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Ecotrin (Aspirin Enteric Coated) - Summary

 
 



ECOTRIN SUMMARY

Ecotrin enteric coated aspirin (acetylsalicylic acid) tablets available in 81mg, 325mg and 500 mg tablets for oral administration.

Vascular Indications (Ischemic Stroke, TIA, Acute MI, Prevention of Recurrent MI, Unstable Angina Pectoris, and Chronic Stable Angina Pectoris): Aspirin is indicated to: (1) Reduce the combined risk of death and nonfatal stroke in patients who have had ischemic stroke or transient ischemia of the brain due to fibrin platelet emboli, (2) reduce the risk of vascular mortality in patients with a suspected acute MI, (3) reduce the combined risk of death and nonfatal MI in patients with a previous MI or unstable angina pectoris, and (4) reduce the combined risk of MI and sudden death in patients with chronic stable angina pectoris.

Revascularization Procedures (Coronary Artery Bypass Graft (CABG), Percutaneous Transluminal Coronary Angioplasty (PTCA), and Carotid Endarterectomy): Aspirin is indicated in patients who have undergone revascularization procedures (i.e., CABG, PTCA, or carotid endarterectomy) when there is a preexisting condition for which aspirin is already indicated.

Rheumatologic Disease Indications (Rheumatoid Arthritis, Juvenile Rheumatoid Arthritis, Spondyloarthropathies, Osteoarthritis, and the Arthritis and Pleurisy of Systemic Lupus Erythematosus (SLE)): Aspirin is indicated for the relief of the signs and symptoms of rheumatoid arthritis, juvenile rheumatoid arthritis, osteoarthritis, spondyloarthropathies, and arthritis and pleurisy associated with SLE.


See all Ecotrin indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Ecotrin (Aspirin)

Study Casts Doubt on Low-Dose Aspirin for Women Under 65
Source: MedicineNet Heart Attack Specialty [2014.12.05]
Title: Study Casts Doubt on Low-Dose Aspirin for Women Under 65
Category: Health News
Created: 12/4/2014 12:00:00 AM
Last Editorial Review: 12/5/2014 12:00:00 AM

Long-Term Use of Aspirin Plus Blood Thinner Is Safe: Study
Source: MedicineNet Clinical Trials Specialty [2014.11.18]
Title: Long-Term Use of Aspirin Plus Blood Thinner Is Safe: Study
Category: Health News
Created: 11/17/2014 12:00:00 AM
Last Editorial Review: 11/18/2014 12:00:00 AM

Daily Aspirin Fails to Help Older Hearts in Japanese Study
Source: MedicineNet Clinical Trials Specialty [2014.11.18]
Title: Daily Aspirin Fails to Help Older Hearts in Japanese Study
Category: Health News
Created: 11/17/2014 12:00:00 AM
Last Editorial Review: 11/18/2014 12:00:00 AM

Daily Aspirin May Help Prevent Cancer, Study Shows
Source: MedicineNet Esophageal Cancer Specialty [2014.08.06]
Title: Daily Aspirin May Help Prevent Cancer, Study Shows
Category: Health News
Created: 8/6/2014 9:36:00 AM
Last Editorial Review: 8/6/2014 12:00:00 AM

Aspirin may not provide optimum anti-coagulation for all patients
Source: The Doctors Lounge - Hematology
Evidence is growing that some people will not respond to the anti-coagulant action of aspirin despite its regular intake.

more news >>

Published Studies Related to Ecotrin (Aspirin)

Initial 3-Weeks' Apixaban Versus Dual-Antiplatelet Therapy (Clopidogrel and Aspirin) Followed by Clopidogrel Alone in High-Risk Patients with Acute Non-Disabling Cerebrovascular Events (ADANCE): Study Protocol for a Randomized Controlled Trial. [2014]
BACKGROUND: Nondisabling cerebrovascular events represent the largest group of cerebrovascular disease with a high risk of recurrent stroke. A recent trial demonstrated that dual-antiplatelet therapy (clopidogrel and aspirin), compared with aspirin monotherapy, reduced the risk of recurrent stroke and was not associated with increased risk of hemorrhagic events...

Augmentation of citalopram with aspirin for treating major depressive disorder, a double blind randomized placebo controlled clinical trial. [2014]
There are contradictory reports about the association of cytokines levels and major depressive disorder and the possible therapeutic role of aspirin for treating major depressive disorder (MDD). A clinical sample of adult out-patients with MDD was recruited...

Association of aspirin dose and vorapaxar safety and efficacy in patients with non-ST-segment elevation acute coronary syndrome (from the TRACER Trial). [2014]
Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRACER) trial compared vorapaxar and placebo in 12,944 high-risk patients with non-ST-segment elevation acute coronary syndrome. We explored aspirin (ASA) use and its association with outcomes... Although formal statistical testing did not reveal heterogeneity in vorapaxar's effect across dose subgroups, consistent trends support use of low-dose ASA with other antiplatelet therapies.

Apixaban vs. warfarin with concomitant aspirin in patients with atrial fibrillation: insights from the ARISTOTLE trial. [2014]
CONCLUSION: Apixaban had similar beneficial effects on stroke or systemic

Study design of ASPirin in Reducing Events in the Elderly (ASPREE): a randomized, controlled trial. [2013]
Cost-effective strategies to maintain healthy active lifestyle in aging populations are required to address the global burden of age-related diseases. ASPREE will examine whether the potential primary prevention benefits of low dose aspirin outweigh the risks in older healthy individuals.

more studies >>

Clinical Trials Related to Ecotrin (Aspirin)

Study to Evaluate the Incidence of Gastric Ulcers Following Administration of Either PA32540 or Enteric Coated Aspirin 325 mg in Subjects Who Are at Risk for Developing Aspirin-Associated Ulcers [Recruiting]
Primary: To demonstrate that PA32540 causes fewer gastric ulcers in subjects at risk for developing aspirin-associated gastric ulcers compared to enteric coated (EC) aspirin 325 mg.

A Study to Evaluate the Incidence of Gastric Ulcers Following Administration of Either PA32540 or Enteric Coated Aspirin 325 mg in Subjects Who Are at Risk for Developing Aspirin-Associated Ulcers [Recruiting]
Primary: To demonstrate that PA32540 causes fewer gastric ulcers in subjects at risk for developing aspirin-associated gastric ulcers compared to enteric coated (EC) aspirin 325 mg.

Acetylsalicylic Acid Combined With Pseudoephedrine in Common Cold [Recruiting]

Evaluate Relative Bioavailability of PA32540 (Asa/Omeprazole), Its Aspirin Component, and EcotrinŽ in Healthy Volunteers [Completed]
Study to determine a single dose bioavailablity of PA32540 is similar to EC aspirin 325 mg with respect to salicylic acid.

Platelet Hyperreactivity to Aspirin and Stroke [Recruiting]
STUDY QUESTIONS

- What is the real prevalence of platelet "resistance" to aspirin during the acute phase

of stroke and after 1 year, as measured using different platelet function tests?

- Do all methods measure similar levels of resistance, or are some methods more sensitive

than others?

- Does this resistance result in a worse clinical prognosis? Is this result independent

of other variables?

OBJECTIVES

1. Hospital Phase (Acute Stroke)

- Determination, using various methods, of the prevalence of platelet

hyperreactivity in patients treated with aspirin to treat ischemic stroke (acute phase)

- Comparison of different assessment methods and identification of the most accurate

of these

- Identification of variables that correlate with platelet hyperreactivity

2. Follow-up Phase

- Correlation between platelet hyperreactivity and important clinical outcomes at 12

months

- Correlation between platelet hyperreactivity and death or dependency at hospital

discharge, at 3 months, and at 12 months (Modified Rankin Scale)

- Correlation between platelet hyperreactivity and recurrent stroke of any type

- Correlation between different methods for evaluating platelet functions and

identification of the most accurate method

- Analysis of hyperreactivity over time

THE STUDY

- The study will include 200 consecutive patients seen in the emergency department of a

large, urban hospital (1500 inpatient beds) and diagnosed with stroke in the acute phase; these patients will be treated with aspirin for an undetermined period

- The investigators will not include patients who require full anticoagulation treatment,

regardless of the cause

- Importantly, the analysis of primary and secondary outcomes will be carried out after

blinding the examiner to the results of the platelet aggregation tests

PLATELET TESTS

- Whole Blood Aggregometer, ChronoLog

- VerifyNow, Accumetrics

- PFA-100, Siemens

- Plateletworks, Helena

- Impact-R, Diamed

- Serum thromboxane B2

more trials >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 7 ratings/reviews, Ecotrin has an overall score of 7.43. The effectiveness score is 8 and the side effect score is 8.57. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Ecotrin review by 45 year old male patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   headache
Dosage & duration:   325 mg taken once for the period of 1 day
Other conditions:   nonce
Other drugs taken:   none
  
Reported Results
Benefits:   Pain and pressure in front temporal lobes was reduced 50% within 2 hours of initial treament. Within 4 hours an overall 80% reduction in symptom severity.
Side effects:   No side effects were noticed over a 72 hour period following initial treament taken in the evening.
Comments:   One 325 mg tablet taken with 12 oz glass of water in evening.

 

Ecotrin review by 15 year old male patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   pain
Dosage & duration:   300mg taken once for the period of one week
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   The treatment benefits from taking 300 milligrams of Bayer aspirin for headache pain were decreased pain. The positive effects for diminishing the pain were noticed in about half an hour to a full hour or so. The headache pain was nearly and sometimes even completely relieved with the Bayer. But, after a few hours or so, the pain would come back and I would have to take more of the drug.
Side effects:   No side effects were noticed.
Comments:   The treatment would start as soon as pain was noticed. 300 milligrams of aspirin was taken for every headache episode.

 

Ecotrin review by 69 year old male patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   CAD
Dosage & duration:   75 mg. taken orally, once daily, post cibos. for the period of 2 years
Other conditions:   Hypertension.
Other drugs taken:   Pantoprazol, Metoprolol, Clopidogrel, Amlodipine, Atorvastatin, Ezetimibe, Vitamin-E
  
Reported Results
Benefits:   I am in reasonable good health. I am non-diabetic, Serum Glucose level is normal [Fasting=100, PP=104]. I am a non-smoker since 7th March, 1975 [prior to that I smoked 60 cigarettes a day for17 years].My Blood lipids are within normal limits [Total Cholesterol=108, HDL=36, LDL=62,VLDL=10.HDL is a bit low [36] but TC:HDL ratio=3.00 and appears to be within favourable range of low risk of "up to 4.5". Kidney function is also within normal range. Liver Function is also normal except SGPT=46. Haemogram is normal. Hb%=15.1. Serum Prostate Specific Antigen=0.75, well within nornal range.
Side effects:   I developed severe epigastric pain, relieved by liquid antacids in June 2006. I had to bear with it till Gastroscopy confirmed Duodenal Ulcer and I had to discontinue Aspirin since December 2006. My HDL is 36. SGPT is slightly raised since 2004. I developed severe Hypothyroidism in July 2007 and have to take Thyroxine Sodium since confirmation of the diagnosis. Echocardiography reports Atherosclerotic AV and AO root. USG reports Fatty infiltration of Pancreas and Partially Contracted GB but I have no complain. I am having occasional pain in joints and they are being cured without any additional drug
Comments:   In April 2005, I felt some mild discomfort in my chest or precordium, which was did not simulate any cardiac pain, ECG was within normal limit, even then I was admitted in a Hospital. Trop-T test indicated Myocardial Infarction. Angiography revealed 90% block in Left Posterior Circumflex Artery, PTCA was done followd by non-drug-elluting stent.

See all Ecotrin reviews / ratings >>

Page last updated: 2014-12-05

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