NEWS HIGHLIGHTS
Published Studies Related to Famvir (Famciclovir)
Evaluation of orally administered famciclovir in cats experimentally infected with feline herpesvirus type-1. [2011.01]
OBJECTIVE: To evaluate orally administered famciclovir for treatment of cats with experimentally induced disease attributable to feline herpesvirus type-1 (FHV-1)...
One-day famciclovir vs. placebo in patient-initiated episodic treatment of recurrent genital herpes in immunocompetent Black patients. [2010.03]
BACKGROUND: There are no known racial differences in genital herpes disease pathogenesis or response to therapy. Despite high herpes simplex virus (HSV) seroprevalence in Black persons, clinical trials investigating the treatment of recurrent genital herpes (RGH) have typically enrolled a small proportion of Black patients... CONCLUSION: This study showed similar efficacy and tolerability of 1-day treatment with famciclovir 1000 mg twice-daily compared to placebo in immunocompetent Black adults with RGH. Famciclovir has proven efficacy and safety in the overall RGH population. Further understanding of the efficacy of antiherpes therapy in Black patients with recurrent genital herpes may be warranted.
One-day famciclovir vs. placebo in patient-initiated episodic treatment of
recurrent genital herpes in immunocompetent Black patients. [2010]
Black patients... CONCLUSION: This study showed similar efficacy and tolerability of 1-day
Single-day famciclovir for the treatment of genital herpes: follow-up results of time to next recurrence and assessment of antiviral resistance. [2009.02]
BACKGROUND: Episodic therapy of genital herpes is usually recommended for patients with infrequent symptomatic recurrences and where transmission is not a concern. While shorter courses are as effective as standard 5-day regimens, it is unknown whether abbreviated therapy has detrimental effects on natural history and the development of antiviral resistance. OBJECTIVES: To assess time to next recurrence and development of antiviral resistance in patients with recurrent genital herpes treated with either single-day famciclovir (1 g twice-daily) or 3-day valacyclovir (500 mg twice-daily)... CONCLUSION: Treatment with single-day famciclovir for recurrent genital herpes did not shorten the time to the next recurrence. Drug resistance to penciclovir continues to be a rare event in immunocompetent patients.
Pharmacokinetics and safety of penciclovir following oral administration of famciclovir to cats. [2007.11]
OBJECTIVE: To investigate penciclovir pharmacokinetics following single and multiple oral administrations of famciclovir to cats.Famciclovir dosages of 15 mg/kg administered every 8 hours to cats are unlikely to result in plasma penciclovir concentrations with activity against feline herpesvirus-1.
Clinical Trials Related to Famvir (Famciclovir)
Famvir for Treatment of Hearing in Unilateral Meniere's Disease [Recruiting]
The specific aim of this study is to determine the efficacy of treatment with famciclovir in
unilateral Meniere's Disease patients, specifically whether hearing can be improved. The
investigators will determine the percentage of unilateral Meniere's Disease patients
experiencing an absence of hearing fluctuation after 3 months of treatment with famciclovir
as compared to the placebo arm.
Famciclovir Pediatric Formulation in Children 1 to 12 Years of Age With Herpes Simplex Infection [Completed]
Herpes simplex virus causes cold sores (fever blisters) and can lead to painful lesions in
the mouth in healthy children. Children with impaired immune systems might develop severe
complications. Famciclovir is a drug approved to treat herpes simplex and varicella zoster
infection in adults. This study will evaluate the safety and blood levels of a new pediatric
formulation of Famvir in children 1-12 years of age.
Efficacy of Oral Famciclovir Versus Aciclovir Treatment in Patients With Herpes Zoster [Not yet recruiting]
Herpes Zoster is an infection that affects part of the nervous system caused by Varicella
Zoster Virus. Herpes Zoster manifests as vesicular eruption in the dermatome, often
associated with significant pain.
There are effective oral prescription antiviral medicines available to reduce the discomfort
of symptoms as famciclovir and aciclovir.
This is a phase III, multicenter, randomized, parallel-group study to compare the efficacy
and safety of treatment with Famciclovir (500 mg) comparing to Aciclovir (400 mg) in
patients with Herpes Zoster.
Efficacy of Oral Famciclovir 125mg Comparing to Aciclovir 200 mg Treatment in Patients With Active Recurrent Genital Herpes [Not yet recruiting]
Recurrent genital herpes is a commonly occurring sexually transmitted disease caused by
herpes simplex virus (HSV). There are effective oral prescription antiviral medicines
available to reduce the discomfort of symptoms as famciclovir and aciclovir.
This is a phase III, multicenter, randomized, parallel-group study to compare the efficacy
and safety of treatment with famciclovir (125 mg) comparing to aciclovir (200 mg) in
patients with active recurrent genital herpes.
Efficacy and Safety of Oral Famciclovir in Patients With Active Recurrent Genital Herpes [Completed]
This is a phase III, multicenter, randomized, double-blind, parallel-group study to compare
the efficacy and safety of a two-day treatment with famciclovir (500 mg loading dose followed
by 250 mg 12-hourly) to standard five-day treatment with famciclovir (125 mg 12-hourly) in
patients with active recurrent genital herpes.
This study is not recruiting patients in the United States.
Reports of Suspected Famvir (Famciclovir) Side Effects
Loss of Consciousness (16),
Rhabdomyolysis (8),
Malaise (7),
Dizziness (7),
Fall (6),
Convulsion (5),
Cerebral Infarction (5),
Altered State of Consciousness (5),
Asthenia (5),
Blood Pressure Decreased (5), more >>
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