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Eloxatin (Oxaliplatin) - Summary

 
 



WARNING: ANAPHYLACTIC REACTIONS

Anaphylactic reactions to ELOXATIN have been reported, and may occur within minutes of ELOXATIN administration. Epinephrine, corticosteroids, and antihistamines have been employed to alleviate symptoms of anaphylaxis [see Warnings and Precautions].

 

ELOXATIN SUMMARY

ELOXATIN™ (oxaliplatin for injection) is an antineoplastic agent. Oxaliplatin is an organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane (DACH) and with an oxalate ligand as a leaving group.

ELOXATIN, used in combination with infusional 5-FU/LV, is indicated for the treatment of advanced carcinoma of the colon or rectum.


See all Eloxatin indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Eloxatin (Oxaliplatin)

1 in 7 Colorectal Cancers Found in Younger Patients
Source: Medscape Gastroenterology Headlines [2016.02.02]
The prevalence of colorectal cancer is increasing in patients younger than the age for routine screening, and they are presenting with more advanced disease.
Medscape Medical News

1 in 7 colorectal cancer patients diagnosed before recommended screening age
Source: Colorectal Cancer News From Medical News Today [2016.01.25]
Colorectal cancer in younger people linked to more advanced disease but better survival.

Many colorectal cancer patients are younger than the recommended screening age
Source: Colorectal Cancer News From Medical News Today [2016.01.25]
Patients Diagnosed Before Age 50 Often Present with Advanced Disease.In a recent analysis of US data, one in seven colorectal patients was younger than 50 years old, the recommended age to begin...

Colorectal cancer drivers differ between younger and older patients
Source: Colorectal Cancer News From Medical News Today [2016.01.22]
A new study finds that the genetic drivers of colorectal cancer in older patients differ to those of younger patients - and may pave the way to improved treatments.

Link between obesity and increased risk of colorectal cancer revealed
Source: Colorectal Cancer News From Medical News Today [2016.01.18]
Obesity has long been associated with increased risk of colorectal cancer, but the link has never been understood.

more news >>

Published Studies Related to Eloxatin (Oxaliplatin)

Phase III randomized, placebo-controlled, double-blind study of intravenous calcium and magnesium to prevent oxaliplatin-induced sensory neurotoxicity (N08CB/Alliance). [2014]
whether calcium/magnesium decreases oxaliplatin-related neurotoxicity... CONCLUSION: This study does not support using calcium/magnesium to protect

Improved time to treatment failure with an intermittent oxaliplatin strategy: results of CONcePT. [2014]
intended to reduce neurotoxicity and extend the duration of treatment... CONCLUSIONS: An IO dosing schedule had a significant benefit on both TTF and TTP

Phase I drug-interaction study of effects of calcium and magnesium infusions on oxaliplatin pharmacokinetics and acute neurotoxicity in colorectal cancer patients. [2013]
hyperexcitability and acute neurotoxicity symptoms are unclear... CONCLUSIONS: Ca/Mg infusions do not alter the clinical pharmacokinetics of

Primary tumor response to preoperative chemoradiation with or without oxaliplatin in locally advanced rectal cancer: pathologic results of the STAR-01 randomized phase III trial. [2011.07.10]
PURPOSE: To investigate oxaliplatin combined with fluorouracil-based chemoradiotherapy as preoperative treatment for locally advanced rectal cancer... CONCLUSION: Adding oxaliplatin to fluorouracil-based preoperative chemoradiotherapy significantly increases toxicity without affecting primary tumor response. Longer follow-up is needed to assess the impact on efficacy end points.

Intermittent versus continuous oxaliplatin and fluoropyrimidine combination chemotherapy for first-line treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. [2011.07]
BACKGROUND: When cure is impossible, cancer treatment should focus on both length and quality of life. Maximisation of time without toxic effects could be one effective strategy to achieve both of these goals. The COIN trial assessed preplanned treatment holidays in advanced colorectal cancer to achieve this aim... INTERPRETATION: Although this trial did not show non-inferiority of intermittent compared with continuous chemotherapy for advanced colorectal cancer in terms of overall survival, chemotherapy-free intervals remain a treatment option for some patients with advanced colorectal cancer, offering reduced time on chemotherapy, reduced cumulative toxic effects, and improved quality of life. Subgroup analyses suggest that patients with normal baseline platelet counts could gain the benefits of intermittent chemotherapy without detriment in survival, whereas those with raised baseline platelet counts have impaired survival and quality of life with intermittent chemotherapy and should not receive a treatment break. FUNDING: Cancer Research UK. Copyright (c) 2011 Elsevier Ltd. All rights reserved.

more studies >>

Clinical Trials Related to Eloxatin (Oxaliplatin)

Oxaliplatin in Treating Patients With Metastatic Breast Cancer [Active, not recruiting]
This phase 0/II trial studies the effect of carbon C 14 oxaliplatin in tumor tissue and blood and the side effects and how well oxaliplatin works in treating patients with metastatic breast cancer. DNA analysis of tumor tissue and blood samples from patients receiving carbon C 14 oxaliplatin may help doctors predict how well patients will respond to treatment with oxaliplatin. Drugs used in chemotherapy, such as oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.

Safety of ON 01910.Na and Irinotecan or ON 01910.Na and Oxaliplatin in Patients With Hepatoma [Completed]
Studies done in the laboratory have demonstrated beneficial effects of ON 01910. Na, a new, unapproved drug, when it is used in combination either irinotecan and oxaliplatin, two approved, extensively used anti-cancer drugs. In these laboratory studies, mice implanted with cells (Bel-7402 cells) that came from a human tumor were used as a model of liver cancer. In mice that were not treated, the Bel-7402 cells formed very large tumors. In mice that were treated with ON 01910. Na, irinotecan or oxaliplatin alone, growth of tumors was reduced compared to the untreated group. When a combination of ON 01910. Na and irinotecan or of ON 01910. Na and oxaliplatin was used to treat the mice, tumor growth was completely inhibited. Another observation in these studies was that toxicity did not increase when the combinations were used. These results and similar results from other studies support the hypothesis that a combination of ON 01910. Na and irinotecan or of ON 01910. Na and oxaliplatin would be an effective and tolerable treatment for liver and other types of cancer. The primary objective of this phase 1 study is to find out what doses of ON 01910. Na in combination with either irinotecan or oxaliplatin are safe and tolerable in patients with liver and other types of cancer.

Monosialotetrahexosylganglioside for Treatment of Oxaliplatin Induced Neurotoxicity in Gastrointestinal Cancer [Recruiting]
The purpose of this study is to determine whether Monosialotetrahexosylganglioside sodium injection can relieve the neurotoxicity caused by oxaliplatin in GI cancer.

Oxaliplatin, Fludarabine, Cytarabine and Rituximab in Richter's Syndrome, Refractory CLL and PLL [Completed]
Primary Objectives: 1. Determine the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of oxaliplatin in combination with fludarabine, Ara-C and rituximab in patients with Richter's transformation, prolymphocytic leukemia (PLL), or refractory/relapsed B-cell chronic lymphocytic leukemia (CLL). 2. Assess the complete response (CR) and partial response (PR) rate to combination therapy of oxaliplatin, fludarabine, Ara-C and rituximab in patients with Richter's transformation, PLL or refractory/relapsed B-cell CLL. 3. Determine the safety and toxicity profile of combination therapy of oxaliplatin, fludarabine, Ara-C and rituximab in patients with Richter's transformation, PLL or refractory/relapsed B-cell CLL. Secondary Objectives: 1. Determine the duration of response, failure-free survival, and overall survival. 2. Determine the incidence of infections (bacterial, fungal, and viral) in patients with Richter's transformation, prolymphocytic leukemia or refractory/relapsed B-cell CLL treated with rituximab, oxaliplatin, fludarabine and Ara-C; monitor immune parameters such as T cell counts and immunoglobulin levels; and monitor Epstein-Barr virus (EBV) status. 3. Characterize the pharmacodynamics of oxaliplatin in leukemia cells with respect to total adduct formation, cross-link formation and excision deoxyribonucleic acid (DNA) responses. Compare these parameters in cells from the same patient after treatment with oxaliplatin in combination with fludarabine and Ara-C.

Hepatic Arterial Infusion Oxaliplatin, Capecitabine With or Without Bevacizumab [Active, not recruiting]
The goal of this clinical research study is to find the highest tolerable dose of the combination of oxaliplatin and capecitabine with or without bevacizumab that can be given to patients with advanced cancer that has spread to the liver. The safety of these drug combinations will also be studied.

more trials >>

Reports of Suspected Eloxatin (Oxaliplatin) Side Effects

Death (26)Dyspnoea (25)Diarrhoea (23)Nausea (21)Abdominal Pain (18)Vomiting (17)Anaemia (15)Renal Failure Acute (12)Hypertension (12)Asthenia (12)more >>


Page last updated: 2016-02-02

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