Media Articles Related to Eloxatin (Oxaliplatin)
Gene variant makes eaters of processed meat 'more likely to get colorectal cancer'
Source: Cancer / Oncology News From Medical News Today [2014.04.18]
Researchers have found that a common gene variant - carried by 1 in 3 people - may increase risk of colorectal cancer in individuals who eat processed meat.
Older Patients Fare Less Well After Colorectal Cancer Surgery
Source: Medscape Gastroenterology Headlines [2014.04.15]
Although there's been a reduction in US colorectal cancer operations as well as improved outcome in recent years, the elderly still don't do as well as younger patients, according to California-based researchers.
Reuters Health Information
Cetuximab used with chemotherapy to treat advanced colorectal cancer may result in more rapid cancer progression
Source: Colorectal Cancer News From Medical News Today [2014.04.10]
Research from the University of Southampton has shown a drug, used in combination with chemotherapy to treat advanced colorectal cancer, is not effective in some settings, and indeed may result in...
Patients over 65 have more complications after colorectal cancer surgery
Source: Colorectal Cancer News From Medical News Today [2014.04.09]
Most colorectal cancer surgeries are performed on patients older than 65 years, and older patients have worse outcomes than younger patients, although the total number of colon cancer operations...
Adenoma detection rates linked to colorectal cancer and mortality
Source: Colorectal Cancer News From Medical News Today [2014.04.02]
A study of over 224,000 patients and more than 314,000 colonoscopies found that adenoma detection rates closely tracked the future risk of colorectal cancer.
Published Studies Related to Eloxatin (Oxaliplatin)
Primary tumor response to preoperative chemoradiation with or without oxaliplatin in locally advanced rectal cancer: pathologic results of the STAR-01 randomized phase III trial. [2011.07.10]
PURPOSE: To investigate oxaliplatin combined with fluorouracil-based chemoradiotherapy as preoperative treatment for locally advanced rectal cancer... CONCLUSION: Adding oxaliplatin to fluorouracil-based preoperative chemoradiotherapy significantly increases toxicity without affecting primary tumor response. Longer follow-up is needed to assess the impact on efficacy end points.
Intermittent versus continuous oxaliplatin and fluoropyrimidine combination chemotherapy for first-line treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. [2011.07]
BACKGROUND: When cure is impossible, cancer treatment should focus on both length and quality of life. Maximisation of time without toxic effects could be one effective strategy to achieve both of these goals. The COIN trial assessed preplanned treatment holidays in advanced colorectal cancer to achieve this aim... INTERPRETATION: Although this trial did not show non-inferiority of intermittent compared with continuous chemotherapy for advanced colorectal cancer in terms of overall survival, chemotherapy-free intervals remain a treatment option for some patients with advanced colorectal cancer, offering reduced time on chemotherapy, reduced cumulative toxic effects, and improved quality of life. Subgroup analyses suggest that patients with normal baseline platelet counts could gain the benefits of intermittent chemotherapy without detriment in survival, whereas those with raised baseline platelet counts have impaired survival and quality of life with intermittent chemotherapy and should not receive a treatment break. FUNDING: Cancer Research UK. Copyright (c) 2011 Elsevier Ltd. All rights reserved.
Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. [2011.06.18]
BACKGROUND: In the Medical Research Council (MRC) COIN trial, the epidermal growth factor receptor (EGFR)-targeted antibody cetuximab was added to standard chemotherapy in first-line treatment of advanced colorectal cancer with the aim of assessing effect on overall survival... INTERPRETATION: This trial has not confirmed a benefit of addition of cetuximab to oxaliplatin-based chemotherapy in first-line treatment of patients with advanced colorectal cancer. Cetuximab increases response rate, with no evidence of benefit in progression-free or overall survival in KRAS wild-type patients or even in patients selected by additional mutational analysis of their tumours. The use of cetuximab in combination with oxaliplatin and capecitabine in first-line chemotherapy in patients with widespread metastases cannot be recommended. FUNDING: Cancer Research UK, Cancer Research Wales, UK Medical Research Council, Merck KGgA. Copyright (c) 2011 Elsevier Ltd. All rights reserved.
Prospective, randomized trial comparing 5-FU/LV with or without oxaliplatin as adjuvant treatment following curative resection of gastric adenocarcinoma. [2011.06]
BACKGROUND: To investigate the efficacy and toxicity of FOLFOX4 regimen and LV5Fu2 regimen in patients with advanced gastric adenocarcinoma after curative gastrectomy... CONCLUSION: FOLFOX4 regimen showed good efficacy and an acceptable safety profile for patients with advanced gastric adenocarcinoma after curative gastrectomy compared with the control group. It may prove to be a suitable alterative regimen in this indication. Copyright (c) 2011 Elsevier Ltd. All rights reserved.
Randomized, placebo-controlled, phase III study of first-line oxaliplatin-based chemotherapy plus PTK787/ZK 222584, an oral vascular endothelial growth factor receptor inhibitor, in patients with metastatic colorectal adenocarcinoma. [2011.05.20]
PURPOSE: PTK787/ZK 222584 (PTK/ZK; vatalanib), an orally active, multitargeted angiogenesis inhibitor, has shown tolerability and promising activity in early-phase studies, which led to a phase III trial in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4)... CONCLUSION: Although the efficacy objectives of this study were not met, a subgroup of patients who may potentially benefit from small-molecule vascular endothelial growth factor receptor inhibitor therapy has been identified and further research is warranted.
Clinical Trials Related to Eloxatin (Oxaliplatin)
XELOX III. Xeloda in Combination With Eloxatin for Patients With Advanced or Metastatic Colorectal Cancer [Active, not recruiting]
XELOX (Capecitabine and Oxaliplatin) is an effective and convenient regimen for patients with
metastatic colorectal cancer. Chronomodulated therapy may reduce toxicity. Patients will be
randomized to standard XELOX (Capecitabine 1000 mg/m˛ in the morning and 1000 mg/m˛ in the
evening days 1-14 and short term Oxaliplatin 130 mg/m˛ day 1 in 30 minutes) or
chronomodulated XELOX (Capecitabine 400 mg/m˛ in the morning and 1600 mg/m˛ in the evening
days 1-14 and short term Oxaliplatin 130 mg/m˛ day 1 in 30 minutes).
Bloodsamples will be collected and frozen and later examined for potential predictive
Oxaliplatin and S-1 (OS) Versus Oxaliplatin and Capecitabine (XELOX) for Advanced Colorectal Cancer [Recruiting]
The aim of this study is to compare the activity and safety of Oxaliplatin and S-1 (OS) and
Oxaliplatin and Capecitabine (XELOX) in patients with advance or recurrent colorectal
Biweekly Intraperitoneal Oxaliplatin With Systemic Capecitabine and Bevacizumab for Patients With Peritoneal Carcinomatosis From Appendiceal or Colorectal Cancer [Recruiting]
This study is to test escalating doses of intraperitoneal (IP) oxaliplatin in conjunction
with systemic bevacizumab and capecitabine in patients with Peritoneal Carcinomatosis (PC)
from either appendiceal or colorectal adenocarcinoma that have been adequately cytoreduced
and have undergone a peritoneal scan demonstrating patency of at least one of the
intraperitoneal ports that were placed at the time of debulking.
Study of S-1 and Oxaliplatin (SOX) Versus Capecitabine and Oxaliplatin (COX) in Patients With Advanced Colorectal Cancer [Recruiting]
Primary objective :
To compare the combination of S-1 and oxaliplatin(SOX) to the combination of capecitabine
and oxaliplatin(COX) therapy for advanced or metastatic colorectal carcinoma.
Secondary objectives :
1. To evaluate and compare the efficacy (overall survival and response rate) in the two
2. To evaluate and compare the quality of life of the patients and safety profiles of
the two treatment groups.
XAD - Xelox (Capecitabine + Oxaliplatin) + Bevacizumab + Dasatinib [Recruiting]
The primary purpose of this study is to find the highest tolerated dose of the study drugs:
capecitabine, oxaliplatin, bevacizumab, and dasatinib given in combination to subjects with
advanced solid tumors. This will occur in the first part of the study (Phase I). Once this
dose has been determined, it will be given to subjects with advanced metastatic colorectal
cancer in the second part of the study (Phase II).
By giving these drugs in combination, researchers hope to evaluate the side effects of the
study drugs in both groups, and to determine if this combination could possibly decrease or
stabilize the cancer being treated.
Subjects will be enrolled at Duke University Medical Center (DUMC) and Rocky Mountain
After satisfying eligibility and screening criteria, patients will be treated on 21 day
ABOUT THE STUDY DRUGS
- Capecitabine (Xelodaâ„˘) is an oral (taken by mouth) chemotherapy drug in tablet form
made by Roche Laboratories Inc. Capecitabine has been approved for use by the Food and
Drug Administration (FDA) for first line treatment (treatment that should be used for
cancer that has not been treated yet) of metastatic colorectal cancer and also for
metastatic breast cancer.
- Oxaliplatin (Eloxatinâ„˘) is an intravenous (given by injection into a vein) chemotherapy
drug made by Sanofi-SynthĂ©labo. This drug is also approved by the FDA for use in
metastatic colorectal cancer.
- Bevacizumab (Avastinâ„˘) is a type of intravenous cancer treatment called anti-angiogenic
therapy (a type of therapy to treat cancer that interferes with blood flow to the
tumor, thereby stopping tumor growth, and possibly leading to tumor shrinkage) made by
Genentech Inc. Bevacizumab is approved by the FDA for first line treatment of
metastatic colorectal cancer in combination with other chemotherapy.
- Dasatinib (Sprycelâ„˘) is an oral drug made by BMS, Inc. Dasatinib is approved by the
FDA for the treatment of chronic myeloid leukemia (CML), acute lymphoblastic leukemia
or for patients that are resistant to a medicine called imatinib mesylate (Gleevecâ„˘ ).
Reports of Suspected Eloxatin (Oxaliplatin) Side Effects
Abdominal Pain (18),
Renal Failure Acute (12),
Asthenia (12), more >>