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Elavil (Amitriptyline) - Summary



ELAVIL (amitriptyline hydrochloride) is an antidepressant drug of the tricyclic type. ELAVIL is an antidepressant with sedative effects. Its mechanism of action in man is not known. It is not a monoamine oxidase inhibitor and it does not act primarily by stimulation of the central nervous system.

For the relief of symptoms of depression. Endogenous depression is more likely to be alleviated than are other depressive states.
See all Elavil indications & dosage >>


Media Articles Related to Elavil (Amitriptyline)

Depression Pictures Slideshow: Tips for Exercise, Diet and Stress Reduction
Source: MedicineNet Stress Specialty [2015.06.26]
Title: Depression Pictures Slideshow: Tips for Exercise, Diet and Stress Reduction
Category: Slideshows
Created: 6/1/2009 12:00:00 AM
Last Editorial Review: 6/26/2015 12:00:00 AM

Vitamin D Improves Depression in Women With Liver Disease
Source: Medscape Psychiatry & Mental Health Headlines [2015.06.25]
Symptoms of depression improve in women with chronic liver disease when treated for vitamin D deficiency.
Medscape Medical News

Depression Pictures Slideshow: Sneaky Depression Triggers as You Age
Source: MedicineNet Depression Specialty [2015.06.24]
Title: Depression Pictures Slideshow: Sneaky Depression Triggers as You Age
Category: Slideshows
Created: 4/2/2012 12:00:00 AM
Last Editorial Review: 6/24/2015 12:00:00 AM

Postpartum Depression Pictures Slideshow: Symptoms, Diagnosis & Treatment
Source: MedicineNet Depression Specialty [2015.06.23]
Title: Postpartum Depression Pictures Slideshow: Symptoms, Diagnosis & Treatment
Category: Slideshows
Created: 2/7/2012 12:00:00 AM
Last Editorial Review: 6/23/2015 12:00:00 AM

PrEP is not linked to greater risk for depression
Source: Depression News From Medical News Today [2015.06.22]
A new paper out of the iPrEx study--a randomized, placebo-controlled trial of daily oral HIV pre-exposure prophylaxis (PrEP) in men and transgender women who have sex with men--reported no link...

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Published Studies Related to Elavil (Amitriptyline)

Effect of Minocycline on Lumbar Radicular Neuropathic Pain: A Randomized, Placebo-controlled, Double-blind Clinical Trial with Amitriptyline as a Comparator. [2014]
the treatment of neuropathic pain... CONCLUSIONS:: Although both groups differed from placebo, their effect size was

A phase III randomized, placebo-controlled study of topical amitriptyline and ketamine for chemotherapy-induced peripheral neuropathy (CIPN): a University of Rochester CCOP study of 462 cancer survivors. [2014]
efficacy of 2% ketamine plus 4% amitriptyline (KA) cream for reducing CIPN... CONCLUSIONS: This study suggests that KA cream does not decrease CIPN symptoms in

A meta-analysis of the therapeutic effects of amitriptyline for treating irritable bowel syndrome. [2013]
controlled trials... CONCLUSION: It was thus concluded that amitriptyline exhibits a clinically and

Clinical anesthetic effectiveness of intraoral mucoadhesive tablets of amitriptyline in healthy volunteers. [2013]
amitriptyline... CONCLUSIONS: To our knowledge, the present study represents an initial step

A comparative efficacy of amitriptyline, gabapentin, and pregabalin in neuropathic cancer pain: a prospective randomized double-blind placebo-controlled study. [2012]
Neuropathic pain is difficult to diagnose and difficult to treat with certainty. So the aim of the study was to evaluate comparative clinical efficacy of pregabaline with amitriptyline and gabapentin in neuropathic cancer pain... There was statistically and clinically significant morphine sparing effect of pregabaline in relieving neuropathic cancer pain and neuropathic symptoms as compared to other antineuropathic drugs.

more studies >>

Clinical Trials Related to Elavil (Amitriptyline)

Low Doses Amitriptyline & Chronic Neck Pain [Recruiting]
The objective of this prospective randomized and controlled study is to evaluate the efficacy and safety of low dose of amitriptyline (5 mg) in the management of chronic neck pain.

Combining N-of-1 Trials to Assess Fibromyalgia Treatments [Completed]
This study will compare the effectiveness of combination therapy with the drugs amitriptyline and fluoxetine (AM+FL) and amitriptyline (AM) alone in the treatment of people with fibromyalgia. Doctors will treat each study participant with both AM + FL and AM alone for 6 weeks at a time. The study uses a method that combines results from treatment of individual patients to assess overall treatment effectiveness and help individual patients and their physicians with their treatment decisions. This study will also help compare the results of community-based studies (studies involving private doctors) and studies based at clinical research centers.

Trial of Amitriptyline for Chronic Oral Food Refusal in Children 9 Months to 4 Years of Age [Recruiting]
Gastrojejunal (G-J) feeding tubes are placed in infants and children who refuse to eat or are unable to eat enough to have normal growth. Although often intended as temporary short-term solutions to medical complications, feeding tubes can become a permanent method for eating.

While tube feeding routinely saves the lives of children who have long term food refusal, continuation of tube feeding can be hard for patients, caregivers, and families. At the current time there are few treatments for helping children move from tube to oral feeding. Some patients may be treated with the help of inpatient programs such as a combination of medical and behavioral techniques to train children to eat orally. These programs typically require hospital stays of 2-4 months.

By doing the current study the investigators hope to learn if the investigational drug amitriptyline is helpful in moving children from tube to oral feeding, and to look at whether or not the treatment of pain helps with this transition.

Anti-Inflammatory Pulmonal Therapy of CF-Patients With Amitriptyline and Placebo [Completed]
Our data indicate that the CFTR-molecule functions as a transporter for sphingosine-1-phosphate and sphingosine or regulates the uptake of these sphingolipids by epithelial cells. The disturbed uptake of sphingosine and sphingosine-1-phosphate over the cell membrane results in an accumulation of ceramide in the cell membrane, which finally triggers a pro-inflammatory and pro-apoptotic status in the respiratory tract of cystic fibrosis patients. Amitriptyline reduces the cera-mide levels in the lung tissue, normalises the activity of cytokines and prevents constitutive cell death of epithelial cells observed in CFTR-deficient mice. Most important, amitriptyline prevents pulmonary infections of CFTR-deficient mice with P. aeruginosa. These effects of amitriptyline may result in an improved lung function of cystic fibrosis patients.

Comparative Efficacy and Tolerability of Quetiapine XR and Amitriptyline in the Treatment of Fibromyalgia [Recruiting]
Quetiapine, a second generation antipsychotic, has shown beneficial activity on fibromyalgia symptomatology, administered as add-on treatment, in a sample of 35 patients. The purpose of the present study is to compare, in a controlled setting, the efficacy and the tolerability of quetiapine extended release with amitriptyline in the treatment of patients with fibromyalgia

more trials >>

Reports of Suspected Elavil (Amitriptyline) Side Effects

Drug Ineffective (14)Drug Hypersensitivity (14)Weight Increased (13)Disturbance in Attention (13)Pain (11)Agitation (10)Rash (10)Fatigue (9)Depression (9)Toxicity TO Various Agents (9)more >>


Based on a total of 23 ratings/reviews, Elavil has an overall score of 7.52. The effectiveness score is 8.43 and the side effect score is 7.22. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.

Elavil review by 56 year old female patient

Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
Treatment Info
Condition / reason:   Depression
Dosage & duration:   25 mg. taken daily for the period of 12 years
Other conditions:   Sleep problems
Other drugs taken:   Erythrom.
Reported Results
Benefits:   Although this drug was originally prescribed for depression, it helped with sleeplessness. Therefore, I have continued to take it for that alone. While I still on occasion have problems falling asleep, I find I can combine it with Melatonin or Valerian. In 12 years, I haven't had to increase the elavil dosage.
Side effects:   None.
Comments:   One a day, taken about an hour before bedtime.


Elavil review by 51 year old female patient

Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
Treatment Info
Condition / reason:   sleep
Dosage & duration:   35mg taken once a day for the period of 22years
Other conditions:   anxiety, shy, but overal healthy
Other drugs taken:   larozepam took for 5-6 years, discontinued
Reported Results
Benefits:   helps me fall asleep and stay asleep
Side effects:   difficult to get up, tiredness in the morning, light sensitivity, constipation
Comments:   i have been take amitriptyline for the last 22 years, without too serious side effects. i never miss a dose- if by some reason i dont have it - i will never be able to fall asleep at all. I started on 10mg but now i am taking 35mg, it helps.


Elavil review by 61 year old female patient

Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   Severe Side Effects
Treatment Info
Condition / reason:   insomnia
Dosage & duration:   150 mg taken once for the period of once
Other conditions:   sarcoidosis
Other drugs taken:   lisinopril, theophylline, cartia, premarin
Reported Results
Benefits:   Highly effective for sleeping.
Side effects:   Slept for 3 days. Very disoriented and groggy!
Comments:   not exactly what I had in mind. I wake up during the night at 2 or 3 or 4 am and am unable to go back to sleep, I wanted the ability to sleep through the night. But I did not want to sleep for 3 days! I think maybe the initial dose was too high. I only took one tablet and never took another one.

See all Elavil reviews / ratings >>

Page last updated: 2015-06-26

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