DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Emla (Prilocaine / Lidocaine Topical) - Summary



(lidocaine 2.5% and prilocaine 2.5%)

EMLA Cream (lidocaine 2.5% and prilocaine 2.5%) is an emulsion in which the oil phase is a eutectic mixture of lidocaine and prilocaine in a ratio of 1:1 by weight. This eutectic mixture has a melting point below room temperature and therefore both local anesthetics exist as a liquid oil rather than as crystals. It is packaged in 5 gram and 30 gram tubes.

EMLA Cream (a eutectic mixture of lidocaine 2.5% and prilocaine 2.5%) is indicated as a topical anesthetic for use on:

- normal intact skin for local analgesia.

- genital mucous membranes for superficial minor surgery and as pretreatment for infiltration anesthesia.

EMLA Cream is not recommended in any clinical situation when penetration or migration beyond the tympanic membrane into the middle ear is possible because of the ototoxic effects observed in animal studies (see WARNINGS).

See all Emla indications & dosage >>


Media Articles Related to Emla (Prilocaine / Lidocaine Topical)

Better Outcomes With Local Anesthesia for Stroke Treatments
Source: Medscape NeurologyHeadlines [2014.11.10]
Local beats general anesthesia in terms of functional outcomes for endovascular procedures to treat acute ischemic stroke, a retrospective study shows.
Medscape Medical News

Anesthesia-related postoperative cognitive impairment
Source: Pain / Anesthetics News From Medical News Today [2014.11.05]
General anesthesia results in extended cognitive decline for many individuals following surgical procedure. Memory deficits can last for months and affect patient outcome and quality of life.

Study shows anesthesia-related deaths decline; improvement needed to reduce injuries
Source: Pain / Anesthetics News From Medical News Today [2014.10.17]
Although recent trends show a decline in anesthesia-related deaths, a study published today by the Journal of Healthcare Risk Management concludes that risks are evolving and both physicians and...

Risks From Epidural, Spinal Anesthesia Very Low, Study Says
Source: MedicineNet Pregnancy Drug Dangers Specialty [2014.10.15]
Title: Risks From Epidural, Spinal Anesthesia Very Low, Study Says
Category: Health News
Created: 10/14/2014 12:00:00 AM
Last Editorial Review: 10/15/2014 12:00:00 AM

The Death of Joan Rivers: Endoscopy and Anesthesia Risks
Source: MedicineNet Heart Attack and Atherosclerosis Prevention Specialty [2014.09.08]
Title: The Death of Joan Rivers: Endoscopy and Anesthesia Risks
Category: Doctor's Views
Created: 9/8/2014 12:58:00 PM
Last Editorial Review: 9/8/2014 12:58:43 PM

more news >>

Published Studies Related to Emla (Prilocaine / Lidocaine Topical)

Analgesic effects of EMLA cream and oral sucrose during venipuncture in preterm infants. [2011.07]
OBJECTIVE: The goal of this study was to compare the analgesic effect of sucrose with that of the combination of sucrose and the local anesthetic cream EMLA during venipuncture in preterm neonates... CONCLUSION: The combination of sucrose and EMLA cream revealed a higher analgesic effect than sucrose alone during venipuncture in these preterm infants. Copyright (c) 2011 by the American Academy of Pediatrics.

Topical anesthetic EMLA for postoperative wound pain in stereotactic gamma knife radiosurgery: a perspective, randomized, placebo-controlled study. [2011.04]
BACKGROUND: Patients who undergo stereotactic gamma knife radiosurgery (GKRS) need a rigid frame fixation for the stereotactic procedures. Many patients suffered from postoperative wound pain after frame removal. The present study investigated whether an additional application of a topical anesthetic prior to frame removal could reduce this discomfort... CONCLUSION: EMLA when applied 60 min before frame removal has an anesthetic effect of reducing the postoperative wound pain in patients who undergo GKRS. (c) Georg Thieme Verlag KG Stuttgart . New York.

Lidocaine-based topical anesthetic with disinfectant (LidoDin) versus EMLA for venipuncture: a randomized controlled trial. [2009.10]
OBJECTIVE: To examine the efficacy and safety of a new topical anesthetic containing a disinfection ingredient (LidoDin cream) in reducing the pain associated with venipuncture by comparing it with the proven eutectic mixture of lidocaine 2.5% and prilocaine 2.5% (EMLA cream)... Future studies are planned to determine, if LidoDin reduces the rate of local skin infection in patients treated with multiple daily subcutaneous injections of medications.

Topical anesthesia for rubber dam clamp placement in sealant placement: comparison of lidocaine/prilocaine gel and benzocaine. [2009.09]
PURPOSE: The purpose of this prospective study was to compare the efficacy of Oraqix to benzocaine while placing a rubber dam clamp during sealant placement on children... CONCLUSIONS: Application of Oraqix did not reduce discomfort when compared to benzocaine in this small sample size. Oraqix was more effective than benzocaine in the age group 9 and older. A larger sample size is needed to determine its efficacy in children younger than 9years old.

EMLA cream for carpal tunnel syndrome: how it compares with steroid injection. [2009.09]
BACKGROUND: A standard treatment option for carpal tunnel syndrome (CTS) is local injection of anesthetic-corticosteroid. This clinical trial was designed to compare the safety and efficacy of daily application of the EMLA cream (lidocaine 2.5% plus prilocaine 2.5%) with that of a single injection of methyl prednisolone acetate (Depo-Medrol) 40 mg... CONCLUSION: EMLA cream was effective in reducing pain associated with CTS and well tolerated and it may offer patients with CTS an effective, noninvasive symptomatic treatment.

more studies >>

Clinical Trials Related to Emla (Prilocaine / Lidocaine Topical)

Study of Fentanyl-Propofol-EMLA of L.M.X4 Technique for Bone Marrow Aspiration [Active, not recruiting]
St. Jude Children's Research Hospital is studying the best ways to prevent pain during and after procedures such as bone marrow aspiration and lumbar puncture with intrathecal (in the spinal fluid) chemotherapy. Researchers will study the effectiveness of combining anesthetics (medicines that help people sleep) and analgesics (medicines that relieve pain). Researchers believe that a combination of fentanyl (analgesic) and propofol (anesthetic), along with applying the skin-numbing-cream EMLA or L. M.X4™ on the area where the procedure is performed, will provide better pain control.

Each patient enrolled on this study will have three different anesthetic combinations for three different procedures, in order to determine which combination worked best for each child.

Randomised Trial of Eutectic Mixture of Local Anaesthetics Cream and Oral Sucrose Solution for Venepuncture [Not yet recruiting]
This randomized bicentric trial will investigate the efficacy of topical EMLA cream with oral sucrose solution compared to oral sucrose solution alone before venepuncture in preterm infants.

Evaluation of Analgesia With EMLA and Glucose Oral Solution in Preterm Neonates During Arterial Puncture and PICC Installation [Recruiting]

Lidocaine-Prilocaine (EMLA) Cream as Analgesia in Hysterosalpingography Practice [Not yet recruiting]

Local Anesthetic Cream in Younger Patients Undergoing Lumbar Punctures [Recruiting]
This randomized clinical trial studies local anesthetic (EMLA) cream in younger patients undergoing lumbar punctures (LP). A local anesthetic cream may be effective for numbing the skin and reducing movement when applied prior to lumbar punctures and may reduce the amount of sedation necessary

more trials >>

Reports of Suspected Emla (Prilocaine / Lidocaine Topical) Side Effects

Methaemoglobinaemia (4)Somnolence (4)Overdose (3)Paraesthesia (3)Hypersensitivity (2)Hyperthermia (2)LIP Oedema (2)Face Oedema (2)Cyanosis (2)Application Site Erythema (2)more >>

Page last updated: 2014-11-10

-- advertisement -- The American Red Cross
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2014