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Ethmozine (Moricizine Hydrochloride) - Drug Interactions, Contraindications, Overdosage, etc

 
 



DRUG INTERACTIONS

ETHMOZINE drug label information in our database does not contain a dedicated section on drug interactions. Please check subsections of WARNINGS AND PRECAUTIONS as well as other sources.

OVERDOSAGE

Deaths have occurred after accidental or intentional overdosages of 2,250 and 10,000 mg of Ethmozine® (moricizine hydrochloride), respectively.

Signs, Symptoms and Laboratory Findings Associated with an Overdosage of Drug

Overdosage with Ethmozine® may produce emesis, lethargy, coma, syncope, hypotension, conduction disturbances, exacerbation of congestive heart failure, myocardial infarction, sinus arrest, arrhythmias (including junctional bradycardia, ventricular tachycardia, ventricular fibrillation and asystole), and respiratory failure.

Lethal Dose in Animals

Oral doses of Ethmozine® of about 200 mg/kg in dogs, 250 mg/kg in monkeys, 420 mg/kg in mice and 905 mg/kg in rats were lethal to about one-half of the animals exposed. Death was usually preceded by tremors, convulsions and respiratory depression.

Recommended General Treatment Procedures

A specific antidote for Ethmozine® has not been identified. In the event of overdosage, treatment should be supportive. Patients should be hospitalized and monitored for cardiac, respiratory and CNS changes. Advanced life support systems, including an intracardiac pacing catheter, should be provided where necessary. Acute overdosage should be treated with appropriate gastric evacuation, and with special care to avoid aspiration. Accidental introduction of Ethmozine® into the lungs of monkeys resulted in rapid arrhythmic death.

CONTRAINDICATIONS

Ethmozine® (moricizine hydrochloride) is contraindicated in patients with pre-existing second- or third-degree AV block and in patients with right bundle branch block when associated with left hemiblock (bifascicular block) unless a pacemaker is present. Ethmozine® is also contraindicated in the presence of cardiogenic shock or known hypersensitivity to the drug.

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