Media Articles Related to Eloxatin (Oxaliplatin)
Postop Complications and Survival in Colorectal Cancer
Source: Medscape Headlines [2015.05.18]
What is the association of postoperative complications with long-term survival after colorectal cancer resection?
Annals of Surgery
Oral milk thistle extract stops colorectal cancer stem cells from growing tumors
Source: Colorectal Cancer News From Medical News Today [2015.04.22]
In results presented at the American Association for Cancer Research (AACR) Annual Meeting 2015, a University of Colorado Cancer Center study shows that orally administering the chemical silibinin...
ASCP, CAP, AMP, and ASCO issue draft colorectal cancer molecular marker testing guideline and announce opening of public comment period
Source: Colorectal Cancer News From Medical News Today [2015.04.01]
The American Society for Clinical Pathology (ASCP), the College of American Pathologists (CAP), the Association for Molecular Pathology (AMP), and the American Society of Clinical Oncology (ASCO)...
Bio-marker set forms the basis for new blood test to detect colorectal cancer
Source: Colorectal Cancer News From Medical News Today [2015.03.30]
Colorectal cancer is the third most common form of cancer globally and the second most common cause of cancer deaths.
High intake of marine omega-3 polyunsaturated fatty acids associated with lower risk of MSI colorectal cancers
Source: Colorectal Cancer News From Medical News Today [2015.03.30]
High intake of marine omega-3 polyunsaturated fatty acids (PUFAs) is associated with lower risk of microsatellite instable (MSI) colorectal cancers (CRCs) but not microsatellite stable (MSS) CRCs...
Published Studies Related to Eloxatin (Oxaliplatin)
Phase III randomized, placebo-controlled, double-blind study of intravenous
calcium and magnesium to prevent oxaliplatin-induced sensory neurotoxicity
whether calcium/magnesium decreases oxaliplatin-related neurotoxicity... CONCLUSION: This study does not support using calcium/magnesium to protect
Phase I drug-interaction study of effects of calcium and magnesium infusions on
oxaliplatin pharmacokinetics and acute neurotoxicity in colorectal cancer
hyperexcitability and acute neurotoxicity symptoms are unclear... CONCLUSIONS: Ca/Mg infusions do not alter the clinical pharmacokinetics of
Primary tumor response to preoperative chemoradiation with or without oxaliplatin in locally advanced rectal cancer: pathologic results of the STAR-01 randomized phase III trial. [2011.07.10]
PURPOSE: To investigate oxaliplatin combined with fluorouracil-based chemoradiotherapy as preoperative treatment for locally advanced rectal cancer... CONCLUSION: Adding oxaliplatin to fluorouracil-based preoperative chemoradiotherapy significantly increases toxicity without affecting primary tumor response. Longer follow-up is needed to assess the impact on efficacy end points.
Intermittent versus continuous oxaliplatin and fluoropyrimidine combination chemotherapy for first-line treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. [2011.07]
BACKGROUND: When cure is impossible, cancer treatment should focus on both length and quality of life. Maximisation of time without toxic effects could be one effective strategy to achieve both of these goals. The COIN trial assessed preplanned treatment holidays in advanced colorectal cancer to achieve this aim... INTERPRETATION: Although this trial did not show non-inferiority of intermittent compared with continuous chemotherapy for advanced colorectal cancer in terms of overall survival, chemotherapy-free intervals remain a treatment option for some patients with advanced colorectal cancer, offering reduced time on chemotherapy, reduced cumulative toxic effects, and improved quality of life. Subgroup analyses suggest that patients with normal baseline platelet counts could gain the benefits of intermittent chemotherapy without detriment in survival, whereas those with raised baseline platelet counts have impaired survival and quality of life with intermittent chemotherapy and should not receive a treatment break. FUNDING: Cancer Research UK. Copyright (c) 2011 Elsevier Ltd. All rights reserved.
Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. [2011.06.18]
BACKGROUND: In the Medical Research Council (MRC) COIN trial, the epidermal growth factor receptor (EGFR)-targeted antibody cetuximab was added to standard chemotherapy in first-line treatment of advanced colorectal cancer with the aim of assessing effect on overall survival... INTERPRETATION: This trial has not confirmed a benefit of addition of cetuximab to oxaliplatin-based chemotherapy in first-line treatment of patients with advanced colorectal cancer. Cetuximab increases response rate, with no evidence of benefit in progression-free or overall survival in KRAS wild-type patients or even in patients selected by additional mutational analysis of their tumours. The use of cetuximab in combination with oxaliplatin and capecitabine in first-line chemotherapy in patients with widespread metastases cannot be recommended. FUNDING: Cancer Research UK, Cancer Research Wales, UK Medical Research Council, Merck KGgA. Copyright (c) 2011 Elsevier Ltd. All rights reserved.
Clinical Trials Related to Eloxatin (Oxaliplatin)
XELOX III. Xeloda in Combination With Eloxatin for Patients With Advanced or Metastatic Colorectal Cancer [Active, not recruiting]
XELOX (Capecitabine and Oxaliplatin) is an effective and convenient regimen for patients with
metastatic colorectal cancer. Chronomodulated therapy may reduce toxicity. Patients will be
randomized to standard XELOX (Capecitabine 1000 mg/m˛ in the morning and 1000 mg/m˛ in the
evening days 1-14 and short term Oxaliplatin 130 mg/m˛ day 1 in 30 minutes) or
chronomodulated XELOX (Capecitabine 400 mg/m˛ in the morning and 1600 mg/m˛ in the evening
days 1-14 and short term Oxaliplatin 130 mg/m˛ day 1 in 30 minutes).
Bloodsamples will be collected and frozen and later examined for potential predictive
Oxaliplatin and S-1 (OS) Versus Oxaliplatin and Capecitabine (XELOX) for Advanced Colorectal Cancer [Recruiting]
The aim of this study is to compare the activity and safety of Oxaliplatin and S-1 (OS) and
Oxaliplatin and Capecitabine (XELOX) in patients with advance or recurrent colorectal
Study of S-1 and Oxaliplatin (SOX) Versus Capecitabine and Oxaliplatin (COX) in Patients With Advanced Colorectal Cancer [Recruiting]
Primary objective :
To compare the combination of S-1 and oxaliplatin(SOX) to the combination of capecitabine
and oxaliplatin(COX) therapy for advanced or metastatic colorectal carcinoma.
Secondary objectives :
1. To evaluate and compare the efficacy (overall survival and response rate) in the two
2. To evaluate and compare the quality of life of the patients and safety profiles of
the two treatment groups.
XAD - Xelox (Capecitabine + Oxaliplatin) + Bevacizumab + Dasatinib [Recruiting]
The primary purpose of this study is to find the highest tolerated dose of the study drugs:
capecitabine, oxaliplatin, bevacizumab, and dasatinib given in combination to subjects with
advanced solid tumors. This will occur in the first part of the study (Phase I). Once this
dose has been determined, it will be given to subjects with advanced metastatic colorectal
cancer in the second part of the study (Phase II).
By giving these drugs in combination, researchers hope to evaluate the side effects of the
study drugs in both groups, and to determine if this combination could possibly decrease or
stabilize the cancer being treated.
Subjects will be enrolled at Duke University Medical Center (DUMC) and Rocky Mountain
After satisfying eligibility and screening criteria, patients will be treated on 21 day
ABOUT THE STUDY DRUGS
- Capecitabine (Xelodaâ„˘) is an oral (taken by mouth) chemotherapy drug in tablet form
made by Roche Laboratories Inc. Capecitabine has been approved for use by the Food and
Drug Administration (FDA) for first line treatment (treatment that should be used for
cancer that has not been treated yet) of metastatic colorectal cancer and also for
metastatic breast cancer.
- Oxaliplatin (Eloxatinâ„˘) is an intravenous (given by injection into a vein) chemotherapy
drug made by Sanofi-SynthĂ©labo. This drug is also approved by the FDA for use in
metastatic colorectal cancer.
- Bevacizumab (Avastinâ„˘) is a type of intravenous cancer treatment called anti-angiogenic
therapy (a type of therapy to treat cancer that interferes with blood flow to the
tumor, thereby stopping tumor growth, and possibly leading to tumor shrinkage) made by
Genentech Inc. Bevacizumab is approved by the FDA for first line treatment of
metastatic colorectal cancer in combination with other chemotherapy.
- Dasatinib (Sprycelâ„˘) is an oral drug made by BMS, Inc. Dasatinib is approved by the
FDA for the treatment of chronic myeloid leukemia (CML), acute lymphoblastic leukemia
or for patients that are resistant to a medicine called imatinib mesylate (Gleevecâ„˘ ).
Oxaliplatin and Capecitabine in Patients With Unresectable Cholangiocarcinoma [Active, not recruiting]
This is a Phase II trial of the combination of oxaliplatin (Eloxatin) and capecitabine
(Xeloda), known as XELOX, in patients with unresectable or recurrent cholangiocarcinoma,
including carcinoma of the gallbladder or biliary tract, both intrahepatic and extrahepatic.
Patients may be either previously untreated or treated with chemotherapy. Patients will
accrue to two strata based on pre-treatment status; separate response rates and statistical
operating characteristics will be applied to each stratum.
The primary objective is to determine the objective response rate (complete plus partial) of
XELOX in this population.
Secondary objectives include determining toxicity, stable disease rates, and median and
overall survival of patients treated with this combination.
Reports of Suspected Eloxatin (Oxaliplatin) Side Effects
Abdominal Pain (18),
Renal Failure Acute (12),
Asthenia (12), more >>