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Estazolam (Estazolam) - Summary



Estazolam, a triazolobenzodiazepine derivative, is an oral hypnotic agent. Estazolam occurs as a fine, white, odorless powder that is soluble in alcohol and practically insoluble in water.

Estazolam is indicated for the short-term management of insomnia characterized by difficulty in falling asleep, frequent nocturnal awakenings, and/or early morning awakenings. Both outpatient studies and a sleep laboratory study have shown that estazolam administered at bedtime improved sleep induction and sleep maintenance (see CLINICAL PHARMACOLOGY).

Because insomnia is often transient and intermittent, the prolonged administration of estazolam is generally neither necessary nor recommended. Since insomnia may be a symptom of several other disorders, the possibility that the complaint may be related to a condition for which there is a more specific treatment should be considered.

There is evidence to support the ability of estazolam to enhance the duration and quality of sleep for intervals up to 12 weeks (see CLINICAL PHARMACOLOGY).

See all Estazolam indications & dosage >>


Media Articles Related to Estazolam

How the smartphone may help insomnia
Source: IT / Internet / E-mail News From Medical News Today [2016.05.12]
An investigation published in Psychotherapy and Psychosomatics indicates how the smartphone may have a potential in the treatment of insomnia.

ACP recommends cognitive behavioral therapy over drugs for treating chronic insomnia
Source: Sleep / Sleep Disorders / Insomnia News From Medical News Today [2016.05.03]
Cognitive behavioral therapy for insomnia (CBT-I) should be the first-line treatment for adults with chronic insomnia, according to the American College of Physicians (ACP).

Why white matter matters in insomnia
Source: MRI / PET / Ultrasound News From Medical News Today [2016.04.08]
Insomnia can strike anyone at any time, yet the neurology involved is still poorly understood. A new study examines the role of white matter in this exhausting and cryptic malady.

The High Price of Untreated Insomnia
Source: MedicineNet Sleep Aids And Stimulants Specialty [2016.03.10]
Title: The High Price of Untreated Insomnia
Category: Health News
Created: 3/10/2016 12:00:00 AM
Last Editorial Review: 3/10/2016 12:00:00 AM

Source: MedicineNet Biorhythms Specialty [2015.11.23]
Title: Insomnia
Category: Diseases and Conditions
Created: 6/6/2005 12:00:00 AM
Last Editorial Review: 11/23/2015 12:00:00 AM

more news >>

Published Studies Related to Estazolam

[Analysis on somnipathy related factors in elderly patients with stroke and comparative study on the efficacy of treatment by traditional Chinese medicine and by estazolam] [2009.03]
OBJECTIVE: To analyze the somnipathy related factors in elderly patients with stroke and to compare effects of traditional Chinese medicine and estazolam on sleep and the followed nervous function... CONCLUSION: The occurrence of somnipathy in stroke patients was closely related with the property and site of lesion, and the neurological deficit degree of patients. Better sleep is surely favorable for recovery of the nervous function, and TCM shows a favorable efficacy on somnipathy.

Comparative bioavailability of two estazolam tablet formulations in Indonesian healthy volunteers. [2008]
AIM: To compare the bioavailability of two estazolam (CAS 29975-16-4) tablet formulations (Estalin 2 mg tablets as test formulation and 2 mg tablets of the originator product as reference formulation)... CONCLUSION: These results indicate that two formulations of estazolam are bioequivalent and, thus, may be prescribed interchangeably.

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Clinical Trials Related to Estazolam

Randomised, Double-blind Study to Investigate the Safety and Efficacy of Brotizolam in Insomnia Outpatients. [Completed]
To investigate the efficacy and safety of Brotizolam in the treatment of patients with insomnia in comparison with that of Estazolam

A Study to Evaluate Efficacy and Safety of Zolpidem Modified Release Formulation in Insomnia Patients [Completed]
The purpose of the study is to investigate the efficacy and safety of zolpidem modified release (MR) tablet using estazolam (Eurodin) as a comparative drug in patients with primary insomnia.

Effects of Discontinuation of Benzodiazepine-derivative Hypnotics on Cognitive and Motor Functions in Elderly Persons [Completed]
Benzodiazepines (BZDs) have been reported to cause negative impacts on motor as well as cognitive functions, which in turn could result in lethal incidents including falls especially in the elderly. This notwithstanding, few trials have evaluated a feasibility and benefits of discontinuing BZD-derivative hypnotics in a systematic manner in this frail population. In this 8-week open-label study, we examined changes in motor and cognitive functions following the discontinuation of BZD hypnotics in older persons. OBJECTIVES & HYPOTHESES 1. Primary Objective The primary objective is to examine the feasibility of discontinuing BZD-derivative hypnotics in older people. 2. Secondary Objectives 1. One of the secondary objectives is to examine the magnitude of discontinuing BZD-derivative hypnotics in the stability of body. 2. Another secondary objective is to examine the magnitude of discontinuing BZD-derivative hypnotics in cognitive function. Hypotheses 1. More than 80% of the participants will complete and tolerate all the study procedures. 2a. Participants will show an improvement in the stability of body. 2b. Participants will show an improvement in the cognitive function globally as well as specifically in attention.

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Reports of Suspected Estazolam Side Effects

Disseminated Intravascular Coagulation (21)Disease Progression (16)Hepatitis Acute (16)Condition Aggravated (16)Atrial Fibrillation (16)Concomitant Disease Progression (16)Circulatory Collapse (14)Serotonin Syndrome (13)Cardiac Failure Congestive (12)Hyponatraemia (10)more >>

Page last updated: 2016-05-12

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