(brand of floxuridine)
FOR INTRA-ARTERIAL INFUSION ONLY
Sterile FUDR (floxuridine), an antineoplastic antimetabolite, is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. Each vial contains 500 mg of floxuridine which is to be reconstituted with 5 mL of sterile Water for Injection. An appropriate amount of reconstituted solution is then diluted with a parenteral solution for intra-arterial infusion (see DOSAGE AND ADMINISTRATION section).
Floxuridine is a fluorinated pyrimidine. Chemically, floxuridine is 2’-deoxy-5-fluorouridine with an empirical formula of C9H11FN2O5. It is a white to off-white odorless solid which is freely soluble in water.
The 2% aqueous solution has a pH of between 4.0 and 5.5. The molecular weight of floxuridine is 246.19 and the structural formula is: