NEWS HIGHLIGHTS
Published Studies Related to Epifoam (Hydrocortisone / Pramoxine)
Efficacy of hydrocortisone acetate/hyaluronidase vs triamcinolone acetonide/hyaluronidase in the treatment of oral submucous fibrosis. [2010.05]
BACKGROUND & OBJECTIVES: Oral submucous fibrosis is a common premalignant condition caused by chewing arecanut and other irritants in various forms. Its medical treatment is not yet fully standardized, although the optimal doses of its medical treatment is in the form of hydrocortisone acetate combined with hyaluronidase. The problem with the prevailing treatment was injections at weekly interval. In this study we compared the efficacy of hydrocortisone acetate and hyaluronidase at weekly interval versus triamcinolone acetonide and hyaluronidase at 15 days interval... CONCLUSION: Treatment regimen of group B was more convenient to the patients because less number of visits required and cheap. No side effects were seen. A follow up study is required to see long term effects.
Topical treatment of acute otitis externa: clinical comparison of an antibiotics ointment alone or in combination with hydrocortisone acetate. [2007.09]
The study was designed to investigate the potential contribution of hydrocortisone acetate to the efficacy and safety of an antibiotics ointment in the treatment of acute otitis externa (AOE). In a double-blind study 151 patients with a unilateral acute bacterial otitis externa were randomized either to receive an ointment with polymyxin-B sulfate (7,500 I.E./g) + bacitracin (300 I.E./g) alone (AB) or the same antibiotic ointment with 10 mg hydrocortisone acetate/g ointment (AB + HC)...
'Empty sella syndrome': a case of a patient with sodium succinate hydrocortisone allergy. [2011.01]
OBJECTIVE: We present the case of a woman with 'empty sella syndrome' who experienced generalized urticaria after the administration of sodium succinate hydrocortisone in two episodes... CONCLUSIONS: Patients with succinate ester allergy can tolerate alternative corticosteroids without ester.
Optimization and validation of an RP-HPLC method for analysis of hydrocortisone acetate and lidocaine in suppositories. [2010.01]
An RP-HPLC method has been optimized and validated for the simultaneous determination of hydrocortisone acetate and of lidocaine in suppositories. For the method optimization, response surface methodology was applied, and the obtained model was tested using analysis of variance... The method was validated for selectivity, linearity, precision, and robustness.
Efficacy of hydrocortisone acetate/hyaluronidase vs triamcinolone
acetonide/hyaluronidase in the treatment of oral submucous fibrosis. [2010]
at 15 days interval... CONCLUSION: Treatment regimen of group B was more convenient
Clinical Trials Related to Epifoam (Hydrocortisone / Pramoxine)
Contribution of Salivary Cortisol in the Detection of Infra-clinic Cortisol Adenoma (ACIC) [Recruiting]
Pharmacokinetics of Hydrocortisone After Subcutaneous Administration in Chronic Adrenal Insufficiency [Not yet recruiting]
Patients with chronic adrenal insufficiency need to adapt their hydrocortisone replacement
dose in conditions of physical or psychological stress to prevent life threatening adrenal
crisis. In cases of more severe impairment or unsecure gastrointestinal absorption (e. g.
gastroenteritis, severe infectious disease), parenteral administration of the hydrocortisone
dose is crucial. The study is conducted to offer patients the possibility to perform
hydrocortisone self administration in emergency situations in a way of administration which
is easy to perform and accepted by the patient. Therefore, pharmacokinetics and safety of
subcutaneous hydrocortisone administration will be studied and compared to intramuscular
administration.
Sensitivity of Short and Long Allele Carriers of the 5-HTTLPR to Environmental Threat Post Hydrocortisone Administration [Recruiting]
The current study will test the causal relationship between elevated levels of cortisol and
the serotonin transporter gene (5-HTTLPR) as these factors influence sensitivity to
environmental threat. The investigators predict that carriers of the short allele of the
serotonin transporter gene who have elevated cortisol levels will be most sensitive to
threatening environments, whereas carriers of the long allele who do not have elevated
cortisol (placebo subjects) will be least sensitive.
Trial of Hydrocortisone for Post-Traumatic Stress Disorder (PTSD) [Recruiting]
Developing novel and effective pharmacologic interventions for this post-traumatic stress
disorder is important. The investigators propose to replicate findings of an earlier
published pilot study using low dose hydrocortisone as a treatment for PTSD. In order to do
so in a more meaningful way, the investigators will conduct a larger but similar randomized
double-blind placebo-controlled, cross-over design treatment study examining the use of low
dose hydrocortisone (or placebo) for 4 weeks in combat veterans suffering from PTSD.
The investigators hypothesize that, as described by Aerni et al. (2004), administration of
daily hydrocortisone will lead to a reduction in PTSD symptom severity, but particularly for
re-experiencing types (e. g., flashbacks, nightmares)of symptoms. The investigators also hope
to examine potential predictors and moderators of treatment response based on subjects'
clinical characteristics, as well as serum cortisol and ACTH levels.
Hydrocortisone Replacement in Patients With Secondary Adrenal Insufficiency (SUPREME CORT) [Recruiting]
The aim of this study is to investigate whether a physiologically low hydrocortisone (HC)
dose is better for cognition as compared to a physiologically high HC dose. In addition,
quality of life, metabolic profile and somatosensation will be described in relation to HC
dose.
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