NEWS HIGHLIGHTSMedia Articles Related to Enflurane
Patients With Sleep Apnea Undergoing Joint Replacement Have Improved Outcomes With Regional Anesthesia
Source: Arthritis / Rheumatology News From Medical News Today [2013.05.07]
Using regional anesthesia instead of general anesthesia in patients with sleep apnea undergoing total joint replacement decreases major complications by 17%, according to a study published online, ahead of print, in the journal Regional Anesthesia and Pain Medicine...
Lower Rates Of Complications In Hip And Knee Replacement Using Regional Anesthesia Technique
Source: Arthritis / Rheumatology News From Medical News Today [2013.05.03]
A highly underutilized anesthesia technique called neuraxial anesthesia, also known as spinal or epidural anesthesia, improves outcomes in patients undergoing hip or knee replacement, according to a new study by researchers at Hospital for Special Surgery...
General Anesthesia Not Linked to Raised Risk for Dementia
Source: MedicineNet Dementia Specialty [2013.05.02]
Title: General Anesthesia Not Linked to Raised Risk for Dementia
Category: Health News
Created: 5/1/2013 12:35:00 PM
Last Editorial Review: 5/2/2013 12:00:00 AM
Success Rates Of Turning Breech Babies Increased By Anesthesia, Delivery Costs Reduced
Source: Pain / Anesthetics News From Medical News Today [2013.04.22]
When a baby is in the breech position at the end of pregnancy, obstetricians can sometimes turn the baby head-down to enable a safer vaginal birth. In the past, women were not given anesthesia during the turning procedure, which requires the physician to push on the woman's abdomen while monitoring the baby with ultrasound...
Development Of Wisdom Teeth In Children May Be Affected By Dental Anesthesia
Source: Dentistry News From Medical News Today [2013.04.05]
Researchers from Tufts University School of Dental Medicine have discovered a statistical association between the injection of local dental anesthesia given to children ages two to six and evidence of missing lower wisdom teeth...
Published Studies Related to Enflurane
Comparison of effects of anaesthesia with desflurane and enflurane on liver function. [2009.01]
INTRODUCTION: Although most general anaesthesia procedures are performed without any complications, volatile agents may have adverse effects on various living systems. This study aimed to compare the effects of desflurane and enflurane on liver function... CONCLUSION: Subclinical hepatic injury after anaesthesia continues to be an issue of interest, particularly with the development of new, more sensitive methods of measuring GST levels. The increase in GST concentration after anaesthesia is thought to be a result of reduced hepatic blood flow. This study has shown that desflurane has fewer effects than enflurane on liver function tests in lengthy operations of up to 330 minutes.
The effect on the recovery profile of a change from enflurane to desflurane during the latter part of anaesthesia. [2008.09]
This study compared emergence and recovery characteristics after either enflurane anaesthesia or crossover from enflurane to desflurane anaesthesia. At an estimated 1 h prior to the end of operation, enflurane was either reduced (group E, n = 23) or replaced with desflurane (group X, n = 23)... We conclude that, during surgery, the substitution of enflurane with desflurane in the latter part of anaesthesia can improve recovery.
Myocardial metabolism altered by ischemic preconditioning and enflurane in off-pump coronary artery surgery. [2008.06]
OBJECTIVE: During off-pump coronary artery bypass (OPCAB) surgery, the heart is subjected to ischemia and reperfusion. The authors hypothesized that the volatile anesthetics are as effective as ischemic preconditioning (IPC) in preserving myocardial function during off-pump cardiac surgery, and this effect is because of multiple mechanisms of action. Therefore, the effects of enflurane with its calcium inhibition and antioxidative properties were compared with mechanical IPC in preserving myocardial cellular markers... CONCLUSIONS: Coronary occlusion during OPCAB surgery results in increased production of ischemia-related metabolic products. The application of methods such as IPC or volatile anesthesia appears to reduce the metabolic deficit, free-radical production, and physiologic changes.
Enflurane requirement for blocking adrenergic responses to incision in infants and children. [2008.02]
BACKGROUND: Enflurane is one of the most commonly used inhaled anesthetics in China, but its requirement to block adrenergic responses after skin incision in pediatric patients is still unknown. This study was to determine the minimum alveolar anesthetic concentration (MAC) of potent inhaled anesthetics required to blunt the adrenergic response to skin incision of enflurane (MACBAR) in infants and children... CONCLUSIONS: MACBAR of enflurane in infants older than 6 months is similar to that in young children. The MACBAR of enflurane decreases with co-administration of fentanyl in the pediatric population.
Clinical Trials Related to Enflurane
Desflurane and Its Effect on Postoperative Morbidity and Mortality in Patients Undergoing Thoracic Surgery [Recruiting]
Desflurane and its effect on postoperative morbidity and mortality in patients undergoing
thoracic surgery.
Halothane, enflurane, isoflurane, sevoflurane, and desflurane are volatile anesthetics, a
group of general anesthetics. Because of the hypnotic effects of these agents, attention has
mainly focused on the central nervous system. In the last 10 years, however, numerous
studies have reported that volatile anesthetic agents interact with membrane structures of
the myocardium and thereby attenuate cardiac mechanical dysfunction and limit
ultrastructural abnormality on reperfusion after prolonged ischemia in the myocyte.
Anesthetic-induced preconditioning has become a main topic in cardiac research worldwide
- Trial with medicinal product
Sevoflurane and Isoflurane - During Cardiopulmonary Bypass With the MECC System (Minimized Extracorporeal Circuit) [Recruiting]
The use of volatile anesthetics in cardiac anesthesia is very common, because of their
cardioprotective effects and their ability to ensure a sufficient depth of anesthesia. In
line with the development of fast track concepts in cardiac anesthesia, volatile anesthetics
are widely used to avoid a delayed recovery from cardiac surgery and anesthesia. Volatile
anesthetics are delivered from calibrated vaporizers in the anesthesia machine or the
cardiopulmonary bypass machine (during extracorporeal circulation).
Isoflurane and Sevoflurane are the most commonly used volatile anesthetics in patients
undergoing cardiopulmonary bypass (CPB). The vaporizer of the anesthetics is on the
cardiopulmonary bypass machine and the volatile agent is blended with air and oxygen. Until
now, the pharmacokinetics of halothane, enflurane, isoflurane and desflurane during CPB have
been described.
Sevoflurane might be of advantage because of additional myocardial protective effects during
cardiac anesthesia and cardiopulmonary bypass. However, the pharmacokinetics of sevoflurane
during CPB have not been investigated so far, although its being used at many hospitals.
The investigators will conduct a randomized prospective study with either sevoflurane or
isoflurane during cardiopulmonary bypass surgery. The study will help to answer the
questions about the possible cardioprotective effects of the widely used volatile
anesthetics and the hemodynamic stability during cardiopulmonary bypass. Knowing the
pharmacokinetics of these drugs allows the anesthesiologist to titrate the volatile
anesthetics more precise.
The investigators hypothesizes that the maximal postoperative increase in troponin T will be
smaller in the sevoflurane group than in the isoflurane group. The investigators
hypothesizes that the total amount of noradrenaline needed during the entire period of
cardiopulmonary bypass will be smaller in the sevoflurane group than in the isoflurane
group. The investigators hypothesizes that kinetics of washin and washout at the CPB will be
faster in the sevoflurane group than in the isoflurane group. The investigators hypothesizes
that the time to extubation, respectively the length of stay in intensive care unit and
hospital is shorter in the sevoflurane group than in the isoflurane group.
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