ADVERSE REACTIONS
Adverse effects are listed in decreasing order of severity.
Hypersensitivity
Anaphylaxis, rash, urticaria, subacute cutaneous lupus erythematosus-like reactions, photosensitivity.
Cardiovascular
Arrhythmia, postural hypotension.
Metabolic
Diabetes mellitus, hyperkalemia, hypokalemia, hyponatremia, acidosis, hypercalcemia, hyperglycemia, glycosuria, hyperuricemia, hypochloremia.
Gastrointestinal
Jaundice and/or liver enzyme abnormalities, pancreatitis, nausea and vomiting, diarrhea, constipation, abdominal pain.
Renal
Acute renal failure (one case of irreversible renal failure has been reported), interstitial nephritis, renal stones composed primarily of triamterene, elevated BUN, and serum creatinine, abnormal urinary sediment.
Hematologic
Leukopenia, thrombocytopenia and purpura, megaloblastic anemia.
Musculoskeletal
Muscle cramps.
Central Nervous System
Weakness, fatigue, dizziness, headache, dry mouth.
Miscellaneous
Impotence, sialadenitis.
Thiazides alone have been shown to cause the following additional adverse reactions:
Central Nervous System
Paresthesias, vertigo.
Ophthalmic
Xanthopsia, transient blurred vision.
Respiratory
Allergic pneumonitis, pulmonary edema, respiratory distress.
Other
Necrotizing vasculitis, exacerbation of lupus.
Hematologic
Aplastic anemia, agranulocytosis, hemolytic anemia.
Neonate and infancy
Thrombocytopenia and pancreatitis−rarely, in newborns whose mothers have received thiazides during pregnancy.
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