DOSAGE AND ADMINISTRATION
Initiate Effient treatment as a single 60 mg oral loading dose and then continue at 10 mg orally once daily. Patients taking Effient should also take aspirin (75 mg to 325 mg) daily [see Drug Interactions and Clinical Pharmacology ]. Effient may be administered with or without food [see Clinical Pharmacology and Clinical Studies (14)].
Dosing in Low Weight Patients
Compared to patients weighing ≥ 60 kg, patients weighing < 60 kg have an increased exposure to the active metabolite of prasugrel and an increased risk of bleeding on a 10 mg once daily maintenance dose. Consider lowering the maintenance dose to 5 mg in patients < 60 kg. The effectiveness and safety of the 5 mg dose have not been prospectively studied.
DOSAGE FORMS AND STRENGTHS
Effient 5 mg is a yellow, elongated hexagonal, film-coated, non-scored tablet debossed with "5 MG" on one side and "4760" on the other side.
Effient 10 mg is a beige, elongated hexagonal, film-coated, non-scored tablet debossed with "10 MG" on one side and with "4759" on the other side.