NEWS HIGHLIGHTS
Published Studies Related to Dyazide (Hydrochlorothiazide / Triamterene)
Bioequivalence evaluation of a triamterene-hydrochlorothiazide generic product: a new bioequivalence index for fixed-dose combinations. [2011.02]
In this study, an open, double-blind, randomized, two-period, two-group crossover design was conducted in 14 healthy volunteers to study the bioequivalence of a fixed-dose generic product. After administration of test or reference products to each volunteer, both active ingredients were determined simultaneously in plasma samples using a developed and validated HPLC-UV method, and pharmacokinetic parameters, including C(max), T(max), AUC(0-t) , AUC(0infinity), terminal elimination rate constant (lambdaz), volume of distribution in steady state (Vd(ss)), mean residence time (MRT), clearance (Cl), terminal elimination rate constant (Kel) were determined in each subject using the standard non-compartmental approach...
Effect of quinapril and triamterene/hydrochlorothiazide on cardiac and vascular end-organ damage in isolated systolic hypertension. [1998.02]
We compared, in a prospective double-blind randomized study, the effect of the angiotensin-converting enzyme inhibitor quinapril (QUI) with that of triamterene/hydrochlorothiazide (THCT) treatment on cardiovascular end-organ damage in subjects with untreated isolated systolic hypertension (ISH)... Results of LV diastolic function and peripheral vascular resistance were less clear but appear to show less favorable changes in the THCT subjects treatment group.
Pharmacokinetics and pharmacodynamics of triamterene and hydrochlorothiazide and their combination in healthy volunteers. [1997.10]
Although triamterene has been in clinical use for over 30 years, the linearity of triamterene kinetics was not systematically tested. Moreover, although triamterene is mostly applied concomitantly with thiazide-type diuretics the interaction of triamterene (TA) with hydrochlorothiazide (HCT) is subject to a controversial discussion.
Felodipine or hydrochlorothiazide/triamterene for treatment of hypertension in the elderly: effects on blood pressure, hypertensive heart disease, metabolic and hormonal parameters. [1996.05]
The aim of the study was to compare the antihypertensive efficacy of either felodipine or the diuretic combination hydrochlorothiazide/triamterene in a group (n = 65) of elderly (> or = 70 years) hypertensives (office blood pressure > or = 160/95 mmHg) with special regard to ambulatory blood pressure monitoring, hypertensive heart disease and metabolic parameters...
A study of plasma sodium levels in elderly people taking amiloride or triamterene in combination with hydrochlorothiazide. [1993.10]
This study was performed to compare the effect of one month's treatment with hydrochlorothiazide (25 mg) in combination with either amiloride (2.5 mg) or triamterene (50 mg) on plasma sodium levels in elderly people in institutional care. Fifty residents of NHS nursing or social service residential care established on diuretics for congestive cardiac failure and aged 64 years or over were recruited...
Clinical Trials Related to Dyazide (Hydrochlorothiazide / Triamterene)
Efficacy of Irbesartan/Hydrochlorothiazide Versus Valsartan/Hydrochlorothiazide in Mild to Moderate Hypertension [Recruiting]
The primary objective is to compare the efficacy of irbesartan/hydrochlorothiazide 300/25mg
against valsartan/hydrochlorothiazide 160/25mg in reducing mean systolic blood pressure (SBP)
as measured by home blood pressure monitoring (HBPM) after 24 weeks compared with baseline.
The secondary objectives are:
- To compare the percentage of patients with normal blood pressure as measured by HBPM and
at the doctor's office at weeks 16 and 24
- To compare the differences in mean Diastolic Blood Pressure (DBP), mean morning and
evening SBP and DBP evaluated by HBPM at weeks 16 and 24
- To compare the difference in mean SBP evaluated by HBPM at week 16
- To compare the differences in mean SBP and DBP evaluated at the doctor's office at weeks
16 and 24
- To determine the incidence and severity of adverse events
Irbesartan/Hydrochlorothiazide and Irbesartan in the Treatment of Mild to Moderate Hypertension [Completed]
Study Objectives :
- To demonstrate the reduction in office Blood Pressure following a 8-week regimen of
irbesartan / hydrochlorothiazide using irbesartan as a reference.
- To demonstrate the reduction in office Blood Pressure after 4-week regimen of irbesartan
/ hydrochlorothiazide using irbesartan as a reference.
- To compare the response rate (defined as office Systolic Blood Pressure/Diastolic Blood
Pressure reduce more than 10mmHg from Week 0) of patients after 4-week and 8-week
regimen of irbesartan / hydrochlorothiazide versus irbesartan.
- To compare the proportion of patients requiring titration after 4-week regimen of
irbesartan/hydrochlorothiazide versus irbesartan
- To ascertain the safety and tolerability of irbesartan / hydrochlorothiazide versus
irbesartan when administered once daily
A Randomized, Double-Blind, Placebo-Controlled, Forced-Titration, Phase IV Study Comparing Telmisartan 80 mg + Hydrochlorothiazide 25 mg [Micardis HCT] Versus Valsartan 160 mg + Hydrochlorothiazide 25 mg [Diovan HCT] Taken Orally for Eight Weeks in Patients With Stage 1 and Stage 2 Hypertension. [Completed]
A Comparison of Telmisartan + Hydrochlorothiazide With Amlodipine + Hydrochlorothiazide in the Control of Blood Pressure in Older Patients With Predominantly Systolic Hypertension. (ATHOS Study) [Completed]
The primary objective of this clinical trial was to show that the combination of telmisartan
80 mg + hydrochlorothiazide (HCTZ) 12. 5 mg was not inferior to and was possibly superior to
amlodipine 10 mg + HCTZ 12. 5 mg in reducing the systolic blood pressure (SBP) in the last six
hours of the 24-hour dose period [as measured by 24-hour ambulatory blood pressure monitoring
( ABPM)] in elderly patients with predominantly systolic hypertension. The primary endpoint
was the change from baseline in SBP in the last six hours of the 24-hour dose period (as
measured by 24-hour ABPM) at the end-of-study visit.
Efficacy and Safety of Valsartan, Hydrochlorothiazide and Amlodipine Combination Therapy in Hypertension [Completed]
This study is designed to evaluate the efficacy and safety of the combination valsartan with
hydrochlorothiazide and amlodipine in hypertensive patients previously treated with valsartan
with hydrochlorothiazide and remaining uncontrolled. A naturalistic approach will be taken
comparing two different possible ways to achieve the higher dosage of the triple combination,
i. e. 160 mg of valsartan and 25 mg of hydrochlorothiazide with amlodipine 10 mg.
Reports of Suspected Dyazide (Hydrochlorothiazide / Triamterene) Side Effects
Drug Ineffective (3),
Urinary Tract Infection (3),
Anaphylactic Reaction (2),
Urticaria (2),
Cerebrovascular Disorder (2),
Generalised Oedema (2),
Vaginal Haemorrhage (2),
Speech Disorder (2),
Palpitations (2),
Oedema Peripheral (2), more >>
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