ENDURONYL®
(methyclothiazide and deserpidine)
tablets
oral thiazide-rauwolfia therapy for hypertension.
DESCRIPTION
ENDURONYL tablets are an orally administered combination of Enduron® (methyclothiazide) and deserpidine. ENDURONYL tablets are available in two dosage strengths. ENDURONYL tablets contain methyclothiazide 5 mg and deserpidine 0.25 mg. ENDURONYL FORTE tablets contain methyclothiazide 5 mg and deserpidine 0.5 mg.
Inactive Ingredients
ENDURONYL Tablets
Corn starch, D&C Yellow No. 10, FD&C Yellow No. 6, lactose, magnesium stearate and talc.
ENDURONYL FORTE Tablets
Corn starch, iron oxide, lactose, magnesium stearate and talc.
Methyclothiazide is an oral diuretic-antihypertensive of the benzothiadiazine (thiazide) class of drugs. It occurs as a white to practically white crystalline powder which is basically odorless and has a molecular weight of 360.25. Methyclothiazide is very slightly soluble in water and chloroform, and slightly soluble in alcohol. Chemically, methyclothiazide is represented as 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide.
Deserpidine is a purified rauwolfia alkaloid. It occurs as a white to light yellow crystalline powder and has a molecular weight of 578.64. Deserpidine is insoluble in water and very slightly soluble in alcohol. Chemically, deserpidine is identified as 17α-methoxy-18β-[(3,4,5-trimethoxybenzoyl)oxy]-3β,20α-yohimban-16β-carboxylic acid methyl ester. The structural formulas are:
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| Methyclothiazide | Deserpidine |
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