Feldene (Piroxicam) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

In patients taking FELDENE or other NSAIDs, the most frequently reported adverse experiences occurring in approximately 1–10% of patients are:

•   Cardiovascular System: Edema.
•   Digestive System: Anorexia, abdominal pain, constipation, diarrhea, dyspepsia, elevated liver enzymes, flatulence, gross bleeding/perforation, heartburn, nausea, ulcers (gastric/duodenal), vomiting.
•   Hemic and Lymphatic System: Anemia, increased bleeding time.
•   Nervous System: Dizziness, headache.
•   Skin and Appendages: Pruritus, rash.
•   Special Senses: Tinnitus.
•   Urogenital System: Abnormal renal function.

Additional adverse experiences reported occasionally include:

•   Body As a Whole: Fever, infection, sepsis.
•   Cardiovascular System: Congestive heart failure, hypertension, tachycardia, syncope.
•   Digestive System: Dry mouth, esophagitis, gastritis, glossitis, hematemesis, hepatitis, jaundice, melena, rectal bleeding, stomatitis.
•   Hemic and Lymphatic System: Ecchymosis, eosinophilia, epistaxis, leukopenia, purpura, petechial rash, thrombocytopenia.
•   Metabolic and Nutritional: Weight changes.
•   Nervous System: Anxiety, asthenia, confusion, depression, dream abnormalities, drowsiness, insomnia, malaise, nervousness, paresthesia, somnolence, tremors, vertigo.
•   Respiratory System: Asthma, dyspnea.
•   Skin and Appendages: Alopecia, bruising, desquamation, erythema, photosensitivity, sweat.
•   Special Senses: Blurred vision.
•   Urogenital System: Cystitis, dysuria, hematuria, hyperkalemia, interstitial nephritis, nephrotic syndrome, oliguria/polyuria, proteinuria, renal failure.

Other adverse reactions which occur rarely are:

•   Body As a Whole: Anaphylactic reactions, appetite changes, death, flu-like syndrome, pain (colic), serum sickness.
•   Cardiovascular System: Arrhythmia, exacerbation of angina, hypotension, myocardial infarction, palpitations, vasculitis.
•   Digestive System: Eructation, liver failure, pancreatitis.
•   Hemic and Lymphatic System: Agranulocytosis, hemolytic anemia, aplastic anemia, lymphadenopathy, pancytopenia.
•   Hypersensitivity: Positive ANA.
•   Metabolic and Nutritional: Hyperglycemia, hypoglycemia.
•   Nervous System: Akathisia, convulsions, coma, hallucinations, meningitis, mood alterations.
•   Respiratory: Respiratory depression, pneumonia.
•   Skin and Appendages: Angioedema, toxic epidermal necrosis, erythema multiforme, exfoliative dermatitis, onycholysis, Stevens-Johnson syndrome, urticaria, vesiculobullous reaction.
•   Special Senses: Conjunctivitis, hearing impairment, swollen eyes.

REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO FELDENE

Possible Feldene side effects / adverse reactions in 41 year old male

Reported by a individual with unspecified qualification from United States on 2007-03-12

Patient: 41 year old male

Reactions: Blood Pressure Increased, Medication Error, Chest Pain, Wrong Drug Administered, Drug Dispensing Error

Suspect drug(s):
Feldene
    Dosage: capsule

Felodipine
    Dosage: tablet, extended release

Possible Feldene side effects / adverse reactions in 15 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2007-03-16

Patient: 15 year old male weighing 57.0 kg (125.4 pounds)

Reactions: Duodenal Ulcer Perforation, Peritonitis

Adverse event resulted in: life threatening event

Suspect drug(s):
Feldene
    Administration route: Oral
    Indication: Abdominal Pain
    Start date: 2007-02-07
    End date: 2007-02-14

Domperidone
    Indication: Abdominal Pain
    Start date: 2007-02-07
    End date: 2007-02-14

Spasfon
    Dosage: text:3 df
    Administration route: Oral
    Indication: Abdominal Pain
    Start date: 2007-02-07
    End date: 2007-02-14

Possible Feldene side effects / adverse reactions in 62 year old female

Reported by a physician from Spain on 2007-04-02

Patient: 62 year old female

Reactions: Diarrhoea, Oesophageal Disorder, Gastrointestinal Disorder, Deafness, Toxic Epidermal Necrolysis, Tracheal Ulcer, Blindness

Adverse event resulted in: hospitalization, disablity

Suspect drug(s):
Feldene
    Administration route: Oral
    Indication: Arthralgia
    Start date: 2005-06-19
    End date: 2005-06-24

Feldene
    Indication: Inflammation

Feldene
    Indication: Osteoarthritis

Other drugs received by patient: Xicil; Acetaminophen; Omeprazole