Eryc (Erythromycin) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

The most frequent side effects of oral erythromycin preparations are gastrointestinal and are dose-related. They include nausea, vomiting, abdominal pain, diarrhea and anorexia. Onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment. (See WARNINGS). Symptoms of hepatic dysfunction and/or abnormal liver function test results may occur (See WARNINGS).

Rarely, erythromycin has been associated with the production of ventricular arrhythmias, including ventricular tachycardia and torsade de pointes, in individuals with prolonged QTc intervals.

Allergic reactions ranging from urticaria to anaphylaxis have occurred. Skin reactions ranging from mild eruptions to erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis have been reported rarely.

REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO ERYC

Possible Eryc side effects / adverse reactions in 83 year old male

Reported by a physician from Norway on 2007-06-11

Patient: 83 year old male weighing 102.0 kg (224.4 pounds)

Reactions: Weight Decreased, Bedridden, Respiratory Disorder, Creatinine Renal Clearance Decreased, Rhabdomyolysis

Adverse event resulted in: hospitalization

Suspect drug(s):
Eryc
    Dosage: 500 mg, qid, oral
    Administration route: Oral
    Indication: Pneumonia Primary Atypical

Erythromycin
    Dosage: 500 mg, qid, intravenous
    Indication: Pneumonia Primary Atypical

Simvastatin
    Dosage: 80 mg, qd

Other drugs received by patient: Metoprolol Tartrate; Amlodipine; Hydrochlorothiazide W/valsartan (Hydrochlorothiazixe, Valsartan); Aspirin; Methotrexate; Furosemide

Possible Eryc side effects / adverse reactions in 65 year old male

Reported by a physician from United States on 2007-06-20

Patient: 65 year old male

Reactions: Rhabdomyolysis, Drug Level Increased, Drug Interaction

Adverse event resulted in: hospitalization

Suspect drug(s):
Eryc
    Dosage: oral
    Administration route: Oral
    Indication: Pneumonia

Lovastatin
    Dosage: 20 mg, tid, oral
    Administration route: Oral
    Indication: Blood Cholesterol Increased

Other drugs received by patient: Aspirin

Possible Eryc side effects / adverse reactions in 68 year old female

Reported by a physician from United States on 2007-06-25

Patient: 68 year old female

Reactions: Rhabdomyolysis, Blood Phosphorus Increased, Drug Interaction, Pyrexia, Idiopathic Pulmonary Fibrosis, Muscle Necrosis, Renal Failure, Ventricular Dysfunction, Mitral Valve Incompetence, Pulmonary Oedema, Aldolase Increased

Adverse event resulted in: death, hospitalization

Suspect drug(s):
Eryc

Lovastatin
    Dosage: 20 mg, bid
    Indication: Hypercholesterolaemia

Other drugs received by patient: Ampicillin Sodium W/sulbactam Sodium (Ampicillin Sodium, Sulbactam SOD; Amoxiclav /01000301/ (Amoxicillin, Clavulanate Potassium); Furosemide; Sucralfate; Ranitidine; Allopurinol; Insulin (Insulin); Isosorbide (Isosorbide); Enalapril (Enalapril); Digoxin; Prednisone TAB