Media Articles Related to Emla (Prilocaine / Lidocaine Topical)
Study identifies characteristic EEG pattern of high-dose nitrous oxide anesthesia
Source: Pain / Anesthetics News From Medical News Today [2015.07.07]
While nitrous oxide gas has been used recreationally and medically for more than 200 years - originally for its euphoric and then for its pain relieving and anesthetic properties - the mechanism...
Surgery Patients Might Not Need Sedative Before Anesthesia
Source: MedicineNet lorazepam Specialty [2015.03.04]
Title: Surgery Patients Might Not Need Sedative Before Anesthesia
Category: Health News
Created: 3/3/2015 12:00:00 AM
Last Editorial Review: 3/4/2015 12:00:00 AM
Women With MCI Decline Twice as Fast as Men
Source: Medscape NeurologyHeadlines [2015.07.21]
Women with mild cognitive impairment decline twice as fast as men with MCI, and also have a much higher risk for cognitive problems after surgery and general anesthesia.
Medscape Medical News
For children with autism, trips to the dentist just got easier
Source: Dentistry News From Medical News Today [2015.05.14]
Adjusting the environment to be more soothing could eliminate the need for general anesthesia to cope with routine cleaningsGoing to the dentist might have just gotten a little less scary for the...
Published Studies Related to Emla (Prilocaine / Lidocaine Topical)
EMLA(R) cream: a pain-relieving strategy for childhood vaccination. 
injections... CONCLUSIONS: Application of EMLA® cream can be effectively incorporated as a
Analgesic effects of EMLA cream and oral sucrose during venipuncture in preterm infants. [2011.07]
OBJECTIVE: The goal of this study was to compare the analgesic effect of sucrose with that of the combination of sucrose and the local anesthetic cream EMLA during venipuncture in preterm neonates... CONCLUSION: The combination of sucrose and EMLA cream revealed a higher analgesic effect than sucrose alone during venipuncture in these preterm infants. Copyright (c) 2011 by the American Academy of Pediatrics.
Topical anesthetic EMLA for postoperative wound pain in stereotactic gamma knife radiosurgery: a perspective, randomized, placebo-controlled study. [2011.04]
BACKGROUND: Patients who undergo stereotactic gamma knife radiosurgery (GKRS) need a rigid frame fixation for the stereotactic procedures. Many patients suffered from postoperative wound pain after frame removal. The present study investigated whether an additional application of a topical anesthetic prior to frame removal could reduce this discomfort... CONCLUSION: EMLA when applied 60 min before frame removal has an anesthetic effect of reducing the postoperative wound pain in patients who undergo GKRS. (c) Georg Thieme Verlag KG Stuttgart . New York.
Lidocaine-based topical anesthetic with disinfectant (LidoDin) versus EMLA for venipuncture: a randomized controlled trial. [2009.10]
OBJECTIVE: To examine the efficacy and safety of a new topical anesthetic containing a disinfection ingredient (LidoDin cream) in reducing the pain associated with venipuncture by comparing it with the proven eutectic mixture of lidocaine 2.5% and prilocaine 2.5% (EMLA cream)... Future studies are planned to determine, if LidoDin reduces the rate of local skin infection in patients treated with multiple daily subcutaneous injections of medications.
Topical anesthesia for rubber dam clamp placement in sealant placement: comparison of lidocaine/prilocaine gel and benzocaine. [2009.09]
PURPOSE: The purpose of this prospective study was to compare the efficacy of Oraqix to benzocaine while placing a rubber dam clamp during sealant placement on children... CONCLUSIONS: Application of Oraqix did not reduce discomfort when compared to benzocaine in this small sample size. Oraqix was more effective than benzocaine in the age group 9 and older. A larger sample size is needed to determine its efficacy in children younger than 9years old.
Clinical Trials Related to Emla (Prilocaine / Lidocaine Topical)
Study of Fentanyl-Propofol-EMLA of L.M.X4 Technique for Bone Marrow Aspiration [Active, not recruiting]
St. Jude Children's Research Hospital is studying the best ways to prevent pain during and
after procedures such as bone marrow aspiration and lumbar puncture with intrathecal (in the
spinal fluid) chemotherapy. Researchers will study the effectiveness of combining anesthetics
(medicines that help people sleep) and analgesics (medicines that relieve pain). Researchers
believe that a combination of fentanyl (analgesic) and propofol (anesthetic), along with
applying the skin-numbing-cream EMLA or L. M.X4™ on the area where the procedure is performed,
will provide better pain control.
Each patient enrolled on this study will have three different anesthetic combinations for
three different procedures, in order to determine which combination worked best for each
Randomised Trial of Eutectic Mixture of Local Anaesthetics Cream and Oral Sucrose Solution for Venepuncture [Not yet recruiting]
This randomized bicentric trial will investigate the efficacy of topical EMLA cream with
oral sucrose solution compared to oral sucrose solution alone before venepuncture in preterm
Evaluation of Analgesia With EMLA and Glucose Oral Solution in Preterm Neonates During Arterial Puncture and PICC Installation [Recruiting]
Improvement of Sensibility in the Foot in Diabetic Patients Induced by EMLA-application to the Lower Leg [Recruiting]
Sensory input from the foot as well as all other body parts results in activation of sensory
It is well known that the cortical body map is experienced-dependant and can rapidly change
in response to changes in activity and sensory input from the periphery [10-12]. Increased
activity and sensory input from the hand results in expansion of the cortical hand
representation [13-15], while decreased sensory input, for instance by anaesthesia,
amputation or nerve injury, results in shrinkage of the cortical hand representation
[16-21]. Due to the constant ongoing "cortical competition" between body parts the adjacent
cortical areas expand and take over the silent area, deprived of sensory input.
The investigators have recently described striking examples of such rapid cortical
re-organisations induced by selective cutaneous anaesthesia of the forearm: application of
EMLA cream to the volar aspect of the forearm results in improved sensory functions of the
hand  linked to expansion of the hand representational area in sensory cortex . In
analogy, EMLA application to the lower leg in healthy controls results in improved sensory
functions in the sole of the foot linked to expansion of the foot representational area in
To test the hypothesis that EMLA application to the lower leg of diabetic patients will
result in improved sensory functions in the sole of the foot as well as expansion of the
foot representation in sensory cortex. The investigators hypothesize that repeated
applications of EMLA will result in a long lasting sensibility improvement.
Acute Response Capsaicin Flare Study [Recruiting]
Prior to administering PF-04427429 to patients we wish to increase the understanding of
functional effects associated with calcitonin gene related peptide (CGRP) pathways. This
study will examine whether it is possible for a single dose of PF-04427429 to acutely
attenuate a capsaicin induced flare response.
Reports of Suspected Emla (Prilocaine / Lidocaine Topical) Side Effects
LIP Oedema (2),
Face Oedema (2),
Application Site Erythema (2), more >>