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Econochlor (Chloramphenicol Ophthalmic) - Summary

 

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Bone marrow hypoplasia, including aplastic anemia and death has been reported following local application of chloramphenicol. Chloramphenicol should not be used when less potentially dangerous agents would be expected to provide effective treatment.

 

ECONOCHLOR SUMMARY

Econochlor®
chloramphenicol
Sterile Ophthalmic
Solution and Ointment

ECONOCHLOR® (Chloramphenicol) is a sterile topical ophthalmic antibacterial prepared in solution and ointment forms.

Chloramphenicol should be used only in those serious infections for which less potentially dangerous drugs are ineffective or contraindicated. Bacteriological studies should be performed to determine the causative organisms and their sensitivity to chloramphenicol (See Box Warning). For treatment of ocular infections involving the conjunctiva and/or cornea caused by chloramphenicol-susceptible organisms.

Chloramphenicol has a wide spectrum of antimicrobial activity and is effective against many gram negative and gram positive bacteria, including the following common eye pathogens:

Staphylococcus aureus

Streptococci, including Streptococcus pneumoniae

Escherichia coli

Haemophilus influenzae

Klebsiella/Enterobacter species

Neisseria species

Moraxella lacunata (Morax-Axenfeld bacillus)

The product does not provide adequate coverage against:

Pseudomonas aeruginosa

Serratia marcescens

ECONOCHLOR NEWS HIGHLIGHTS

Published Studies Related to Econochlor (Chloramphenicol Ophthalmic)

Chloramphenicol versus ampicillin plus gentamicin for community acquired very severe pneumonia among children aged 2-59 months in low resource settings: multicentre randomised controlled trial (SPEAR study). [2008.01.12]

Randomised equivalency trial comparing 2.5% povidone-iodine eye drops and ophthalmic chloramphenicol for preventing neonatal conjunctivitis in a trachoma endemic area in southern Mexico. [2007.11]

Open-label randomized trial of oral trimethoprim-sulfamethoxazole, doxycycline, and chloramphenicol compared with trimethoprim-sulfamethoxazole and doxycycline for maintenance therapy of melioidosis. [2005.10]

Ceftriaxone as effective as long-acting chloramphenicol in short-course treatment of meningococcal meningitis during epidemics: a randomised non-inferiority study. [2005.07.23]

Chloramphenicol treatment for acute infective conjunctivitis in children in primary care: a randomised double-blind placebo-controlled trial. [2005.07.02]

more>>

Clinical Trials Related to Econochlor (Chloramphenicol Ophthalmic)

Ceftriaxone Versus Chloramphenicol for Treatment of Severe Pneumonia in Children [Recruiting]

Alcohol 20% for Separation of Pterygium and Comparison of Different Wound Closure Methods [Recruiting]

Long Term Protection by and Persistence of Vi Antibodies Induced by Vi-rEPA Conjugate Vaccines in Vietnamese Children Injected at 2-5 Years or at 5-8 Years of Age [Completed]

A Randomized Double Blinded Comparison of Ceftazidime and Meropenem in Severe Melioidosis [Recruiting]

Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis [Recruiting]

more>>

Page last updated: 2008-03-26

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