Estazolam, a triazolobenzodiazepine derivative, is an oral hypnotic agent. Estazolam occurs as a fine, white, odorless powder that is soluble in alcohol and practically insoluble in water.
Estazolam is indicated for the short-term management of insomnia characterized by difficulty in falling asleep, frequent nocturnal awakenings, and/or early morning awakenings. Both outpatient studies and a sleep laboratory study have shown that estazolam administered at bedtime improved sleep induction and sleep maintenance (see CLINICAL PHARMACOLOGY).
Because insomnia is often transient and intermittent, the prolonged administration of estazolam is generally neither necessary nor recommended. Since insomnia may be a symptom of several other disorders, the possibility that the complaint may be related to a condition for which there is a more specific treatment should be considered.
There is evidence to support the ability of estazolam to enhance the duration and quality of sleep for intervals up to 12 weeks (see CLINICAL PHARMACOLOGY).
Media Articles Related to Estazolam
Insomnia leads to decreased empathy in health care workers
Source: Caregivers / Homecare News From Medical News Today [2015.06.10]
Study highlights the importance to evaluate and treat insomnia in health care workersA new study suggests that insomnia decreases empathy in health care workers and may lead to adverse clinical...
73% of insomniacs cured after 1-hour therapy session
Source: Complementary Medicine / Alternative Medicine News From Medical News Today [2015.06.02]
A simple one-hour therapy session has helped to cure 73% of people suffering from acute insomnia, according to a new study from Northumbria University.
Source: MedicineNet Creutzfeldt-Jakob Disease Specialty [2014.07.17]
Category: Diseases and Conditions
Created: 6/6/2005 12:00:00 AM
Last Editorial Review: 7/17/2014 12:00:00 AM
Twitter data may help shed light on sleep disorders
Source: Sleep / Sleep Disorders / Insomnia News From Medical News Today [2015.06.12]
Researchers generate a 'digital phenotype' of Twitter users with sleep problemsResearchers from Boston Children's Hospital and Merck have built the beginnings of "digital phenotype" of insomnia...
Published Studies Related to Estazolam
[Analysis on somnipathy related factors in elderly patients with stroke and comparative study on the efficacy of treatment by traditional Chinese medicine and by estazolam] [2009.03]
OBJECTIVE: To analyze the somnipathy related factors in elderly patients with stroke and to compare effects of traditional Chinese medicine and estazolam on sleep and the followed nervous function... CONCLUSION: The occurrence of somnipathy in stroke patients was closely related with the property and site of lesion, and the neurological deficit degree of patients. Better sleep is surely favorable for recovery of the nervous function, and TCM shows a favorable efficacy on somnipathy.
Comparative bioavailability of two estazolam tablet formulations in Indonesian healthy volunteers. 
AIM: To compare the bioavailability of two estazolam (CAS 29975-16-4) tablet formulations (Estalin 2 mg tablets as test formulation and 2 mg tablets of the originator product as reference formulation)... CONCLUSION: These results indicate that two formulations of estazolam are bioequivalent and, thus, may be prescribed interchangeably.
Clinical Trials Related to Estazolam
Randomised, Double-Blind Study to Investigate the Safety and Efficacy of Brotizolam in Insomnia Outpatients. [Completed]
To investigate the efficacy and safety of Brotizolam in the treatment of patients with
insomnia in comparison with that of Estazolam
A Study to Evaluate Efficacy and Safety of Zolpidem Modified Release Formulation in Insomnia Patients [Recruiting]
The purpose of the study is to investigate the efficacy and safety of zolpidem modified
release (MR) tablet using estazolam (Eurodin) as a comparative drug in patients with primary
Reports of Suspected Estazolam Side Effects
Disseminated Intravascular Coagulation (21),
Disease Progression (16),
Hepatitis Acute (16),
Condition Aggravated (16),
Atrial Fibrillation (16),
Concomitant Disease Progression (16),
Circulatory Collapse (14),
Serotonin Syndrome (13),
Cardiac Failure Congestive (12),
Hyponatraemia (10), more >>
Page last updated: 2015-06-12