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Dutoprol (Metoprolol Succinate / Hydrochlorothiazide) - Summary

 
 



BOX WARNING

Ischemic Heart Disease: Following abrupt cessation of therapy with certain beta-blocking agents, exacerbations of angina pectoris and, in some cases, myocardial infarction have occurred. When discontinuing chronically administered DUTOPROL, particularly in patients with ischemic heart disease, the dosage should be gradually reduced over a period of 1–2 weeks and the patient should be carefully monitored. If angina markedly worsens or acute coronary insufficiency develops, DUTOPROL or beta-blocking agent administration should be reinstated promptly, at least temporarily, and other measures appropriate for the management of unstable angina should be taken. Patients should be warned against interruption or discontinuation of therapy without the physician’s advice. Because coronary artery disease is common and may be unrecognized, it may be prudent not to discontinue DUTOPROL therapy abruptly even in patients treated only for hypertension.

 

DUTOPROL SUMMARY

DUTOPROL™
(metoprolol succinate extended release/hydrochlorothiazide)
Tablet, Film Coated

DUTOPROL™ (metoprolol succinate extended release/hydrochlorothiazide) combines a beta1-selective (cardioselective) adrenoceptor blocking agent and a diuretic, hydrochlorothiazide.

DUTOPROL is indicated for the management of hypertension. The fixed-dose combination is not indicated for initial therapy (see DOSAGE AND ADMINISTRATION).


See all Dutoprol indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Dutoprol (Metoprolol / Hydrochlorothiazide)

Renovascular Hypertension Caused by Compressive Adenopathy
Source: Medscape Critical Care Headlines [2016.08.19]
Was this 28-year-old patient's abdominal mass related to his encephalopathic symptoms and new-onset hypertension?
Applied Radiology

Study suggests ways to block hypertension in those with sleep apnea
Source: Hypertension News From Medical News Today [2016.08.17]
Obstructive sleep apnea - a disorder that affects nearly one out of four people between the ages of 30 and 70 - is a common cause of high blood pressure. In the Aug.

Hypertension prevalence higher in lower-income countries for the first time
Source: Hypertension News From Medical News Today [2016.08.09]
New research indicates that the prevalence of high blood pressure in low- and middle-income countries has overtaken that of high-income countries.

To beat hypertension, take the 'clinic' to the people
Source: Hypertension News From Medical News Today [2016.08.08]
Study aims to eliminate racial differences in outcomes of blood pressure control programs.

Can drugs that treat hypertension also treat depression?
Source: Depression News From Medical News Today [2016.08.01]
In the current issue of Psychotherapy and Psychosomatics, the relationship of drugs that are generally used for treating hypertension (angiotensin converting enzyme inhibitors) are examined in...

more news >>

Published Studies Related to Dutoprol (Metoprolol / Hydrochlorothiazide)

Factorial antihypertensive study of an extended-release metoprolol and hydrochlorothiazide combination. [2006.12]
BACKGROUND: To attain goal blood pressure (BP), many hypertensive patients require combination antihypertensive therapy. Thiazide diuretic/beta-blocker regimens lower BP, and clinical studies indicate that they reduce the risk for cardiovascular consequences of hypertension. Fixed-dose combination tablets can simplify multidrug treatment regimens... CONCLUSIONS: Extended-release metoprolol/hydrochlorothiazide is an effective antihypertensive combination that offers additive antihypertensive contributions from both components.

Blood pressure and aortic elastic properties--verapamil SR/trandolapril compared to a metoprolol/hydrochlorothiazide combination therapy. [1998.08]
The effects of 2 fixed antihypertensive combination drugs on blood pressure and aortic elastic properties were compared in 2 parallel groups. Twenty-six patients for 6 months received a calcium antagonist plus ACE inhibitor (verapamil SR 180 mg/trandolapril 1 mg (Vera/Tran)) and 25 patients a beta-adrenoceptor antagonist plus diuretic (metoprolol 100 mg/hydrochlorothiazide 12.5 mg (Meto/HCTZ))...

more studies >>

Clinical Trials Related to Dutoprol (Metoprolol / Hydrochlorothiazide)

Food Study of Metoprolol Tartrate/Hydrochlorothiazide Tablets 100/50 mg to Lopressor HCT® Tablets 100/50 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan metoprolol tartrate/hydrochlorothiazide 100/50 mg tablets to Novartis Lopressor HCT® 100/50 mg tablets following a single, oral 100/50 mg (1 x 100/50 mg) dose administration under fed conditions.

Fasting Study of Metoprolol Tartrate/Hydrochlorothiazide Tablets 100/50 mg and Lopressor HCT® Tablets 100/50 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan metoprolol tartrate/hydrochlorothiazide 100/50 mg tablets to Novartis Lopressor HCT® 100/50 mg tablets following a single, oral 100/50 mg (1 x 100/50 mg) dose administration under fasting conditions.

Action to Control Cardiovascular Risk in Diabetes (ACCORD) [Completed]
The purpose of this study is to prevent major cardiovascular events (heart attack, stroke, or cardiovascular death) in adults with type 2 diabetes mellitus using intensive glycemic control, intensive blood pressure control, and multiple lipid management.

more trials >>


Page last updated: 2016-08-19

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