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Ella (Ulipristal Acetate) - Summary



The ella (ulipristal acetate) tablet for oral use contains 30 mg of a single active steroid ingredient, ulipristal acetate, a synthetic progesterone agonist/antagonist.

ella is a progesterone agonist/antagonistemergency contraceptive indicated for prevention of pregnancy following unprotected intercourse or a known or suspected contraceptive failure. ella is not intended for routine use as a contraceptive.

See all Ella indications & dosage >>


Media Articles Related to Ella (Ulipristal)

New study indicates laparoscopic hysterectomy with morcellation may be safer than abdominal procedure
Source: Cancer / Oncology News From Medical News Today [2015.03.27]
Decision analysis results published in the American Journal of Obstetrics & GynecologyIn a new study published in the American Journal of Obstetrics & Gynecology, researchers from The University...

Stellate Ganglion Block No Better Than Placebo for PTSD
Source: Medscape NeurologyHeadlines [2015.03.26]
Case reports have raised interest in the treatment in military service members with PTSD, but a randomized controlled trial shows no improvement over a saline injection.
Medscape Medical News

Prostate cancer: Astellas announces new enzalutamide data
Source: Clinical Trials / Drug Trials News From Medical News Today [2015.03.26]
Astellas Pharma Europe Ltd. has announced new data from the Phase 2 TERRAIN trial of enzalutamide compared to bicalutamide in metastatic castration-resistant prostate cancer (CRPC), as well as an...

Cerebellar ataxia can't be cured, but some cases can be treated
Source: Neurology / Neuroscience News From Medical News Today [2015.03.26]
Vitamin E, gluten-free diets among the effective treatments for certain ataxiasNo cures are possible for most patients who suffer debilitating movement disorders called cerebellar ataxias.

Fibroid Morcellation Gets Boost From New Study (CME/CE)
Source: MedPage Today Oncology/Hematology [2015.03.25]
(MedPage Today) -- But procedure was linked to more leiomyosarcoma deaths.

more news >>

Published Studies Related to Ella (Ulipristal)

Ulipristal acetate - safety and pharmacokinetics following multiple doses of 10-50 mg per day. [2013]
N-mono-demethylated metabolite, PGL4002, were investigated in women... CONCLUSION: Daily administration of UPA at therapeutic and

Ulipristal acetate versus levonorgestrel for emergency contraception: a randomised non-inferiority trial and meta-analysis. [2010.02.13]
BACKGROUND: Emergency contraception can prevent unintended pregnancies, but current methods are only effective if used as soon as possible after sexual intercourse and before ovulation. We compared the efficacy and safety of ulipristal acetate with levonorgestrel for emergency contraception... INTERPRETATION: Ulipristal acetate provides women and health-care providers with an effective alternative for emergency contraception that can be used up to 5 days after unprotected sexual intercourse. FUNDING: HRA Pharma. Copyright 2010 Elsevier Ltd. All rights reserved.

Immediate pre-ovulatory administration of 30 mg ulipristal acetate significantly delays follicular rupture. [2010]
mm... CONCLUSIONS: This study demonstrates that UPA can significantly delay follicular

Randomised comparison of the FerX Ella antireflux stent and the ultraflex stent: proton pump inhibitor combination for prevention of post-stent reflux in patients with esophageal carcinoma involving the esophago-gastric junction. [2008.05]
BACKGROUND AND AIM: Metal stents placed across the gastroesophageal junction in patients with malignant dysphagia frequently present with reflux symptoms. We compared an antireflux stent with a standard open stent used in combination with proton pump inhibitor medication... CONCLUSION: The antireflux stent had no demonstrable advantages compared to the combination of standard open stent and proton pump inhibitor medication.

[Selective progesterone receptor modulator (ulipristal acetate--a new option in the pharmacological treatment of uterine fibroids in women]. [Article in Polish] [2013]
Uterine leiomyomata (fibroids) are very common, mostly benign tumors in women of reproductive age... The presented results on the application UPA in the medical treatment of symptomatic uterine fibroids are very promising and gynecologists are given a new treatment option.

more studies >>

Clinical Trials Related to Ella (Ulipristal)

SX ELLA Esophageal Degradable BD Stent System [Recruiting]

CDB-2914 for Abnormal Uterine Bleeding in Premenopausal Women [Not yet recruiting]

- CDB-2914 is a hormone that blocks progesterone, which is necessary for maintaining

pregnancy. In women with fibroid tumors, CDB-2914 shrank the tumors. In many cases, menstrual periods stopped during treatment. Because CDB-2914 decreased or stopped menstrual bleeding in women with fibroids, it may be able to treat abnormal periods in women without fibroids.


- To see whether CDB-2914 can treat abnormal uterine bleeding in premenopausal women.


- Premenopausal women who have abnormal uterine bleeding that is not caused by fibroids.


- Participants will be screened with a physical exam and medical history. They will also

have blood and urine tests. An ultrasound with fluid of the uterus will test for fibroids. Uterine cells will be collected for biopsy.

- For the next three menstrual cycles, participants will take either CDB-2914 or a

placebo. Treatment will be studied with blood tests and symptom diaries.

- At the end of the treatment, participants have three options. They can have surgery at

the Clinical Center or have another 3 months of CDB-2914. The third option is to stop treatment at the Clinical Center.

- Surgery will be either uterine ablation or hysterectomy. Only women older than age 33

may have a hysterectomy. Blood and urine samples will be collected after surgery.

- Both surgery and further treatment participants will have followup exams.

- All participants will have a final followup exam 1 year after stopping treatment.

Study to Evaluate the Safety and Efficacy of Two Contraceptive Vaginal Rings Delivering a Daily Dose of 1500 or 2500 μg of CDB-2914 [Recruiting]

Ulipristal for Endometriosis-related Pelvic Pain [Not yet recruiting]
The aim of this research is to assess the benefit of a medication (ulipristal) for alleviation of symptoms in women with chronic, endometriosis-related pelvic pain.

Clinical Follow-up and Outcomes of Pregnancies Exposed to Ella [Recruiting]
The study is aimed at assessing the clinical follow-up and the outcomes of pregnancies exposed to ella, whether due to failure of the emergency contraception or inadvertent exposure during pregnancy.

more trials >>

Reports of Suspected Ella (Ulipristal) Side Effects

Unintended Pregnancy (4)Maternal Exposure During Pregnancy (3)Drug Ineffective (2)Thirst (2)DRY Mouth (2)Drug Prescribing Error (2)Drug Interaction (1)Pregnancy After Post Coital Contraception (1)Menstrual Disorder (1)Menstruation Irregular (1)more >>

Page last updated: 2015-03-27

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