EPIPEN®
Auto-Injector for Intramuscular Injection of Epinephrine
PRESCRIBING INFORMATION
(PHARMACIST - PLEASE REMOVE BEFORE DISPENSING)
EPIPEN® 0.3 mg EPINEPHRINE AUTO-INJECTOR
Auto-Injector for Intramuscular Injection of Epinephrine
For the Emergency Treatment of Allergic Reactions (Anaphylaxis)
Delivers a single 0.3 mg intramuscular dose of epinephrine from epinephrine injection, USP, 1:1000 (0.3 mL).
EPIPEN® JR 0.15 mg EPINEPHRINE AUTO-INJECTOR
Auto-Injector for Intramuscular Injection of Epinephrine
For the Emergency Treatment of Allergic Reactions (Anaphylaxis)
Delivers a single 0.15 mg intramuscular dose of epinephrine from epinephrine injection, USP, 1:2000 (0.3 mL).
IMPORTANT INFORMATION
- DO NOT REMOVE GRAY SAFETY RELEASE UNTIL READY FOR USE.
- A SINGLE DOSE OF 0.3 ML OF SOLUTION IS DISPENSED. THE MAJORITY OF THE DRUG PRODUCT, 1.7 ML, REMAINS IN THE AUTO-INJECTOR AFTER ACTIVATION AND CANNOT BE USED.
- THE UNIT CONTAINS NO LATEX.
DESCRIPTION
The EpiPen® and Epipen® Jr auto-injectors contain 2 mL epinephrine injection for emergency intramuscular use. Each EpiPen auto-injector delivers a single dose of 0.3 mg epinephrine from epinephrine injection, USP, 1:1000 (0.3 mL) in a sterile solution.
Each EpiPen Jr auto-injector delivers a single dose of 0.15 mg epinephrine from epinephrine injection, USP, 1:2000 (0.3 mL) in a sterile solution.
For stability purposes, approximately 1.7 mL remains in the auto-injector after activation and cannot be used.
Each 0.3 mL in EpiPen contains 0.3 mg epinephrine, 1.8 mg sodium chloride, 0.5 mg sodium metabisulfite, hydrochloric acid to adjust pH, and Water for Injection. The pH range is 2.2-5.0. Each 0.3 mL in EpiPen Jr contains 0.15 mg epinephrine, 1.8 mg sodium chloride, 0.5 mg sodium metabisulfite, hydrochloric acid to adjust pH, and Water for Injection. The pH range is 2.2-5.0.
Epinephrine is a sympathomimetic catecholamine. Chemically, epinephrine is B-(3, 4-dihydroxyphenyl)-a-methyl-aminoethanol, with the following structure:
It deteriorates rapidly on exposure to air or light, turning pink from oxidation to adrenochrome and brown from the formation of melanin. Epinephrine solutions which show evidence of discoloration should be replaced.
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