Epipen (Epinephrine Injection) - Summary

EPIPEN SUMMARY

EPIPEN^®
Auto-Injector for Intramuscular Injection of Epinephrine

The EpiPen® and Epipen® Jr auto-injectors contain 2 mL epinephrine injection for emergency intramuscular use. Each EpiPen® auto-injector delivers a single dose of 0.3 mg epinephrine from epinephrine injection, USP, 1:1000 (0.3 mL) in a sterile solution.

Epinephrine is indicated in the emergency treatment of allergic reactions (anaphylaxis) to insect stings or bites, foods, drugs and other allergens as well as idiopathic or exercise-induced anaphylaxis. The EpiPen® and EpiPen® Jr auto-injectors are intended for immediate self-administration by a person with a history of an anaphylactic reaction. Such reactions may occur within minutes after exposure and consist of flushing, apprehension, syncope, tachycardia, thready or unobtainable pulse associated with a fall in blood pressure, convulsions, vomiting, diarrhea and abdominal cramps, involuntary voiding, wheezing, dyspnea due to laryngeal spasm, pruritis, rashes, uticaria or angioedema. The EpiPen® and EpiPen® Jr are designed as emergency supportive therapy only and are not a replacement or substitute for immediate medical or hospital care.

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NEWS HIGHLIGHTS

Media Articles Related to Epipen (Epinephrine Injection)

Aterica develops world's first high-tech smart case for EpiPen to help families living with anaphylaxis
Source: Allergy News From Medical News Today [2015.01.09]
Aterica, a digital health company, announces Veta™, the world's first anaphylaxis and food allergy support system for individuals and their families.

Anaphylaxis
Source: MedicineNet Allergic Cascade Specialty [2015.02.20]
Title: Anaphylaxis
Category: Diseases and Conditions
Created: 4/15/2000 12:00:00 AM
Last Editorial Review: 2/20/2015 12:00:00 AM

Intranasal Flu Vaccine Appears Safe for Egg-Allergic Kids
Source: Medscape Allergy & Clinical Immunology Headlines [2015.02.23]
Children with a history of allergic reactions or anaphylaxis after egg exposure safely tolerated the live attenuated vaccine.
Medscape Medical News

UK trainee doctors still in the dark about potentially fatal allergic reaction
Source: Allergy News From Medical News Today [2015.01.13]
UK trainee doctors on the frontline of care seem to be no better at recognising and treating the potentially fatal allergic reaction, known as anaphylaxis, than they were 10 years ago, reveals a...

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Published Studies Related to Epipen (Epinephrine Injection)

Faster onset and more comfortable injection with alkalinized 2% lidocaine with epinephrine 1:100,000. [2013]
(IANBs)... CONCLUSIONS: Alkalinizing lidocaine with epinephrine toward physiologic pH

A comparison of the efficacy of 4% articaine with 1:100,000 epinephrine and 2% lidocaine with 1:80,000 epinephrine in achieving pulpal anesthesia in maxillary teeth with irreversible pulpitis. [2012]
anesthesia in maxillary teeth with irreversible pulpitis... CONCLUSIONS: There was no significant difference in efficacy between 4% articaine

Effect of intravenous lidocaine associated with amitriptyline on pain relief and plasma serotonin, norepinephrine, and dopamine concentrations in fibromyalgia. [2011.05]
OBJECTIVE: The objective of this study was to evaluate the effect of intravenous lidocaine combined with amitriptyline on pain relief and plasma serotonin, norepinephrine, and dopamine levels... CONCLUSIONS: Combined administration of 240 mg intravenous lidocaine (once a week) and 25 mg amitriptyline for 4 weeks did not modify pain intensity or plasma serotonin, norepinephrine, or dopamine concentrations in fibromyalgia patients.

Anesthetic efficacy of 4% Articaine with 1:100,000 epinephrine versus 4% articaine with 1:200,000 epinephrine as a primary buccal infiltration in the mandibular first molar. [2011.04]
INTRODUCTION: No study has compared 4% articaine with 1:100,000 epinephrine with 4% articaine with 1:200,000 epinephrine in a mandibular buccal infiltration of the first molar. The authors conducted a prospective, randomized, double-blind, crossover study comparing the degree of pulpal anesthesia obtained with 4% articaine with 1:100,000 epinephrine and 4% articaine with 1:200,000 epinephrine as a primary infiltration in the mandibular first molar... CONCLUSIONS: The anesthetic efficacy of 4% articaine with 1:200,000 epinephrine is comparable to 4% articaine with 1:100,000 epinephrine in a primary mandibular buccal infiltration of the first molar. Copyright (c) 2011 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

Does preincisional injection of levobupivacaine with epinephrine have any benefits for children undergoing tonsillectomy? An intraindividual evaluation. [2010.10]
OBJECTIVE: To evaluate the effects of peritonsillar injection of levobupivacaine with epinephrine in children undergoing adenotonsillectomy, through an intraindividual study... CONCLUSION: Preincisional injection of levobupivacaine with epinephrine decreases early postoperative pain and intraoperative blood loss as well. Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.

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Clinical Trials Related to Epipen (Epinephrine Injection)

Vasopressin and Epinephrine Versus Epinephrine Alone in Cardiac Arrest [Completed]
Recent studies have suggested that arginine-vasopressin could be more effective in the treatment of cardiac arrests. The last published study did not outline obvious improvements in the prognosis of all cardiac arrests but pointed out a possible increased survival rate when arginine-vasopressin is associated with epinephrine. The aim of this study is to compare the efficacy of two successive injections of epinephrine (1 mg) with two successive injections of epinephrine associated with arginine-vasopressin (40 UI) in out-of-hospital cardiac arrests occurring in adult patients. The primary endpoint is the survival rate at hospital admission. The inclusion period lasts 18 months and 2416 patients are planned to be enrolled.

Changes in Adrenal Hormones During Adrenal Radiofrequency Ablation [Recruiting]

Epinephrine Inhalation Aerosol USP, a HFA-MDI Study for Assessment of Pharmacokinetics [Recruiting]
This study examines the pharmacokinetic profile of Armstrong's proposed Epinephrine Inhalation Aerosol USP, an HFA-MDI (E004), using a stable isotope deuterium-labeled epinephrine (epinephrine-d3) to differentiate the administered drug from the endogenous epinephrine, in healthy male and female adult volunteers. The current study is designed for a more thorough evaluation of the E004 Pharmacokinetics. Safety of E004 will also be evaluated, under augmented dose conditions.

Epinephrine Inhalation Aerosol USP: For Evaluation Of Efficacy And Safety In Asthma Patients [Recruiting]
This clinical study evaluates the 12-week efficacy and safety of Epinephrine HFA Inhalation Aerosol HFA the proposed HFA formulation of metered dose inhaler (MDI) of Epinephrine, in comparison to a Placebo-HFA control MDI and the currently marketed Primatene® Mist (epinephrine CFC inhaler), in adolescent and adult subjects with asthma.

Test Predicting Adrenal Insufficiency in Volunteers Under Prednisone Treatment [Recruiting]
Suppression of the adrenal function is a common, potentially dangerous and unpredictable consequence of short term high dose glucocorticoid treatment. Identification of patients at risk would be of high clinical importance. The investigators hypothesized that the dexamethasone-suppression-test predicts the subsequent development of corticosteroid induced adrenal insufficiency.

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Reports of Suspected Epipen (Epinephrine Injection) Side Effects

Accidental Exposure (131),  Drug Ineffective (51),  Injury Associated With Device (44),  Expired Drug Administered (40),  Injection Site Pain (23),  Hypoaesthesia (19),  Pain in Extremity (16),  Contusion (13),  Injection Site Pallor (13),  Heart Rate Increased (13), more >>