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Exforge (Amlodipine Besylate / Valsartan) - Summary

 

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USE IN PREGNANCY

When used in pregnancy, drugs that act directly on the renin-angiotensin system can cause injury and even death to the developing fetus.   When pregnancy is detected, Exforge ®  (amlodipine and valsartan) should be discontinued as soon as possible.

See WARNINGS: Fetal/Neonatal Morbidity and Mortality

 

EXFORGE SUMMARY

Exforge

Exforge® (amlodipine and valsartan) is a fixed combination of amlodipine and valsartan. Exforge® contains the besylate salt of amlodipine, a dihydropyridine calcium channel blocker (CCB). Amlodipine besylate is a white to pale yellow crystalline powder, slightly soluble in water and sparingly soluble in ethanol.

Exforge® (amlodipine and valsartan) is indicated for the treatment of hypertension.   

This fixed combination drug is not indicated for the initial therapy of hypertension (see DOSAGE AND ADMINISTRATION).

EXFORGE NEWS HIGHLIGHTS

Media Articles Related to Exforge (Amlodipine / Valsartan)

Pseudotumor Cerebri (Idiopathic Intracranial Hypertension)
Source: MedicineNet Brain Tumor Specialty [2008.09.30]

Study Finds Antioxidant Deficiency Linked To Pulmonary Hypertension
Source: Hypertension News From Medical News Today [2008.09.24]

Vitamin C Might Help Lower Hypertension
Source: MedicineNet High Blood Pressure Specialty [2008.09.22]

Using Honeybee Venom Toxin To Develop A New Tool For Studying Hypertension
Source: Hypertension News From Medical News Today [2008.09.19]

Prehypertension by Age 35 Clogs Arteries
Source: MedicineNet CAT Scan Specialty [2008.07.15]

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Published Studies Related to Exforge (Amlodipine / Valsartan)

Efficacy of the Combination of Amlodipine and Valsartan in Patients With Hypertension Uncontrolled With Previous Monotherapy: The Exforge in Failure After Single Therapy (EX-FAST) Study. [2008.03]

Effects of valsartan or amlodipine alone or in combination on plasma catecholamine levels at rest and during standing in hypertensive patients. [2007.03]

Nilotinib. [2008]

[A first drug combination for the treatment of arterial hypertension with a calcium channel antagonist (amlodipine besylate) and an angiotensin receptor blocker (valsartan): Exforge] [2007.11]

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Clinical Trials Related to Exforge (Amlodipine / Valsartan)

Long Term Study of Valsartan and Amlodipine in Patients With Essential Hypertension (Extension to Study CVAA489A1301)

Efficacy and Safety of Valsartan and Amlodipine in Patients With Essential Hypertension [Completed]

Safety and Efficacy of Valsartan and Amlodipine Combined and Alone in Patients With Hypertension. [Completed]

The Effects of Systolic Blood Pressure Lowering on Diastolic Function Using Valsartan + Amlodipine in Patients With Hypertension and Diastolic Dysfunction

One Year Study to Evaluate the Safety of the Combination of Valsartan and Amlodipine in Patients With Hypertension [Completed]

more>>

Page last updated: 2008-09-30

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