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Extendryl (Phenylephrine Hydrochlride / Phenylephrine Maleate / Methscopolamine Nitrate) - Warnings and Precautions

 
 



PRECAUTIONS

General:    Use cautiously, if at all, in the presence of pyloric obstruction. Use with caution in those over 40 years of age, in the presence of diabetes mellitus or urinary retention, and in men with prostatic hypertrophy or a history of bladder difficulty. If disturbances in urination occur, medication should be discontinued for 1 or 2 days and then resumed at a lower dosage. Antihistamines may cause excitability, especially in children. Information for patients: Because this product may cause blurring of vision or drowsiness, patients should be cautioned against driving or operating machinery.

Drug interactions:    MAO inhibitors and beta adrenergic blockers increase the effects of sympathomimetics. Sympathomimetics may reduce the antihypertensive effects of methyldopa, guanethidine, mecamylamine, reserpine and veratrum alkaloids. Concomitant use of antihistamines with alcohol or other CNS depressants may have an additive effect. Pregnancy: Pregnancy Category C. It is also not known whether the product can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. The product should be given to a pregnant woman only if clearly needed. Nursing mothers: It is not known whether these drugs are excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when this product is administered to a nursing woman. Pediatric use: Safety and effectiveness in children below the age of 6 have not been established.

Geriatric use:    Anticholinergic and CNS stimulant effects more likely to occur in older patients; danger of precipitating undiagnosed glaucoma; possible impairment of memory.

Page last updated: 2006-02-22

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