DOSAGE AND ADMINISTRATION
Depending on the clinical circumstances, Ephedrine Sulfate Injection may be given subcutaneously, intramuscularly or intravenously.
Usual adult dose: 25 to 50 mg (range 10 to 50 mg) injected subcutaneously or intramuscularly (equivalent to 0.2 to 1.0 mL of 5% solution) is usually adequate to prevent or minimize hypotension secondary to spinal anesthesia. Repeat doses should be governed by blood pressure response or, if used as a bronchodilator, according to the degree of improvement. Absorption (onset of action) by the intramuscular route is more rapid (within 10 to 20 minutes) than by subcutaneous injection. The intravenous route may be used if an immediate effect is desired.
When used during labor, administer only sufficient dosage to maintain blood pressure at or below 130/80.
In acute attacks of asthma, the smallest effective dose should be used (usually 0.25 to 0.5 mL) or as otherwise determined by the patient's response.
Usual pediatric dose: 750 micrograms per kg of body weight or 25 mg/M2 of body surface injected intravenously or subcutaneously, four times daily or as otherwise determined by the patient's response.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. See PRECAUTIONS.
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