Feldene (Piroxicam) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

In patients taking FELDENE or other NSAIDs, the most frequently reported adverse experiences occurring in approximately 1–10% of patients are:

•   Cardiovascular System: Edema.
•   Digestive System: Anorexia, abdominal pain, constipation, diarrhea, dyspepsia, elevated liver enzymes, flatulence, gross bleeding/perforation, heartburn, nausea, ulcers (gastric/duodenal), vomiting.
•   Hemic and Lymphatic System: Anemia, increased bleeding time.
•   Nervous System: Dizziness, headache.
•   Skin and Appendages: Pruritus, rash.
•   Special Senses: Tinnitus.
•   Urogenital System: Abnormal renal function.

Additional adverse experiences reported occasionally include:

•   Body As a Whole: Fever, infection, sepsis.
•   Cardiovascular System: Congestive heart failure, hypertension, tachycardia, syncope.
•   Digestive System: Dry mouth, esophagitis, gastritis, glossitis, hematemesis, hepatitis, jaundice, melena, rectal bleeding, stomatitis.
•   Hemic and Lymphatic System: Ecchymosis, eosinophilia, epistaxis, leukopenia, purpura, petechial rash, thrombocytopenia.
•   Metabolic and Nutritional: Weight changes.
•   Nervous System: Anxiety, asthenia, confusion, depression, dream abnormalities, drowsiness, insomnia, malaise, nervousness, paresthesia, somnolence, tremors, vertigo.
•   Respiratory System: Asthma, dyspnea.
•   Skin and Appendages: Alopecia, bruising, desquamation, erythema, photosensitivity, sweat.
•   Special Senses: Blurred vision.
•   Urogenital System: Cystitis, dysuria, hematuria, hyperkalemia, interstitial nephritis, nephrotic syndrome, oliguria/polyuria, proteinuria, renal failure.

Other adverse reactions which occur rarely are:

•   Body As a Whole: Anaphylactic reactions, appetite changes, death, flu-like syndrome, pain (colic), serum sickness.
•   Cardiovascular System: Arrhythmia, exacerbation of angina, hypotension, myocardial infarction, palpitations, vasculitis.
•   Digestive System: Eructation, liver failure, pancreatitis.
•   Hemic and Lymphatic System: Agranulocytosis, hemolytic anemia, aplastic anemia, lymphadenopathy, pancytopenia.
•   Hypersensitivity: Positive ANA.
•   Metabolic and Nutritional: Hyperglycemia, hypoglycemia.
•   Nervous System: Akathisia, convulsions, coma, hallucinations, meningitis, mood alterations.
•   Respiratory: Respiratory depression, pneumonia.
•   Skin and Appendages: Angioedema, toxic epidermal necrosis, erythema multiforme, exfoliative dermatitis, onycholysis, Stevens-Johnson syndrome, urticaria, vesiculobullous reaction.
•   Special Senses: Conjunctivitis, hearing impairment, swollen eyes.

REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO FELDENE

Possible Feldene side effects / adverse reactions in 65 year old female

Reported by a physician from France on 2009-07-16

Patient: 65 year old female weighing 69.0 kg (151.8 pounds)

Reactions: Bone Marrow Failure, Pancytopenia, Pyrexia

Adverse event resulted in: hospitalization

Suspect drug(s):
Alphagan
    Dosage: unk, bid
    Indication: Drug USE FOR Unknown Indication
    Start date: 2006-01-01
    End date: 2006-03-29

Feldene
    Administration route: Oral
    Indication: Drug USE FOR Unknown Indication
    Start date: 2008-10-01
    End date: 2008-10-01

Flecainide Acetate
    Dosage: 200 mg, qd
    Administration route: Oral
    Indication: Drug USE FOR Unknown Indication
    Start date: 2003-01-15
    End date: 2006-03-29

Piroxicam
    Dosage: 200 mg, single
    Administration route: Oral
    Indication: Drug USE FOR Unknown Indication
    End date: 2006-03-01

Tanakan
    Dosage: unk, tid
    Administration route: Oral
    Indication: Drug USE FOR Unknown Indication
    Start date: 2000-01-01
    End date: 2006-03-29

Utrogestan
    Dosage: unk, qd
    Administration route: Oral
    Indication: Drug USE FOR Unknown Indication
    End date: 2006-03-29

Xalatan
    Dosage: 2 gtt, qd
    Indication: Drug USE FOR Unknown Indication
    Start date: 2006-01-01
    End date: 2006-03-29

Possible Feldene side effects / adverse reactions in 65 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2009-11-09

Patient: 65 year old female

Reactions: Epstein-Barr Virus Infection, Aplastic Anaemia, Bone Marrow Failure, Pancytopenia, Pyrexia, Ill-Defined Disorder, Inflammation

Adverse event resulted in: hospitalization

Suspect drug(s):
Alphagan
    Dosage: daily dose: 2 dosage form
    Indication: Drug USE FOR Unknown Indication
    Start date: 2006-01-01
    End date: 2006-03-29

Feldene
    Dosage: daily dose: unknown
    Indication: Drug USE FOR Unknown Indication
    Start date: 2008-10-01
    End date: 2008-10-01

Flecainide Acetate
    Dosage: daily dose: 200 milligram(s)
    Administration route: Oral
    Indication: Drug USE FOR Unknown Indication
    Start date: 2003-01-15
    End date: 2006-03-29

Piroxicam
    Dosage: daily dose: 200 milligram(s)
    Administration route: Oral
    Indication: Drug USE FOR Unknown Indication
    End date: 2006-03-01

Tanakan
    Dosage: daily dose: 3 dosage form
    Administration route: Oral
    Indication: Drug USE FOR Unknown Indication
    Start date: 2000-01-01
    End date: 2006-03-29

Utrogestan
    Dosage: daily dose: 1 dosage form
    Administration route: Oral
    Indication: Drug USE FOR Unknown Indication
    End date: 2006-03-29

Possible Feldene side effects / adverse reactions in 66 year old female

Reported by a consumer/non-health professional from Brazil on 2009-11-10

Patient: 66 year old female weighing 90.0 kg (198.0 pounds)

Reactions: Femur Fracture, Drug Dispensing Error, Fall, Sciatic Nerve Neuropathy

Suspect drug(s):
Feldene
    Dosage: one administration weekly
    Indication: Musculoskeletal Pain
    Start date: 2008-01-01

Neurontin
    Dosage: one administration weekly
    Indication: Musculoskeletal Pain
    Start date: 2008-01-01

Other drugs received by patient: Tofranil; Azopt; Combigan; Xalatan