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Entocort EC (Budesonide) - Drug Interactions, Contraindications, Overdosage, etc

 
 



DRUG INTERACTIONS

Food Effects

A mean delay in time to peak concentration of 2.5 hours is observed with the intake of a high-fat meal, with no significant differences in AUC.

OVERDOSAGE

Reports of acute toxicity and/or death following overdosage of glucocorticosteroids are rare. Treatment consists of immediate gastric lavage or emesis followed by supportive and symptomatic therapy.

If glucocorticosteroids are used at excessive doses for prolonged periods, systemic glucocorticosteroid effects such as hypercorticism and adrenal suppression may occur. For chronic overdosage in the face of severe disease requiring continuous steroid therapy, the dosage may be reduced temporarily.

Single oral doses of 200 and 400 mg/kg were lethal in female and male mice, respectively. The signs of acute toxicity were decreased motor activity, piloerection and generalized edema.

CONTRAINDICATIONS

ENTOCORT EC is contraindicated in patients with known hypersensitivity to budesonide.

References

1. Fält A, Bengtsson T, Kennedy B, et al. Exposure of infants to budesonide through breast milk of asthmatic mothers. J. Allergy Clin Immunol. 2007;120(4):798-802.

ENTOCORT EC is a trademark of the AstraZeneca group of companies

PROMETHEUS is a trademark of Prometheus Laboratories Inc.

© AstraZeneca 2009

Manufactured by:

AstraZeneca AB

S-151 85 Södertälje, Sweden

Distributed by:

Prometheus Laboratories Inc.

San Diego, CA 92121

Product of Sweden

June 2009

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