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Famvir (Famciclovir) - Summary

 
 



FAMVIR SUMMARY

The active ingredient in FAMVIR tablets is famciclovir, an orally administered prodrug of the antiviral agent penciclovir.

Immunocompetent Adult Patients

Herpes l abialis ( c old s ores): FAMVIR is indicated for the treatment of recurrent herpes labialis.

Genital h erpes:  

Recurrent e pisodes: FAMVIR is indicated for the treatment of recurrent episodes of genital herpes. The efficacy of FAMVIR when initiated more than 6 hours after onset of symptoms or lesions has not been established.

Suppressive t herapy: FAMVIR is indicated for chronic suppressive therapy of recurrent episodes of genital herpes. The efficacy and safety of FAMVIR for the suppression of recurrent genital herpes beyond 1 year have not been established.

Herpes z oster (shingles) : FAMVIR is indicated for the treatment of herpes zoster. The efficacy of FAMVIR when initiated more than 72 hours after onset of rash has not been established.

HIV-Infected Adult Patients

Recurrent orolabial or genital herpes : FAMVIR is indicated for the treatment of recurrent episodes of orolabial or genital herpes in HIV-infected adults. The efficacy of FAMVIR when initiated more than 48 hours after onset of symptoms or lesions has not been established.

Limitation of Use

The efficacy and safety of FAMVIR have not been established for:

  • Patients <18 years of age
  • Patients with first episode of genital herpes
  • Patients with ophthalmic zoster
  • Immunocompromised patients other than for the treatment of recurrent orolabial or genital herpes in HIV-infected patients
  • Black and African American patients with recurrent genital herpes

See all Famvir indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Famvir (Famciclovir)

Evaluation of orally administered famciclovir in cats experimentally infected with feline herpesvirus type-1. [2011.01]
OBJECTIVE: To evaluate orally administered famciclovir for treatment of cats with experimentally induced disease attributable to feline herpesvirus type-1 (FHV-1)...

One-day famciclovir vs. placebo in patient-initiated episodic treatment of recurrent genital herpes in immunocompetent Black patients. [2010.03]
BACKGROUND: There are no known racial differences in genital herpes disease pathogenesis or response to therapy. Despite high herpes simplex virus (HSV) seroprevalence in Black persons, clinical trials investigating the treatment of recurrent genital herpes (RGH) have typically enrolled a small proportion of Black patients... CONCLUSION: This study showed similar efficacy and tolerability of 1-day treatment with famciclovir 1000 mg twice-daily compared to placebo in immunocompetent Black adults with RGH. Famciclovir has proven efficacy and safety in the overall RGH population. Further understanding of the efficacy of antiherpes therapy in Black patients with recurrent genital herpes may be warranted.

One-day famciclovir vs. placebo in patient-initiated episodic treatment of recurrent genital herpes in immunocompetent Black patients. [2010]
Black patients... CONCLUSION: This study showed similar efficacy and tolerability of 1-day

Single-day famciclovir for the treatment of genital herpes: follow-up results of time to next recurrence and assessment of antiviral resistance. [2009.02]
BACKGROUND: Episodic therapy of genital herpes is usually recommended for patients with infrequent symptomatic recurrences and where transmission is not a concern. While shorter courses are as effective as standard 5-day regimens, it is unknown whether abbreviated therapy has detrimental effects on natural history and the development of antiviral resistance. OBJECTIVES: To assess time to next recurrence and development of antiviral resistance in patients with recurrent genital herpes treated with either single-day famciclovir (1 g twice-daily) or 3-day valacyclovir (500 mg twice-daily)... CONCLUSION: Treatment with single-day famciclovir for recurrent genital herpes did not shorten the time to the next recurrence. Drug resistance to penciclovir continues to be a rare event in immunocompetent patients.

Pharmacokinetics and safety of penciclovir following oral administration of famciclovir to cats. [2007.11]
OBJECTIVE: To investigate penciclovir pharmacokinetics following single and multiple oral administrations of famciclovir to cats.Famciclovir dosages of 15 mg/kg administered every 8 hours to cats are unlikely to result in plasma penciclovir concentrations with activity against feline herpesvirus-1.

more studies >>

Clinical Trials Related to Famvir (Famciclovir)

Famvir for Treatment of Hearing in Unilateral Meniere's Disease [Terminated]
The specific aim of this study is to determine the efficacy of treatment with famciclovir in unilateral Meniere's Disease patients, specifically whether hearing can be improved. The investigators will determine the percentage of unilateral Meniere's Disease patients experiencing an absence of hearing fluctuation after 3 months of treatment with famciclovir as compared to the placebo arm.

Efficacy and Safety of Famciclovir 1-day Treatment Compared to 3-day Treatment With Valacyclovir in Adults With Recurrent Genital Herpes [Completed]
This study will assess the safety and efficacy of one-day famciclovir (1000 mg twice a day (b. i.d)) in reducing the duration of genital herpes lesions and the associated symptoms compared to three-day treatment with valacyclovir (500 mg capsule b. i.d).

Famciclovir Pediatric Formulation in Children 1 to 12 Years of Age With Herpes Simplex Infection [Completed]
This study will evaluate the safety and blood levels of a new pediatric formulation of Famvir in children 1-12 years of age. In Part A, patients will receive a single dose of famciclovir (12. 5 mg/kg) to assess pharmacokinetics (PK) and safety. In Part B, patients will receive multiple doses of famciclovir alone or with concomitant oral anti-herpes therapy to assess safety and tolerability. Part B will start only after PK data from Part A had been analyzed.

Pharmacokinetics, Acceptability and Safety of Famciclovir in Infants (1 Month to Less Than 12 Months) With Herpes Simplex Infection [Completed]
This study will evaluate the acceptability and safety of famciclovir in infants with herpes simplex infection

Bioequivalency Study of Famciclovir 500 mg Tablets Under Fasted Conditions [Completed]
The objective of this study was to prove the bioequivalence of Famciclovir 500 mg Tablets under fasting conditions.

more trials >>

Reports of Suspected Famvir (Famciclovir) Side Effects

Loss of Consciousness (16)Rhabdomyolysis (8)Malaise (7)Dizziness (7)Fall (6)Convulsion (5)Cerebral Infarction (5)Altered State of Consciousness (5)Asthenia (5)Blood Pressure Decreased (5)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 1 ratings/reviews, Famvir has an overall score of 6. The effectiveness score is 8 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst.
 

Famvir review by 62 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   Chronic Fatigue - Epstein Barr Virus
Dosage & duration:   500 MG taken 3 x day for the period of 3 years
Other conditions:   IBS
Other drugs taken:   Previcid
  
Reported Results
Benefits:   The flare ups of fibromyalgia seemed to subside considerably. I was able to actually get out of bed during the day. I still, however, have bouts of pain; especially if I try to reduce the amount I take during the day.
Side effects:   Occasional upset stomach, dependency on taking the drug.
Comments:   Taken as a pill three times a day.

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Page last updated: 2013-02-10

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