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Ecotrin (Aspirin Enteric Coated) - Summary

 
 



ECOTRIN SUMMARY

Ecotrin enteric coated aspirin (acetylsalicylic acid) tablets available in 81mg, 325mg and 500 mg tablets for oral administration.

Vascular Indications (Ischemic Stroke, TIA, Acute MI, Prevention of Recurrent MI, Unstable Angina Pectoris, and Chronic Stable Angina Pectoris): Aspirin is indicated to: (1) Reduce the combined risk of death and nonfatal stroke in patients who have had ischemic stroke or transient ischemia of the brain due to fibrin platelet emboli, (2) reduce the risk of vascular mortality in patients with a suspected acute MI, (3) reduce the combined risk of death and nonfatal MI in patients with a previous MI or unstable angina pectoris, and (4) reduce the combined risk of MI and sudden death in patients with chronic stable angina pectoris.

Revascularization Procedures (Coronary Artery Bypass Graft (CABG), Percutaneous Transluminal Coronary Angioplasty (PTCA), and Carotid Endarterectomy): Aspirin is indicated in patients who have undergone revascularization procedures (i.e., CABG, PTCA, or carotid endarterectomy) when there is a preexisting condition for which aspirin is already indicated.

Rheumatologic Disease Indications (Rheumatoid Arthritis, Juvenile Rheumatoid Arthritis, Spondyloarthropathies, Osteoarthritis, and the Arthritis and Pleurisy of Systemic Lupus Erythematosus (SLE)): Aspirin is indicated for the relief of the signs and symptoms of rheumatoid arthritis, juvenile rheumatoid arthritis, osteoarthritis, spondyloarthropathies, and arthritis and pleurisy associated with SLE.


See all Ecotrin indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Ecotrin (Aspirin)

US Patients Commonly Prescribed High-Dose Aspirin After MI
Source: theheart.org | Medscape Cardiology Headlines [2014.08.14]
Following hospitalization for STEMI or non-STEMI, most patients in the US are sent home with high-dose aspirin, a recent study reports, contrary to newer guidelines touting low-dose aspirin.
Heartwire

Aspirin 'halves breast cancer recurrence in overweight women'
Source: Breast Cancer News From Medical News Today [2014.08.14]
Aspirin is known to have protective effects against some cancers. Now, a new study suggests that, in breast cancer patients, these effects may be mediated by weight.

High-Dose Aspirin After MI Still Common (CME/CE)
Source: MedPage Today Endocrinology [2014.08.13]
(MedPage Today) -- Many patients with myocardial infarction (MI) were discharged from U.S. hospitals on high-dose aspirin, even if they were at high risk for bleeding, researchers reported.

Doctors May Miss Out on Recommending Aspirin Therapy
Source: MedicineNet Cancer Specialty [2014.08.11]
Title: Doctors May Miss Out on Recommending Aspirin Therapy
Category: Health News
Created: 8/8/2014 4:35:00 PM
Last Editorial Review: 8/11/2014 12:00:00 AM

Many doctors don't recommend baby aspirin, despite guidelines
Source: Cardiovascular / Cardiology News From Medical News Today [2014.08.08]
A majority of middle-aged men and women eligible to take aspirin to prevent heart attack and stroke do not recall their doctors ever telling them to do so, according to a University of Rochester...

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Published Studies Related to Ecotrin (Aspirin)

A combination of esomeprazole and aspirin reduces tissue concentrations of prostaglandin E(2) in patients with Barrett's esophagus. [2012]
CONCLUSIONS: In combination with esomeprazole, short-term administration of

Aspirin for the prevention of cognitive decline in the elderly: rationale and design of a neuro-vascular imaging study (ENVIS-ion). [2012]
BACKGROUND: This paper describes the rationale and design of the ENVIS-ion Study, which aims to determine whether low-dose aspirin reduces the development of white matter hyper-intense (WMH) lesions and silent brain infarction (SBI). Additional aims include determining whether a) changes in retinal vascular imaging (RVI) parameters parallel changes in brain magnetic resonance imaging (MRI); b) changes in RVI parameters are observed with aspirin therapy; c) baseline cognitive function correlates with MRI and RVI parameters; d) changes in cognitive function correlate with changes in brain MRI and RVI and e) whether factors such as age, gender or blood pressure influence the above associations...

Evaluation of onset of pain relief from micronized aspirin in a dental pain model. [2012]
A new formulation of a micronized acetylsalicylic acid swallowable tablet with an effervescent component (FR-aspirin) was evaluated in two independent studies using the dental impaction pain model. These clinical studies were performed to confirm the results of preclinical dissolution studies and human pharmacokinetic studies, which indicated an improved onset of analgesia without compromising duration of effect or safety...

Aspirin for primary prevention of vascular events in women: individualized prediction of treatment effects. [2011.12]
Aims To identify women who benefit from aspirin 100 mg on alternate days for primary prevention of vascular events by using treatment effect prediction based on individual patient characteristics. Methods and results Randomized controlled trial data from the Women's Health Study were used to predict treatment effects for individual women in terms of absolute risk reduction for major cardiovascular events (i.e...

Impact of preoperative maintenance or interruption of aspirin on thrombotic and bleeding events after elective non-cardiac surgery: the multicentre, randomized, blinded, placebo-controlled, STRATAGEM trial. [2011.12]
BACKGROUND: /st> Patients receiving anti-platelet agents for secondary cardiovascular prevention frequently require non-cardiac surgery. A substantial proportion of these patients have their anti-platelet drug discontinued before operation; however, there is uncertainty about the impact of this practice. The aim of this study was to compare the effect of maintenance or interruption of aspirin before surgery, in terms of major thrombotic and bleeding events... CONCLUSIONS: /st> In these at-risk patients undergoing elective non-cardiac surgery, we did not find any difference in terms of occurrence of major thrombotic or bleeding events between preoperative maintenance or interruption of aspirin.ClinicalTrials.gov identifier. NCT00190307.

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Clinical Trials Related to Ecotrin (Aspirin)

Study to Evaluate the Incidence of Gastric Ulcers Following Administration of Either PA32540 or Enteric Coated Aspirin 325 mg in Subjects Who Are at Risk for Developing Aspirin-Associated Ulcers [Recruiting]
Primary: To demonstrate that PA32540 causes fewer gastric ulcers in subjects at risk for developing aspirin-associated gastric ulcers compared to enteric coated (EC) aspirin 325 mg.

A Study to Evaluate the Incidence of Gastric Ulcers Following Administration of Either PA32540 or Enteric Coated Aspirin 325 mg in Subjects Who Are at Risk for Developing Aspirin-Associated Ulcers [Recruiting]
Primary: To demonstrate that PA32540 causes fewer gastric ulcers in subjects at risk for developing aspirin-associated gastric ulcers compared to enteric coated (EC) aspirin 325 mg.

Acetylsalicylic Acid Combined With Pseudoephedrine in Common Cold [Recruiting]

Evaluate Relative Bioavailability of PA32540 (Asa/Omeprazole), Its Aspirin Component, and EcotrinŽ in Healthy Volunteers [Completed]
Study to determine a single dose bioavailablity of PA32540 is similar to EC aspirin 325 mg with respect to salicylic acid.

Therapeutic Control of Aspirin-Exacerbated Respiratory Disease (Aspirin) [Recruiting]
The investigators are doing this research study to find out if giving a drug called prasugrel, which is used to prevent blood clots, can reduce reactions to aspirin in people with aspirin exacerbated respiratory disease (AERD), and to learn why taking aspirin every day can work as a treatment for people with AERD. People with AERD have symptoms of asthma, severe runny nose, polyps in the nose, and develop allergic reactions if they take medications like aspirin.

People with AERD can be desensitized to aspirin in order to be able to safely use it daily, but the investigators do not know if prasugrel may prevent reactions to aspirin and provide a safer way for people with AERD to tolerate aspirin.

The investigators also want to understand what is different about the cells and urine from subjects who have AERD, in comparison to subjects who have asthma but do not have AERD and subjects who have allergic rhinitis but do not have asthma. Lastly, the investigators want to understand how aspirin acts differently in subjects who have AERD, in comparison to subjects who have asthma but do not have AERD.

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PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 7 ratings/reviews, Ecotrin has an overall score of 7.43. The effectiveness score is 8 and the side effect score is 8.57. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Ecotrin review by 45 year old male patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   headache
Dosage & duration:   325 mg taken once for the period of 1 day
Other conditions:   nonce
Other drugs taken:   none
  
Reported Results
Benefits:   Pain and pressure in front temporal lobes was reduced 50% within 2 hours of initial treament. Within 4 hours an overall 80% reduction in symptom severity.
Side effects:   No side effects were noticed over a 72 hour period following initial treament taken in the evening.
Comments:   One 325 mg tablet taken with 12 oz glass of water in evening.

 

Ecotrin review by 15 year old male patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   pain
Dosage & duration:   300mg taken once for the period of one week
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   The treatment benefits from taking 300 milligrams of Bayer aspirin for headache pain were decreased pain. The positive effects for diminishing the pain were noticed in about half an hour to a full hour or so. The headache pain was nearly and sometimes even completely relieved with the Bayer. But, after a few hours or so, the pain would come back and I would have to take more of the drug.
Side effects:   No side effects were noticed.
Comments:   The treatment would start as soon as pain was noticed. 300 milligrams of aspirin was taken for every headache episode.

 

Ecotrin review by 69 year old male patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   CAD
Dosage & duration:   75 mg. taken orally, once daily, post cibos. for the period of 2 years
Other conditions:   Hypertension.
Other drugs taken:   Pantoprazol, Metoprolol, Clopidogrel, Amlodipine, Atorvastatin, Ezetimibe, Vitamin-E
  
Reported Results
Benefits:   I am in reasonable good health. I am non-diabetic, Serum Glucose level is normal [Fasting=100, PP=104]. I am a non-smoker since 7th March, 1975 [prior to that I smoked 60 cigarettes a day for17 years].My Blood lipids are within normal limits [Total Cholesterol=108, HDL=36, LDL=62,VLDL=10.HDL is a bit low [36] but TC:HDL ratio=3.00 and appears to be within favourable range of low risk of "up to 4.5". Kidney function is also within normal range. Liver Function is also normal except SGPT=46. Haemogram is normal. Hb%=15.1. Serum Prostate Specific Antigen=0.75, well within nornal range.
Side effects:   I developed severe epigastric pain, relieved by liquid antacids in June 2006. I had to bear with it till Gastroscopy confirmed Duodenal Ulcer and I had to discontinue Aspirin since December 2006. My HDL is 36. SGPT is slightly raised since 2004. I developed severe Hypothyroidism in July 2007 and have to take Thyroxine Sodium since confirmation of the diagnosis. Echocardiography reports Atherosclerotic AV and AO root. USG reports Fatty infiltration of Pancreas and Partially Contracted GB but I have no complain. I am having occasional pain in joints and they are being cured without any additional drug
Comments:   In April 2005, I felt some mild discomfort in my chest or precordium, which was did not simulate any cardiac pain, ECG was within normal limit, even then I was admitted in a Hospital. Trop-T test indicated Myocardial Infarction. Angiography revealed 90% block in Left Posterior Circumflex Artery, PTCA was done followd by non-drug-elluting stent.

See all Ecotrin reviews / ratings >>

Page last updated: 2014-08-14

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