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Ecotrin (Aspirin Enteric Coated) - Summary

 
 



ECOTRIN SUMMARY

Ecotrin enteric coated aspirin (acetylsalicylic acid) tablets available in 81mg, 325mg and 500 mg tablets for oral administration.

Vascular Indications (Ischemic Stroke, TIA, Acute MI, Prevention of Recurrent MI, Unstable Angina Pectoris, and Chronic Stable Angina Pectoris): Aspirin is indicated to: (1) Reduce the combined risk of death and nonfatal stroke in patients who have had ischemic stroke or transient ischemia of the brain due to fibrin platelet emboli, (2) reduce the risk of vascular mortality in patients with a suspected acute MI, (3) reduce the combined risk of death and nonfatal MI in patients with a previous MI or unstable angina pectoris, and (4) reduce the combined risk of MI and sudden death in patients with chronic stable angina pectoris.

Revascularization Procedures (Coronary Artery Bypass Graft (CABG), Percutaneous Transluminal Coronary Angioplasty (PTCA), and Carotid Endarterectomy): Aspirin is indicated in patients who have undergone revascularization procedures (i.e., CABG, PTCA, or carotid endarterectomy) when there is a preexisting condition for which aspirin is already indicated.

Rheumatologic Disease Indications (Rheumatoid Arthritis, Juvenile Rheumatoid Arthritis, Spondyloarthropathies, Osteoarthritis, and the Arthritis and Pleurisy of Systemic Lupus Erythematosus (SLE)): Aspirin is indicated for the relief of the signs and symptoms of rheumatoid arthritis, juvenile rheumatoid arthritis, osteoarthritis, spondyloarthropathies, and arthritis and pleurisy associated with SLE.


See all Ecotrin indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Ecotrin (Aspirin)

Aspirin, NSAIDs linked to reduced risk of colorectal cancer
Source: Cancer / Oncology News From Medical News Today [2015.08.25]
New research finds continuous long-term use of aspirin and nonsteroidal anti-inflammatory drugs may be associated with lower risk of colorectal cancer.

Long-term NSAID use may reduce CRC risk; Corticosteroid injections; Aspirin study
Source: Cardiovascular / Cardiology News From Medical News Today [2015.08.25]
1. Long-term NSAID use associated with reduced colorectal cancer riskLong-term, continuous use of low-dose aspirin and nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with...

Low-Dose Aspirin, Other Painkillers May Lower Colon Cancer Risk
Source: MedicineNet Cancer Specialty [2015.08.25]
Title: Low-Dose Aspirin, Other Painkillers May Lower Colon Cancer Risk
Category: Health News
Created: 8/24/2015 12:00:00 AM
Last Editorial Review: 8/25/2015 12:00:00 AM

Nonaspirin NSAIDs Match Aspirin on Cancer Protection
Source: Medscape Gastroenterology Headlines [2015.08.24]
Nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) offer a degree of protection against colorectal cancer comparable to aspirin.
Medscape Medical News

Aspirin could reduce cancer risk of overweight people
Source: Colorectal Cancer News From Medical News Today [2015.08.18]
New research suggests that a daily dose of aspirin counteracted the increased risk of cancer associated with a higher body mass index.

more news >>

Published Studies Related to Ecotrin (Aspirin)

Initial 3-Weeks' Apixaban Versus Dual-Antiplatelet Therapy (Clopidogrel and Aspirin) Followed by Clopidogrel Alone in High-Risk Patients with Acute Non-Disabling Cerebrovascular Events (ADANCE): Study Protocol for a Randomized Controlled Trial. [2014]
BACKGROUND: Nondisabling cerebrovascular events represent the largest group of cerebrovascular disease with a high risk of recurrent stroke. A recent trial demonstrated that dual-antiplatelet therapy (clopidogrel and aspirin), compared with aspirin monotherapy, reduced the risk of recurrent stroke and was not associated with increased risk of hemorrhagic events...

Augmentation of citalopram with aspirin for treating major depressive disorder, a double blind randomized placebo controlled clinical trial. [2014]
There are contradictory reports about the association of cytokines levels and major depressive disorder and the possible therapeutic role of aspirin for treating major depressive disorder (MDD). A clinical sample of adult out-patients with MDD was recruited...

Association of aspirin dose and vorapaxar safety and efficacy in patients with non-ST-segment elevation acute coronary syndrome (from the TRACER Trial). [2014]
Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRACER) trial compared vorapaxar and placebo in 12,944 high-risk patients with non-ST-segment elevation acute coronary syndrome. We explored aspirin (ASA) use and its association with outcomes... Although formal statistical testing did not reveal heterogeneity in vorapaxar's effect across dose subgroups, consistent trends support use of low-dose ASA with other antiplatelet therapies.

Apixaban vs. warfarin with concomitant aspirin in patients with atrial fibrillation: insights from the ARISTOTLE trial. [2014]
CONCLUSION: Apixaban had similar beneficial effects on stroke or systemic

Aspirin for the prevention of recurrent venous thromboembolism: the INSPIRE collaboration. [2014]
CONCLUSIONS: Aspirin after anticoagulant treatment reduces the overall risk of

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Clinical Trials Related to Ecotrin (Aspirin)

Therapeutic Control of Aspirin-Exacerbated Respiratory Disease (Aspirin) [Recruiting]
The investigators are doing this research study to find out if giving a drug called prasugrel, which is used to prevent blood clots, can reduce reactions to aspirin in people with aspirin exacerbated respiratory disease (AERD), and to learn why taking aspirin every day can work as a treatment for people with AERD. People with AERD have symptoms of asthma, severe runny nose, polyps in the nose, and develop allergic reactions if they take medications like aspirin. People with AERD can be desensitized to aspirin in order to be able to safely use it daily, but the investigators do not know if prasugrel may prevent reactions to aspirin and provide a safer way for people with AERD to tolerate aspirin. The investigators also want to understand what is different about the cells and urine from subjects who have AERD, in comparison to subjects who have asthma but do not have AERD and subjects who have allergic rhinitis but do not have asthma. Lastly, the investigators want to understand how aspirin acts differently in subjects who have AERD, in comparison to subjects who have asthma but do not have AERD.

Effects of Different Doses of Aspirin on Pathophysiological Markers in Type 2 Diabetes [Completed]
This study was set up to assess the effects of different doses of aspirin when compared with placebo (dummy drug), used sequentially over a 2 week study period with a 2 week wash-out (rest period) in between, in people with type-2 diabetes and high cardiovascular risk. Specifically, its effects on different factors which are thought to contribute to diabetes such as insulin resistance (body's ability to effectively use insulin), dysglycaemia (excess glucose in the blood), oxidative stress (effects from accumulation of by-products of metabolism), endothelial function (function of lining of blood vessels) and inflammation were studied.

Effect of Aspirin at the Acute Phase of Cerebral Ischemic Event. [Recruiting]
Aspirin is the only anti-platelet medication used at the acute phase of ischemic stroke. The investigators would like to study laboratory effect of the first oral 300 mg dose of aspirin, given at hospital, after an ischemic event. The principal hypothesis is that platelet activity would be able to recover during this day and could lead to ischemic recurrences. Two blood samples are accomplished. The first 2 hours after aspirin intake and the second 23 hours after. Photometric aggregometry are performed with arachidonic acid and collagen induced platelet aggregation, measure of thromboxan B2 levels and reticular platelets count.

The Effects of Omega-3 Fatty Acids on Aspirin Resistance [Completed]

Aspirin Supplementation for Pregnancy Indicated Risk Reduction In Nulliparas (ASPIRIN) [Not yet recruiting]
Available data suggest that Low Dose Aspirin may be a safe, widely available and inexpensive intervention that may significantly reduce the risk of preterm birth. However, this possibility needs to be proven in a properly designed randomized controlled trial (RCT) with preterm birth as the primary outcome. Such a clinical trial in a racially, ethnically and geographically diverse population could best be accomplished by the established infrastructure of the Global Network for Women's and Children's Health Research (GN).

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PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 7 ratings/reviews, Ecotrin has an overall score of 7.43. The effectiveness score is 8 and the side effect score is 8.57. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Ecotrin review by 45 year old male patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   headache
Dosage & duration:   325 mg taken once for the period of 1 day
Other conditions:   nonce
Other drugs taken:   none
  
Reported Results
Benefits:   Pain and pressure in front temporal lobes was reduced 50% within 2 hours of initial treament. Within 4 hours an overall 80% reduction in symptom severity.
Side effects:   No side effects were noticed over a 72 hour period following initial treament taken in the evening.
Comments:   One 325 mg tablet taken with 12 oz glass of water in evening.

 

Ecotrin review by 15 year old male patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   pain
Dosage & duration:   300mg taken once for the period of one week
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   The treatment benefits from taking 300 milligrams of Bayer aspirin for headache pain were decreased pain. The positive effects for diminishing the pain were noticed in about half an hour to a full hour or so. The headache pain was nearly and sometimes even completely relieved with the Bayer. But, after a few hours or so, the pain would come back and I would have to take more of the drug.
Side effects:   No side effects were noticed.
Comments:   The treatment would start as soon as pain was noticed. 300 milligrams of aspirin was taken for every headache episode.

 

Ecotrin review by 69 year old male patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   CAD
Dosage & duration:   75 mg. taken orally, once daily, post cibos. for the period of 2 years
Other conditions:   Hypertension.
Other drugs taken:   Pantoprazol, Metoprolol, Clopidogrel, Amlodipine, Atorvastatin, Ezetimibe, Vitamin-E
  
Reported Results
Benefits:   I am in reasonable good health. I am non-diabetic, Serum Glucose level is normal [Fasting=100, PP=104]. I am a non-smoker since 7th March, 1975 [prior to that I smoked 60 cigarettes a day for17 years].My Blood lipids are within normal limits [Total Cholesterol=108, HDL=36, LDL=62,VLDL=10.HDL is a bit low [36] but TC:HDL ratio=3.00 and appears to be within favourable range of low risk of "up to 4.5". Kidney function is also within normal range. Liver Function is also normal except SGPT=46. Haemogram is normal. Hb%=15.1. Serum Prostate Specific Antigen=0.75, well within nornal range.
Side effects:   I developed severe epigastric pain, relieved by liquid antacids in June 2006. I had to bear with it till Gastroscopy confirmed Duodenal Ulcer and I had to discontinue Aspirin since December 2006. My HDL is 36. SGPT is slightly raised since 2004. I developed severe Hypothyroidism in July 2007 and have to take Thyroxine Sodium since confirmation of the diagnosis. Echocardiography reports Atherosclerotic AV and AO root. USG reports Fatty infiltration of Pancreas and Partially Contracted GB but I have no complain. I am having occasional pain in joints and they are being cured without any additional drug
Comments:   In April 2005, I felt some mild discomfort in my chest or precordium, which was did not simulate any cardiac pain, ECG was within normal limit, even then I was admitted in a Hospital. Trop-T test indicated Myocardial Infarction. Angiography revealed 90% block in Left Posterior Circumflex Artery, PTCA was done followd by non-drug-elluting stent.

See all Ecotrin reviews / ratings >>

Page last updated: 2015-08-25

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