ADVERSE REACTIONS
Adverse reactions are usually reversible upon reduction of dosage or discontinuation of ENDURONYL tablets. Whenever adverse reactions are moderate or severe, it may be necessary to discontinue the drug.
The following adverse reactions have been observed, but there has not been enough systematic collection of data to support an estimate of their frequency. Consequently, the reactions are categorized by organ system and are listed in decreasing order of severity and not frequency.
Methyclothiazide
Body as a Whole
Headache, cramping, weakness.
Cardiovascular System
Orthostatic hypotension (may be potentiated by alcohol, barbiturates, or narcotics).
Digestive System
Pancreatitis, jaundice (intrahepatic cholestatic), sialadenitis, vomiting, diarrhea, nausea, gastric irritation, constipation, anorexia.
Hemic and Lymphatic System
Aplastic anemia, hemolytic anemia, agranulocytosis, leukopenia, thrombocytopenia.
Hypersensitivity Reactions
Anaphylactic reactions, necrotizing angiitis (vasculitis, cutaneous vasculitis), Stevens-Johnson syndrome, respiratory distress (including pneumonitis and pulmonary edema), fever, purpura, urticaria, rash, photosensitivity.
Metabolic and Nutritional Disorders
Hyperglycemia, hyperuricemia, electrolyte imbalance (see PRECAUTIONS), hypercalcemia.
Nervous System
Vertigo, dizziness, paresthesias, muscle spasm, restlessness.
Special Senses
Transient blurred vision, xanthopsia.
Urogenital System
Glycosuria.
Deserpidine
Body as a Whole
Headache.
Cardiovascular System
Arrhythmias (particularly when used concurrently with digitalis or quinidine), syncope, angina-like symptoms, bradycardia, fluid retention.
Digestive System
Vomiting, diarrhea, nausea, anorexia, dryness of mouth, hypersecretion, increased motility, increased salivation.
Hemic and Lymphatic System
Thrombocytopenic purpura.
Metabolic and Nutritional Disorders
Weight gain.
Musculoskeletal System
Muscular aches.
Nervous System
Rare parkinsonian syndrome and other extrapyramidal tract symptoms, dizziness, paradoxical anxiety, depression, nervousness, nightmares, dull sensorium, drowsiness, decreased libido.
Respiratory System
Asthma in asthmatic patients, dyspnea, epistaxis, nasal congestion.
Skin and Appendages
Rash, pruritus, flushing of skin.
Special Senses
Deafness, optic atrophy, glaucoma, uveitis, conjunctival injection.
Urogenital System
Nonpuerperal lactation, impotence, dysuria, gynecomastia, breast engorgement.
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