EMLA Cream (lidocaine 2.5% and prilocaine 2.5%) is an emulsion in which the oil phase is a eutectic mixture of lidocaine and prilocaine in a ratio of 1:1 by weight. This eutectic mixture has a melting point below room temperature and therefore both local anesthetics exist as a liquid oil rather than as crystals. It is packaged in 5 gram and 30 gram tubes.
EMLA Cream (a eutectic mixture of lidocaine 2.5% and prilocaine 2.5%) is indicated as a topical anesthetic for use on:
- normal intact skin for local analgesia.
- genital mucous membranes for superficial minor surgery and as pretreatment for infiltration anesthesia.
EMLA Cream is not recommended in any clinical situation when penetration or migration beyond the tympanic membrane into the middle ear is possible because of the ototoxic effects observed in animal studies (see WARNINGS).
Media Articles Related to Emla (Prilocaine / Lidocaine Topical)
The Evaluation of Clinical Superiority in Anesthesia Trials
Source: Medscape Anesthesiology Headlines [2016.10.19]
The authors propose a cognitive forcing strategy to avoid the pitfall of making judgments about the clinical superiority of an intervention on the basis of statistical significance alone.
British Journal of Anaesthesia
Transcarotid TAVR May Often Avoid General Anesthesia
Source: theheart.org | Medscape Cardiology Headlines [2016.10.18]
Using local anesthesia with conscious sedation might have cut the risk of periprocedural strokes a small transcarotid-TAVR series; the patients had severe peripheral vascular disease.
Heartwire from Medscape
Transcarotid TAVR Safer Under Local Anesthesia
Source: MedPage Today Nephrology [2016.10.17]
(MedPage Today) -- Early events only seen in general anesthesia cases in French series
Postoperative Delirium, Cognitive Changes Theme of ASA 2016
Source: Medscape Anesthesiology Headlines [2016.10.21]
New data from major clinical trials, the effect of anesthesia on the brain, and chronic opioid use will be addressed at Anesthesiology 2016.
Medscape Medical News
Published Studies Related to Emla (Prilocaine / Lidocaine Topical)
EMLA(R) cream: a pain-relieving strategy for childhood vaccination. 
injections... CONCLUSIONS: Application of EMLA┬« cream can be effectively incorporated as a
Analgesic effects of EMLA cream and oral sucrose during venipuncture in preterm infants. [2011.07]
OBJECTIVE: The goal of this study was to compare the analgesic effect of sucrose with that of the combination of sucrose and the local anesthetic cream EMLA during venipuncture in preterm neonates... CONCLUSION: The combination of sucrose and EMLA cream revealed a higher analgesic effect than sucrose alone during venipuncture in these preterm infants. Copyright (c) 2011 by the American Academy of Pediatrics.
Topical anesthetic EMLA for postoperative wound pain in stereotactic gamma knife radiosurgery: a perspective, randomized, placebo-controlled study. [2011.04]
BACKGROUND: Patients who undergo stereotactic gamma knife radiosurgery (GKRS) need a rigid frame fixation for the stereotactic procedures. Many patients suffered from postoperative wound pain after frame removal. The present study investigated whether an additional application of a topical anesthetic prior to frame removal could reduce this discomfort... CONCLUSION: EMLA when applied 60 min before frame removal has an anesthetic effect of reducing the postoperative wound pain in patients who undergo GKRS. (c) Georg Thieme Verlag KG Stuttgart . New York.
Lidocaine-based topical anesthetic with disinfectant (LidoDin) versus EMLA for venipuncture: a randomized controlled trial. [2009.10]
OBJECTIVE: To examine the efficacy and safety of a new topical anesthetic containing a disinfection ingredient (LidoDin cream) in reducing the pain associated with venipuncture by comparing it with the proven eutectic mixture of lidocaine 2.5% and prilocaine 2.5% (EMLA cream)... Future studies are planned to determine, if LidoDin reduces the rate of local skin infection in patients treated with multiple daily subcutaneous injections of medications.
Topical anesthesia for rubber dam clamp placement in sealant placement: comparison of lidocaine/prilocaine gel and benzocaine. [2009.09]
PURPOSE: The purpose of this prospective study was to compare the efficacy of Oraqix to benzocaine while placing a rubber dam clamp during sealant placement on children... CONCLUSIONS: Application of Oraqix did not reduce discomfort when compared to benzocaine in this small sample size. Oraqix was more effective than benzocaine in the age group 9 and older. A larger sample size is needed to determine its efficacy in children younger than 9years old.
Clinical Trials Related to Emla (Prilocaine / Lidocaine Topical)
Evaluation of Analgesia With EMLA and Glucose Oral Solution [Completed]
Jet Injection of 1% Buffered Lidocaine Versus Topical EMLA for Local Anesthesia Before Lumbar Puncture in Children [Enrolling by invitation]
The purpose of this study is to evaluate the effectiveness of a needle-free jet-injection
system with 1% buffered lidocaine for local anesthesia for lumbar punctures compared to a
topical anesthetic agent. Our hypothesis is: A needle-free jet-injection system (J-Tip)
with 1% lidocaine will provide local anesthesia that is comparable to that of a topical
anesthetic agent (EMLA cream) when performing lumbar punctures in children.
Efficacy Trial of Eutectic Lidocaine/Prilocaine Cream 5% (EMLA) for Analgesia Prior to Cryotherapy of Verrucae Plantaris [Recruiting]
The investigators main purpose is to assess the efficacy of analgesia provide by topical
lidocaine/prilocaine cream 5% (EMLA)« to pared plantar warts prior to application of liquid
nitrogen cryotherapy in adults.
Treating Tinnitus Using Eutectic Mixture of Local Anesthetics (EMLA) 5% Cream [Not yet recruiting]
The investigators like to learn whether EMLA cream 5% helps tinnitus patients. so far it is
known that lidocaine I. V do helps tinnitus but until now it is not clear if topical
anaesthetics (e. g EMLA cream) helps tinnitus.
The investigators are going to compare 4 days of treatment of EMLA 5% cream Versus (VS.)
cetomacrogol cream (water- based lotion cream) in treating tinnitus patients.
Evaluation of the Analgesy With Emla and/or Nitrous Oxide in Pediatric Patients for Lumbar Puncture [Completed]
Reports of Suspected Emla (Prilocaine / Lidocaine Topical) Side Effects
LIP Oedema (2),
Face Oedema (2),
Application Site Erythema (2), more >>