Published Studies Related to Eovist (Gadoxetic Acid)
Evaluation of possible drug-drug interaction between gadoxetic acid and erythromycin as an inhibitor of organic anion transporting peptides (OATP). [2011.02]
PURPOSE: To evaluate if erythromycin compromises liver-specific enhancement of gadoxetic acid; both compounds competing in organic anion transporting peptides (OATP) -mediated hepatocytic uptake... CONCLUSION: Coadministration of erythromycin has no effect on gadoxetic acid enhanced liver MR imaging. Copyright (c) 2011 Wiley-Liss, Inc.
Enhancement of liver parenchyma after injection of hepatocyte-specific MRI contrast media: a comparison of gadoxetic acid and gadobenate dimeglumine. [2010.02]
PURPOSE: To compare enhancement of liver parenchyma in MR imaging after injection of hepatocyte-specific contrast media... CONCLUSION: In the delayed, hepatocyte-specific phase, liver enhancement after injection of gadoxetic acid was superior to that obtained with gadobenate dimeglumine.
Enhancement of liver parenchyma after injection of hepatocyte-specific MRI
contrast media: a comparison of gadoxetic acid and gadobenate dimeglumine. 
of hepatocyte-specific contrast media... CONCLUSION: In the delayed, hepatocyte-specific phase, liver enhancement after
Gadoxetic acid disodium-enhanced hepatocyte phase MRI: Can increasing the flip angle improve focal liver lesion detection? [2011.09.29]
PURPOSE: To determine whether hepatocyte phase gadoxetic acid disodium (EOB)-enhanced MRI using a high flip angle (FA) improves focal liver lesion (FLL) detection compared with using a standard low FA... CONCLUSION: Hepatocyte phase EOB-enhanced MRI with increasing FA can significantly increase LLC and improve the detection of FLLs, particularly small malignant lesions. J. Magn. Reson. Imaging 2011;. (c) 2011 Wiley-Liss, Inc. Copyright (c) 2011 Wiley-Liss, Inc.
Detection, classification, and characterization of focal liver lesions: Value of diffusion-weighted MR imaging, gadoxetic acid-enhanced MR imaging and the combination of both methods. [2011.05.20]
Aim: To evaluate diffusion-weighted MR imaging (DWI), gadoxetic acid-enhanced MR imaging and the combination of both methods in the detection, classification, and characterization of focal liver lesions (FLL). Methods: A total of 119 FLL (28 HCCs, 39 metastases, 15 FNHs, 11 adenomas, 13 hemangiomas, 13 cysts) were retrospectively analyzed in 36 patients...
Clinical Trials Related to Eovist (Gadoxetic Acid)
Primovist / Eovist in Renally Impaired Patients [Recruiting]
Patients with moderate to severe renal impairment scheduled for a magnetic resonance imaging
(MRI) scan and injection with a contrast agent, Primovist/Eovist, will be asked to
The administration of contrast agents that contain gadolinium such as Primovist/Eovist might
increase a potential risk to develop a rare condition called nephrogenic systemic fibrosis
(NSF) in patients with renal impairment. This study is to assess the potential risk to
develop NSF in patients with renal impairment after the administration of Primovist/Eovist.
Patients who are enrolled in this study will receive a Primovist/Eovist enhanced MRI scan
which was prescribed by the referring doctor. After the MRI scan the patient will be
included in a two year follow-up period to assess if signs or symptoms suggestive of NSF
Utility Study of Primovist-MRI on HCC Staging [Recruiting]
Gadoxetic acid (Gd-EOB-DTPA, Primovist)-enhanced MRI can affect on BCLC staging during the
initial staging workups of definite HCC patients with very early or early stage disease, but
with no suspicious intrahepatic HCC lesions by liver dynamic CT.
Liver MRI With Primovist/Eovist in Pediatric Subjects Who Are Suspected or Have Focal Liver Lesions. [Recruiting]
Medical records are reviewed to obtain information about the use of a MRI diagnostic imaging
agent (contrast agent) called Primovist/Eovist in children older than 2 months and less than
18 years. Data that has been recorded in the child's medical records relating to the
injection of Primovist/Eovist will be collected. Information will be collected from up to 2
weeks before the child received Primovist/Eovist until 12 months after the child received
Primovist/Eovist. Copy of the child's MR images that were taken right before and after the
child received Primovist/Eovist and all other reports (laboratory reports, other imaging
reports, etc) that are part of the child's medical records during that time period will be
Comparison of Primovist-enhanced MRI, Diffusion Weighted MRI and Multidetector CT of Colorectal Liver Metastases [Recruiting]
1. Primovist-enhanced Magnetic resonance imaging (MRI) and Diffusion Weighted MRI (DW-MRI)
is superior to Multidetector Computed axial Tomography (MDCT) in the detection of
colorectal liver metastases. Fatty changes in the liver after chemotherapy treatment
likely reduces the chances of seeing metastatic lesions on CT especially when the
lesions are small (<10 mm). When compared with CT, Primovist-enhanced MRI and DW-MRI
have the potential to provide higher contrast resolution enabling better detection of
colorectal liver metastases following chemotherapy.
2. Primovist-enhanced MRI and DW-MRI are superior to CT in assessing and predicting
treatment response of patients with colorectal liver metastases to chemotherapy.
Primovist-enhanced MRI by providing superior resolution may provide improved accuracy
in metastatic lesion margin detection thereby providing higher accuracy in estimating
tumor response based on size criteria. DW-MRI provides information indirectly about
tumor composition and therefore is likely to be superior to MD-CT in assessing
Two groups of patients will be analyzed. The second group consists of patients with
colorectal liver metastases who are to go for chemotherapy prior to surgery for metastases
resection. This group will be CT and MRI scanned prior to chemotherapy and after
chemotherapy. The first group of patients will consist of those patients who have already
received chemotherapy and are likely to have surgery to resect liver metastases. This group
will have only one set of scans done 4-6 weeks prior to their operation. The pathology of
the resected metastases and CT and MRI images will be analyzed and compared.
The Role of Gadoxetate (Eovist) Enhanced CT in Evaluating Cholangiocarcinoma [Recruiting]
The purpose of this project is to evaluate the role of gadoxetate (EovistŪ) enhanced
dual-energy CT in better evaluating perihilar cholangiocarcinoma. This pilot project aims
to address a long-term pitfall in the imaging of cholangiocarcinomas, by providing higher
resolution delineation of these often infiltrative tumors on single-source, Dual-Energy
Spectral Multi Detector CT (MDCT), capitalizing on improved spatial resolution achievable
with MDCT compared to MRI and at the same time producing a non-invasive CT cholangiogram to
aid in accurate diagnosis and treatment planning of cholangiocarcinoma, particularly, the
Reports of Suspected Eovist (Gadoxetic Acid) Side Effects
Chest Discomfort (4),
Throat Irritation (4),
Injection Site Haematoma (2),
Rash Macular (2),
Injection Site Pruritus (2), more >>