DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Enalapril and Hydrochlorothiazide (Enalapril Maleate / Hydrochlorothiazide) - Summary

 


Nutrilib.com
A comprihensive source of nutritional information

BOXED WARNING

USE IN PREGNANCY

When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, Enalapril Maleate and Hydrochlorothiazide should be discontinued as soon as possible. See WARNINGS, Pregnancy, Enalapril Maleate, Fetal/Neonatal Morbidity and Mortality.

 

SUMMARY

ENALAPRIL MALEATE AND HYDROCHLOROTHIAZIDE TABLETS USP, 5 mg/12.5 mg and 10 mg/25 mg

Enalapril Maleate and Hydrochlorothiazide combines an angiotensin converting enzyme inhibitor, enalapril maleate, and a diuretic, hydrochlorothiazide. Enalapril maleate is the maleate salt of enalapril, the ethyl ester of a long-acting angiotensin converting enzyme inhibitor, enalaprilat.

Enalapril maleate and hydrochlorothiazide tablets are indicated for the treatment of hypertension.

These fixed dose combinations are not indicated for initial treatment (see DOSAGE AND ADMINISTRATION).

In using enalapril maleate and hydrochlorothiazide, consideration should be given to the fact that another angiotensin converting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen vascular disease, and that available data are insufficient to show that enalapril does not have a similar risk. (See WARNINGS.)

In considering use of enalapril maleate and hydrochlorothiazide, it should be noted that black patients receiving ACE inhibitors have been reported to have a higher incidence of angioedema compared to non-blacks. (See WARNINGS, Angioedema.)


See all Enalapril and Hydrochlorothiazide indications & dosage >>

NEWS HIGHLIGHTS RELATED TO ENALAPRIL AND HYDROCHLOROTHIAZIDE

Media Articles Related to Enalapril and Hydrochlorothiazide (Enalapril / Hydrochlorothiazide)

Hypertension Develops Early, Silently, In African-American Men
Source: Hypertension News From Medical News Today [2008.11.18]

FREEDOM-C Trial Of Oral Treprostinil In Pulmonary Arterial Hypertension Fails To Meet Primary Endpoint
Source: Hypertension News From Medical News Today [2008.11.18]

Hypertension In Europe: A Worrying Scenario
Source: Hypertension News From Medical News Today [2008.11.12]

ASN: Rural Living Seen as Risk Factor for Pregnancy-Induced Hypertension and Preeclampsia
Source: MedPage Today Nephrology [2008.11.12]

Lipoprotein Levels May Predict Women's Hypertension Risk
Source: MedicineNet Cholesterol Specialty [2008.11.12]

more >>

Published Studies Related to Enalapril and Hydrochlorothiazide (Enalapril / Hydrochlorothiazide)

Blood pressure-lowering efficacy of amiloride versus enalapril as add-on drugs in patients with uncontrolled blood pressure receiving hydrochlorothiazide. [2008.10]

Efficacy and safety of lercanidipine versus hydrochlorothiazide as add-on to enalapril in diabetic populations with uncontrolled hypertension. [2006.01]

Cough induced by losartan with resolution after substitution with enalapril. [2008.03]

Reducing blood pressure in SHR with enalapril provokes redistribution of NHE3, NaPi2, and NCC and decreases NaPi2 and ACE abundance. [2007.10]

more >>

Clinical Trials Related to Enalapril and Hydrochlorothiazide (Enalapril / Hydrochlorothiazide)

Comparison of the Antihypertensive Efficacy of Valsartan and Enalapril After Missing One Dose [Completed]

Effect of Enalapril Plus Folic Acid on Blood Pressure and Glycometabolism [Completed]

Antihypertensive Effectiveness of the Associations of Hydrochlorothiazide and Amiloride and Hydrochlorothiazide and Enalapril [Completed]

Long Term Safety, Tolerability and Efficacy of Valsartan and Enalapril Combined and Alone in Children With Hypertension [Recruiting]

Chicken-Diet vs. Enalapril to Reduce Albuminuria [Completed]

more >>

Page last updated: 2008-11-18

-- advertisement -- The American Red Cross

We comply with
HONcode standard.
Verify here.
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2008