Esidrix (Hydrochlorothiazide) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

Adverse reactions are usually reversible upon reduction of dosage or discontinuation of Esidrix. Whenever adverse reactions are moderate or severe, it may be necessary to discontinue the drug.

      The following adverse reactions have been observed, but there has not been enough systematic collection of data to support an estimate of their frequency. Consequently the reactions are categorized by organ systems and are listed in decreasing order of severity and not frequency.

      Digestive: Pancreatitis, jaundice (intrahepatic cholestatic), sialadenitis, vomiting, diarrhea, cramping, nausea, gastric irritation, constipation, anorexia.

      Cardiovascular: Orthostatic hypotension (may be potentiated by alcohol, barbiturates, or narcotics).

      Neurologic: Vertigo, dizziness, transient blurred vision, headache, paresthesia, xanthopsia, weakness, restlessness.

      Musculoskeletal: Muscle spasm.

      Hematologic: Aplastic anemia, agranulocytosis, leukopenia, thrombocytopenia.

      Metabolic: Hyperglycemia, glycosuria, hyperuricemia.

      Hypersensitive Reactions: Necrotizing angiitis, Stevens- Johnson syndrome, respiratory distress including pneumonitis and pulmonary edema, purpura, urticaria, rash, photosensitivity.

REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO ESIDRIX

Possible Esidrix side effects / adverse reactions in 43 year old female

Reported by a physician from Germany on 2007-01-19

Patient: 43 year old female weighing 75.0 kg (165.0 pounds)

Reactions: Renal Impairment, Fatigue, Renal Failure, Diarrhoea, Nausea, Oedema Peripheral, Drug Interaction, Immunosuppressant Drug Level Increased, Blood Creatinine Increased

Adverse event resulted in: hospitalization

Suspect drug(s):
Enalapril Maleate

Esidrix

Certican
    Dosage: 0.75 mg, bid
    Indication: Lung Transplant
    Start date: 2005-04-19

Certican
    Dosage: 0.125 mg

Neoral
    Dosage: 100 mg, bid
    Indication: Lung Transplant

Neoral
    Dosage: 30 mg, bid

Neoral
    Dosage: 25 mg

Cotrim
    Start date: 2005-03-23

Other drugs received by patient possibly interacting with the suspect drug:
Sempera
    Start date: 2005-03-21

Ciprofloxacin

Other drugs received by patient: Decortin-H

Possible Esidrix side effects / adverse reactions in 86 year old male

Reported by a individual with unspecified qualification from France on 2007-02-09

Patient: 86 year old male

Reactions: Vomiting, Ileus, Blood Creatinine Increased, Constipation, Hypokalaemia, Renal Failure Acute

Adverse event resulted in: hospitalization

Suspect drug(s):
Burinex
    Dosage: 10 mg/day
    Administration route: Oral
    Start date: 2005-01-01
    End date: 2006-11-17

Esidrix
    Dosage: 25 mg, qd
    Administration route: Oral
    Indication: Hypertension
    Start date: 2006-08-10
    End date: 2006-11-17

Other drugs received by patient: Mono-Tildiem; Hyperium

Possible Esidrix side effects / adverse reactions in 82 year old male

Reported by a individual with unspecified qualification from France on 2007-02-09

Patient: 82 year old male

Reactions: White Blood Cell Count Decreased, Gastrointestinal Haemorrhage, Anaemia, Pancytopenia, Purpura, Diverticulum Intestinal, Liver Disorder, Gastritis, Pancreatic Disorder, RED Blood Cell Count Decreased, Platelet Count Decreased

Adverse event resulted in: hospitalization

Suspect drug(s):
Voltaren
    Administration route: Oral

Esidrix
    Dosage: 25 mg, qd
    Administration route: Oral

Fucidine CAP
    Dosage: 500 mg, bid
    Administration route: Oral
    Indication: Varicose Ulceration
    Start date: 2006-10-08
    End date: 2006-10-25

Flammazine
    Administration route: Topical

Triatec
    Dosage: 5 mg, qd
    Administration route: Oral

Other drugs received by patient: Virlix; Biafine; Doliprane