Auto-Injector for Intramuscular Injection of Epinephrine
The EpiPen® and Epipen® Jr auto-injectors contain 2 mL epinephrine injection for emergency intramuscular use. Each EpiPen® auto-injector delivers a single dose of 0.3 mg epinephrine from epinephrine injection, USP, 1:1000 (0.3 mL) in a sterile solution.
Epinephrine is indicated in the emergency treatment of allergic reactions (anaphylaxis) to insect stings or bites, foods, drugs and other allergens as well as idiopathic or exercise-induced anaphylaxis. The EpiPen® and EpiPen® Jr auto-injectors are intended for immediate self-administration by a person with a history of an anaphylactic reaction. Such reactions may occur within minutes after exposure and consist of flushing, apprehension, syncope, tachycardia, thready or unobtainable pulse associated with a fall in blood pressure, convulsions, vomiting, diarrhea and abdominal cramps, involuntary voiding, wheezing, dyspnea due to laryngeal spasm, pruritis, rashes, uticaria or angioedema. The EpiPen® and EpiPen® Jr are designed as emergency supportive therapy only and are not a replacement or substitute for immediate medical or hospital care.
Media Articles Related to Epipen (Epinephrine Injection)
Source: MedicineNet Allergic Cascade Specialty [2015.06.24]
Category: Diseases and Conditions
Created: 4/15/2000 12:00:00 AM
Last Editorial Review: 6/24/2015 12:00:00 AM
Study shows second severe allergic reaction can occur hours after first
Source: Allergy News From Medical News Today [2015.07.08]
Affects almost 15 percent of kidsParents of kids with severe allergies know how scary a severe allergic reaction (anaphylaxis) is.
Emergency visits for childhood food allergy on rise in Illinois
Source: Allergy News From Medical News Today [2015.06.26]
Visits for anaphylaxis climb 29 percent, Hispanic children's visits up 44 percent Food allergies now impacting children of all races and incomes Hispanic children have highest rise...
Published Studies Related to Epipen (Epinephrine Injection)
Faster onset and more comfortable injection with alkalinized 2% lidocaine with
epinephrine 1:100,000. 
(IANBs)... CONCLUSIONS: Alkalinizing lidocaine with epinephrine toward physiologic pH
A comparison of the efficacy of 4% articaine with 1:100,000 epinephrine and 2%
lidocaine with 1:80,000 epinephrine in achieving pulpal anesthesia in maxillary
teeth with irreversible pulpitis. 
anesthesia in maxillary teeth with irreversible pulpitis... CONCLUSIONS: There was no significant difference in efficacy between 4% articaine
Effect of intravenous lidocaine associated with amitriptyline on pain relief and plasma serotonin, norepinephrine, and dopamine concentrations in fibromyalgia. [2011.05]
OBJECTIVE: The objective of this study was to evaluate the effect of intravenous lidocaine combined with amitriptyline on pain relief and plasma serotonin, norepinephrine, and dopamine levels... CONCLUSIONS: Combined administration of 240 mg intravenous lidocaine (once a week) and 25 mg amitriptyline for 4 weeks did not modify pain intensity or plasma serotonin, norepinephrine, or dopamine concentrations in fibromyalgia patients.
Anesthetic efficacy of 4% Articaine with 1:100,000 epinephrine versus 4% articaine with 1:200,000 epinephrine as a primary buccal infiltration in the mandibular first molar. [2011.04]
INTRODUCTION: No study has compared 4% articaine with 1:100,000 epinephrine with 4% articaine with 1:200,000 epinephrine in a mandibular buccal infiltration of the first molar. The authors conducted a prospective, randomized, double-blind, crossover study comparing the degree of pulpal anesthesia obtained with 4% articaine with 1:100,000 epinephrine and 4% articaine with 1:200,000 epinephrine as a primary infiltration in the mandibular first molar... CONCLUSIONS: The anesthetic efficacy of 4% articaine with 1:200,000 epinephrine is comparable to 4% articaine with 1:100,000 epinephrine in a primary mandibular buccal infiltration of the first molar. Copyright (c) 2011 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
Does preincisional injection of levobupivacaine with epinephrine have any benefits for children undergoing tonsillectomy? An intraindividual evaluation. [2010.10]
OBJECTIVE: To evaluate the effects of peritonsillar injection of levobupivacaine with epinephrine in children undergoing adenotonsillectomy, through an intraindividual study... CONCLUSION: Preincisional injection of levobupivacaine with epinephrine decreases early postoperative pain and intraoperative blood loss as well. Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
Clinical Trials Related to Epipen (Epinephrine Injection)
Vasopressin and Epinephrine Versus Epinephrine Alone in Cardiac Arrest [Completed]
Recent studies have suggested that arginine-vasopressin could be more effective in the
treatment of cardiac arrests. The last published study did not outline obvious improvements
in the prognosis of all cardiac arrests but pointed out a possible increased survival rate
when arginine-vasopressin is associated with epinephrine. The aim of this study is to compare
the efficacy of two successive injections of epinephrine (1 mg) with two successive
injections of epinephrine associated with arginine-vasopressin (40 UI) in out-of-hospital
cardiac arrests occurring in adult patients. The primary endpoint is the survival rate at
hospital admission. The inclusion period lasts 18 months and 2416 patients are planned to be
Changes in Adrenal Hormones During Adrenal Radiofrequency Ablation [Recruiting]
Epinephrine Inhalation Aerosol USP, a HFA-MDI Study for Assessment of Pharmacokinetics [Recruiting]
This study examines the pharmacokinetic profile of Armstrong's proposed Epinephrine
Inhalation Aerosol USP, an HFA-MDI (E004), using a stable isotope deuterium-labeled
epinephrine (epinephrine-d3) to differentiate the administered drug from the endogenous
epinephrine, in healthy male and female adult volunteers. The current study is designed for
a more thorough evaluation of the E004 Pharmacokinetics. Safety of E004 will also be
evaluated, under augmented dose conditions.
Epinephrine Inhalation Aerosol USP: For Evaluation Of Efficacy And Safety In Asthma Patients [Recruiting]
This clinical study evaluates the 12-week efficacy and safety of Epinephrine HFA Inhalation
Aerosol HFA the proposed HFA formulation of metered dose inhaler (MDI) of Epinephrine, in
comparison to a Placebo-HFA control MDI and the currently marketed Primatene® Mist
(epinephrine CFC inhaler), in adolescent and adult subjects with asthma.
Test Predicting Adrenal Insufficiency in Volunteers Under Prednisone Treatment [Recruiting]
Suppression of the adrenal function is a common, potentially dangerous and unpredictable
consequence of short term high dose glucocorticoid treatment. Identification of patients at
risk would be of high clinical importance. The investigators hypothesized that the
dexamethasone-suppression-test predicts the subsequent development of corticosteroid induced
Reports of Suspected Epipen (Epinephrine Injection) Side Effects
Accidental Exposure (131),
Drug Ineffective (51),
Injury Associated With Device (44),
Expired Drug Administered (40),
Injection Site Pain (23),
Pain in Extremity (16),
Injection Site Pallor (13),
Heart Rate Increased (13), more >>
Page last updated: 2015-07-08