervical nerve block or intravenous meperidine.
Pain is one of a common adverse effect of this procedure and this topic should be concerned
by a responsible doctor.
NSAIDs, Diclofenac Potassium in this study, is known as a drug which is effective for pain
control and is as effective as coxib in acute pain management. Because of its cost, easy
accessible and easy administration, Diclofenac Potassium was selected to be used in this
study. Its onset of action is about 1 hour and only one dose of this drug do not cause any
serious side effects.
The hypothesis of this study is that "Diclofenac Potassium has an additional effectiveness
for acute pain control in patients undergoing fractional curettage under paracervical nerve
block due to abnormal uterine bleeding" Double blind randomised controlled trial was
performed in this study with 45 patients included in each group.
Reports of Suspected Flector (Diclofenac Topical) Side Effects
Drug Ineffective (201),
Pain (53),
Dizziness (43),
Nausea (39),
Rash (32),
Pruritus (29),
Headache (25),
Abdominal Discomfort (23),
Malaise (23),
Application Site Pain (17), more >>
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