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Dutoprol (Metoprolol Succinate / Hydrochlorothiazide) - Summary

 
 



BOX WARNING

Ischemic Heart Disease: Following abrupt cessation of therapy with certain beta-blocking agents, exacerbations of angina pectoris and, in some cases, myocardial infarction have occurred. When discontinuing chronically administered DUTOPROL, particularly in patients with ischemic heart disease, the dosage should be gradually reduced over a period of 1–2 weeks and the patient should be carefully monitored. If angina markedly worsens or acute coronary insufficiency develops, DUTOPROL or beta-blocking agent administration should be reinstated promptly, at least temporarily, and other measures appropriate for the management of unstable angina should be taken. Patients should be warned against interruption or discontinuation of therapy without the physician’s advice. Because coronary artery disease is common and may be unrecognized, it may be prudent not to discontinue DUTOPROL therapy abruptly even in patients treated only for hypertension.

 

DUTOPROL SUMMARY

DUTOPROL™
(metoprolol succinate extended release/hydrochlorothiazide)
Tablet, Film Coated

DUTOPROL™ (metoprolol succinate extended release/hydrochlorothiazide) combines a beta1-selective (cardioselective) adrenoceptor blocking agent and a diuretic, hydrochlorothiazide.

DUTOPROL is indicated for the management of hypertension. The fixed-dose combination is not indicated for initial therapy (see DOSAGE AND ADMINISTRATION).


See all Dutoprol indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Dutoprol (Metoprolol / Hydrochlorothiazide)

Increased stroke risk associated with low education, smoking and hypertension
Source: Hypertension News From Medical News Today [2014.08.19]
Adults smokers with limited education face a greater risk of stroke than those with a higher education, according to new research in the American Heart Association's journal Stroke.

The risk of resistant hypertension increases with the severity of sleep apnea
Source: Hypertension News From Medical News Today [2014.08.19]
A new study shows a strong association between severe, untreated obstructive sleep apnea and the risk of elevated blood pressure despite the use of high blood pressure medications.

Resistant hypertension: a review for physicians
Source: Hypertension News From Medical News Today [2014.08.18]
A new review article on resistant hypertension, which affects about 1 in 10 people with high blood pressure, is aimed at helping physicians assess and manage patients with the condition.

CDC study shows higher rates of hypertension among adults with disabilities
Source: Cardiovascular / Cardiology News From Medical News Today [2014.08.15]
CDC researchers report that adults with disabilities had higher rates of hypertension compared to adults without disabilities.

Study examines midlife hypertension and cognitive change over 20-year period
Source: Hypertension News From Medical News Today [2014.08.05]
Hypertension in middle age (48 to 67 years) was associated with a greater, although still a modest, decline in cognition over a 20-year period compared with individuals who had normal blood...

more news >>

Published Studies Related to Dutoprol (Metoprolol / Hydrochlorothiazide)

Factorial antihypertensive study of an extended-release metoprolol and hydrochlorothiazide combination. [2006.12]
BACKGROUND: To attain goal blood pressure (BP), many hypertensive patients require combination antihypertensive therapy. Thiazide diuretic/beta-blocker regimens lower BP, and clinical studies indicate that they reduce the risk for cardiovascular consequences of hypertension. Fixed-dose combination tablets can simplify multidrug treatment regimens... CONCLUSIONS: Extended-release metoprolol/hydrochlorothiazide is an effective antihypertensive combination that offers additive antihypertensive contributions from both components.

Blood pressure and aortic elastic properties--verapamil SR/trandolapril compared to a metoprolol/hydrochlorothiazide combination therapy. [1998.08]
The effects of 2 fixed antihypertensive combination drugs on blood pressure and aortic elastic properties were compared in 2 parallel groups. Twenty-six patients for 6 months received a calcium antagonist plus ACE inhibitor (verapamil SR 180 mg/trandolapril 1 mg (Vera/Tran)) and 25 patients a beta-adrenoceptor antagonist plus diuretic (metoprolol 100 mg/hydrochlorothiazide 12.5 mg (Meto/HCTZ))...

more studies >>


Page last updated: 2014-08-19

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