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Extendryl (Phenylephrine Hydrochlride / Phenylephrine Maleate / Methscopolamine Nitrate) - Description and Clinical Pharmacology

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DESCRIPTION

Each dose contains: Phenylephrine
HCl 		Chlorpheniramine
Maleate 		Methscopolamine
Nitrate
Extendryl SR Capsule 20 mg 8 mg 2.50 mg
Extendryl JR Capsule 10 mg 4 mg 1.25 mg
Extendryl Chewable Tablet
(Root beer flavored) 		10 mg 2 mg 1.25 mg
Extendryl Syrup (5 mL)
(Root beer flavored) 		10 mg 2 mg 1.25 mg

CLINICAL PHARMACOLOGY

Chlorpheniramine maleate is an alkylamine antihistamine which possesses anticholinergic and sedative effects. Phenylephrine HCl is a sympathomimetic which acts predominantly on alpha receptors and has little action on beta receptors, with a mild central stimulant effect. Methscopolamine nitrate is a derivative of scopolamine, which possesses the peripheral actions of the belladonna alkaloids, but does not exhibit the central actions because of its inability to cross the blood-brain barrier.

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