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Epiquin (Hydroquinone / Retinol) - Description and Clinical Pharmacology

 
 



DESCRIPTION

EpiQuin™ Micro and EpiQuin™ Micro XD contain hydroquinone USP 4% and retinol (vitamin A) incorporated into patented porous microspheres (Microsponge® * System) composed of methyl methacrylate/glycol dimethacrylate crosspolymer. This polymeric system has been shown to provide gradual release of active ingredient into the skin.1Hydroquinone is 1,4-benzenediol. Hydroquinone is structurally related to monobenzone. Hydroquinone occurs as fine, white needles. The drug is freely soluble in water and in alcohol and has a pKa of 9.96. Chemically, hydroquinone is designated as p-dihydroxybenzene; the empirical formula is C6H6O2; molecular weight 110.1. The structural formula is:

ACTIVE INGREDIENT:

Hydroquinone USP, 4%

OTHER INGREDIENTS:

Water, Caprylic/Capric Triglyceride, Emulsifying Wax, Dimethicone, Glycerin, C10-30 Cholesterol/Lanosterol Esters, Cetyl Alcohol, Cetyl Ricinoleate, Methyl Methacrylate/Glycol Dimethacrylate Crosspolymer, Retinol (Vitamin A), Tocopheryl Acetate (Vitamin E), Ascorbic Acid (Vitamin C), Ascorbyl Palmitate, Bisabolol, Cyclomethicone, PEG-10 Soy Sterol, Polyacrylamide, C13-14 Isoparaffin, Laureth-7, Magnesium Aluminum Silicate, TEA-Stearate, Cetyl Phosphate, Butylated Hydroxy Toluene, Propyl Gallate, Disodium EDTA, Benzyl Alcohol, Methylparaben, Phenoxyethanol, Polysorbate 20, Triethanolamine, Sodium Metabisulfite.

CLINICAL PHARMACOLOGY

Topical application of hydroquinone produces a reversible depigmentation of the skin by inhibition of the enzymatic oxidation of tyrosine to 3-(3,4-dihydroxyphenyl)alanine (dopa)2 and suppression of other melanocyte metabolic processes. 3 Exposure to sunlight or ultraviolet light will cause repigmentation of the bleached areas. 4

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