Finacea (Azelaic Acid) - Summary

FINACEA SUMMARY

Finacea^®
(azelaic acid) Gel, 15%

FINACEA™ (azelaic acid) Gel, 15%, contains azelaic acid, a naturally occurring saturated dicarboxylic acid.

FINACEA™ Gel, 15%, is indicated for topical treatment of inflammatory papules and pustules of mild to moderate rosacea. Patients should be instructed to avoid spicy foods, thermally hot foods and drinks, alcoholic beverages and to use only very mild soaps or soapless cleansing lotion for facial cleansing.

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NEWS HIGHLIGHTS

Published Studies Related to Finacea (Azelaic Acid)

Combination of azelaic acid 5% and clindamycin 2% for the treatment of acne vulgaris. [2011]
vulgaris... CONCLUSION: The profound reduction in lesion count and ASI by

Efficacy of 15% azelaic acid in psoriasis vulgaris: a randomized, controlled clinical trial. [2010.08]
BACKGROUND: Psoriasis is a common disorder affecting 1-3 percent of the general global population...

Efficacy of topical azelaic acid (AzA) gel 15% plus oral doxycycline 40 mg versus metronidazole gel 1% plus oral doxycycline 40 mg in mild-to-moderate papulopustular rosacea. [2010.06]
Rosacea is a leading reason why people seek the care of a dermatologist, accounting for nearly 7 million office visits annually. Pharmacologic treatments include both topical and oral medications, which are increasingly being used in combination, especially at the outset of therapy... These findings warrant further investigation in a sufficiently powered study.

Combination of azelaic acid 5% and erythromycin 2% in the treatment of acne vulgaris. [2010.05]
INTRODUCTION: Acne vulgaris is a common problem, particularly among adolescents, which is usually resistant to monotherapy. We evaluated the efficacy and safety of a combination of azelaic acid (AA) 5% and erythromycin 2% gel (AzE) compared with AA 20% or erythromycin 2% gels in facial acne vulgaris... CONCLUSIONS: The combination of AA 5% and erythromycin 2% produced more potent therapeutic effects in comparison with erythromycin 2% or AA 20% alone, and with fewer side effects.

A multicenter study of topical azelaic acid 15% gel in combination with oral doxycycline as initial therapy and azelaic acid 15% gel as maintenance monotherapy. [2009.07]
This two-phase, multicenter study was undertaken to examine the safety and efficacy of combination therapy with oral doxycycline and topical azelaic acid (AzA) 15% gel in moderate-to-severe papulopustular rosacea and to determine the effect of subsequent maintenance monotherapy with AzA 15% gel alone...

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Clinical Trials Related to Finacea (Azelaic Acid)

Study for Long-term Treatment of Acne Vulgaris With Skinoren Versus Differin [Recruiting]
The purpose of this study is to assess the effect of Skinoren® 15% gel compared to no therapy on the maintenance of clinical therapy success in subjects with mild to moderate acne vulgaris previously treated for 3 months by a monotherapy of this substance and to assess the effect of Skinoren® 15% gel, compared to Differin® 0. 1% gel on the efficacy and safety during a 9-month long-term treatment period.

Azelaic Acid Iontophoresis Versus Topical Azelaic Acid Cream in the Treatment of Melasma [Recruiting]
The purpose of this prospective, randomized, controlled, single-blinded investigation is to study the efficacy, tolerability and safety of azelaic acid iontophoresis (AAI) versus topical treatment with azelaic acid cream in female patients with melasma.

Azelaic Acid Versus Hydroquinone in Melasma [Recruiting]

Efficacy and Safety Study Comparing CD07805/47 Gel 0.5% to Azelaic Acid Gel 15% in Subjects With Erythema of Rosacea [Recruiting]
The purpose of this study is to compare the efficacy and assess the safety of CD07805/47 gel 0. 5% applied topically once daily versus azelaic acid gel 15% applied topically twice daily in subjects with moderate to severe facial erythema of rosacea.

Safety and Efficacy of Azelaic Acid Foam, 15% in Papulopustular Rosacea [Recruiting]
The purpose of this study is to assess the safety and efficacy of Azelaic Acid Foam, 15% topically applied twice daily for 12 weeks in subjects with papulopustular rosacea compared to its vehicle.

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Reports of Suspected Finacea (Azelaic Acid) Side Effects

Burning Sensation (10),  Erythema (9),  Pruritus (6),  Skin Burning Sensation (6),  Pain (5),  Acne (5),  NO Adverse Event (5),  Skin Exfoliation (4),  Skin Discolouration (4),  Pain of Skin (4), more >>

PATIENT REVIEWS / RATINGS / COMMENTS

Finacea review by 42 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		mild acne
Dosage & duration:		very small amount over affected area (dosage frequency: am and pm) for the period of 5 months
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		the inflammation and redness around chin area was almost entirely cured, the skin was softer and smoother.
Side effects:		none in my case
Comments:		after applying the cream over breakout or redness at night before bed there was visible improvement over night, after a week of using the cream the breakouts were gone, skin was healed after 2 weeks.

Finacea review by 50 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		Acne
Dosage & duration:		thin layer (dosage frequency: twice daily) for the period of still using
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		The occurance of medium to large acne on cheeks was almost non existant. There still was the occasional small white head and they generally healed quickly and left little to no scarring.
Side effects:		There were no visible side effects that I was aware of. My only complaint was that it took about 3 months before I noticed that the occurance of medium to large pimples had stopped.
Comments:		pea size amount massaged into cheeks twice daily

Finacea review by 46 year old female patient
		Rating
Overall rating:
Effectiveness:		Moderately Effective
Side effects:		Severe Side Effects
		Treatment Info
Condition / reason:		ROSACEA
Dosage & duration:		TWICE DAILY (dosage frequency: 6 months) for the period of 6 MONTHS
Other conditions:		NONE
Other drugs taken:		NONE
		Reported Results
Benefits:		DECREASED REDNESS
Side effects:		HIGHLY IRRITATED AND DRY SKIN
Comments:		NONE